Results 201 to 210 of about 5,966,093 (336)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional Activation of the <i>TREM2</i> Gene by ZEB2 in a Zinc Finger-Dependent Manner. [PDF]

Genes (Basel)
Yanaizu M, Takata Y, Kato M, Fujiwara H, Kino Y.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

IRF6 induces endothelial dysfunction through the transcriptional activation of NDRG1 and aggravates low shear stress-mediated atherosclerosis. [PDF]

iScience
Chen Y, Zhang Y, Rui S, Dong B, Xu X, Jin Y.   +5 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

LncRNA MCF2L-AS1 promotes malignant progression of colorectal cancer by post-transcriptional activation of MCF2L. [PDF]

Discov Oncol
Shi H, Qiu L, Tan P.
europepmc   +1 more source

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs.

Cell, 1995
A. Minden, A. Lin, François Xavier Claret, A. Abo, M. Karin   +4 more
semanticscholar   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems. [PDF]

Nat Commun
Liang Z, Maddineni A, Ortega JA, Magdongon CB, Jambardi S, Roy S, Tycko J, Patil A, Manzano M, Bartom ET, Gottwein E.   +10 more
europepmc   +1 more source

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Molecular and Cellular Biology, 1996
Jo A. Forsythe, B. Jiang, N. Iyer, F. Agani, S. Leung, R. Koos, G. Semenza   +6 more
semanticscholar   +1 more source