Results 21 to 30 of about 2,065,027 (229)
Structure and function of negative feedback loops at the interface of genetic and metabolic networks [PDF]
, 2006 The molecular network in an organism consists of transcription/translation regulation, protein-protein interactions/modifications and a metabolic network, together forming a system that allows the cell to respond sensibly to the multiple signal molecules
Andersson, Anna M. C. +3 more
core +4 more sources
Modeling transcriptional regulation [PDF]
Nature Genetics, 2014 Systems models of the ways transcription factor networks operate and evolve are essential for understanding cell identity, developmental commitment and regulatory variation. Terminologies from different techniques and disciplines may need to be adapted or put aside to make and test these models effectively.
openaire +2 more sources
Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]
, 2015 Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C +2 more
core +1 more source
Microbiology Spectrum, 2023 Transcription factors (TFs) play a crucial role in regulating gene expression in living organisms, and any malfunction in their functions can lead to severe physiological consequences.
Longguang Qin +5 more
doaj +1 more source
Regulation of transcription elongation in response to osmostress [PDF]
, 1967 Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell fitness when yeast cells are exposed
Begley, Victoria Sarah +7 more
core +3 more sources
Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers. [PDF]
, 2018 In Metazoans, transcription of most genes is driven by the use of multiple alternative promoters. Although the precise regulation of alternative promoters is important for proper gene expression, the mechanisms that mediates their differential ...
Bardales, Jorge A +4 more
core +3 more sources
ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes [PDF]
, 2007 ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets.
A. A. Ferrando +27 more
core +3 more sources
Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]
, 1998 Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E. +6 more
core +1 more source
Towards molecular systems biology of gene transcription and regulation [PDF]
, 2010 Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, Patrick
core +1 more source
Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background Salmonella belongs to the Enterobacteriaceae family, a gram-negative, non-spore-forming, rod-shaped, motile, and pathogenic bacteria that transmit through unhygienic conditions.
Malaisamy Arunkumar +7 more
doaj +1 more source