Results 81 to 90 of about 2,323,002 (379)
FEBS Letters, EarlyView.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
Transcription factors - Methods and protocols
European Journal of Histochemistry, 2011 A hearty wellcome to prof. Higgins editorial toil: a necessary tool for those colleagues (young and older) fighting each day with the transcription factor they are involved with.
CarloAlberto Redi
doaj +1 more source
Transcription factors in megakaryocytes and platelets
Frontiers in Immunology, 2023 Transcription factors bind promoter or regulatory sequences of a gene to regulate its rate of transcription. However, they are also detected in anucleated platelets.
Hengjie Yuan +7 more
doaj +1 more source
Genome-wide discovery of modulators of transcriptional interactions in human B lymphocytes [PDF]
RECOMB'06 Proceedings, LNCS 3909, Springer, 2006, 2005 Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription factor and its target(s). These include, among others, transcription factor activation by phosphorylation and acetylation, formation of active complexes with one or more co-factors, and ...
arxiv +1 more source
Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos. [PDF]
, 2018 The regulation of transcription requires the coordination of numerous activities on DNA, yet how transcription factors mediate these activities remains poorly understood.
Darzacq, Xavier +6 more
core +1 more source
Most transcription factor binding sites are in a few mosaic classes of the human genome [PDF]
, 2010 Background: Many algorithms for finding transcription factor binding sites have concentrated on the characterisation of the binding site itself: and these algorithms lead to a large number of false positive sites. The DNA sequence which does not bind has
Evans, Kenneth J.
core +3 more sources
FEBS Letters, EarlyView.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
Patterns of subnet usage reveal distinct scales of regulation in the transcriptional regulatory network of Escherichia coli [PDF]
, 2010 The set of regulatory interactions between genes, mediated by transcription factors, forms a species' transcriptional regulatory network (TRN). By comparing this network with measured gene expression data one can identify functional properties of the TRN and gain general insight into transcriptional control.
arxiv +1 more source
The lower bound on the precision of transcriptional regulation [PDF]
Phys. Rev. E 90 (2014) 032708, 2014 The diffusive arrival of transcription factors at the promoter sites on the DNA sets a lower bound on how accurately a cell can regulate its protein levels. Using results from the literature on diffusion-influenced reactions, we derive an analytical expression for the lower bound on the precision of transcriptional regulation.
arxiv +1 more source
Walking, hopping and jumping: a model of transcription factor dynamics on DNA [PDF]
, 2011 We present a model of how transcription factors scan DNA to find their specific binding sites. Following the classical work of Winter et al. (1981), our model assumes two modes of transcription factor dynamics.
Barnes, David J., Chu, Dominique
core