Results 161 to 170 of about 2,976,192 (192)

Transcriptional silencing of homeotic genes in drosophila

BioEssays, 1995
AbstractHomeotic genes are subject to transcriptional silencing, which prevents their expression in inappropriate body regions. Here, we shall focus on Drosophila, as little is known about this process in other organisms. Evidence is accumulating that silencing of Drosophila homeotic genes is conferred by two types of cis‐regulatory sequences ...
M, Bienz, J, Müller
openaire   +2 more sources

Spreading of post‐transcriptional gene silencing along the target gene promotes systemic silencing

The Plant Journal, 2004
SummaryTransitive silencing and grafting‐induced gene silencing phenomena were combined to investigate whether a primary target β‐glucuronidase (gus) gene could promote the generation of systemic transitive silencing signals. Tobacco plants with hemizygous or homozygous silencer locus and in trans silenced primary target were used as a source of post ...
Rubén Darío, García-Pérez, Helena Van, Houdt, Anna, Depicker   +2 more
openaire   +2 more sources

Transcriptional Silencer in Intron I of the Rat Renin Gene

Regulatory Peptides, 1994
In the present study we investigated the influence of intron I of the rat renin gene on the transcriptional activity of its promoter in cell culture. The presence of intron I abolished the transcription of reporter genes (luciferase and lacZ) in the non-renin-expressing human embryonic kidney cell line 293, while it did not significantly affect the ...
T, Voigtländer, A, Ripperger, D, Ganten, M, Bader   +3 more
openaire   +2 more sources

Transcriptional Gene Silencing Using Small RNAs

2009
RNA interference is a potent gene silencing pathway initiated by short molecules of double-stranded RNA. Small interfering RNAs (siRNAs) with full sequence complementarity to mRNAs induce cleavage of their target transcripts in the cytoplasm. Recent evidence has shown, however, that siRNAs can also function in the nucleus of mammalian cells to affect ...
Daniel H, Kim, John J, Rossi
openaire   +2 more sources

Post-transcriptional gene silencing: conservation and sequences

Trends in Plant Science, 2000
Gene expression is controlled by a variety of mechanisms. Post-transcriptional gene silencing (PTGS) is one mechanism that degrades specific messenger RNAs and thereby reduces the expression of a specific gene. PTGS has many names: cosuppression in plants, quelling in fungi and RNA interference in animals, but in all cases, degraded mRNA decreases gene
openaire   +2 more sources

Genetic analysis of RNA-mediated transcriptional gene silencing

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2004
The 'nuclear side' of RNA interference (RNAi) is increasingly recognized as an integral part of RNA-mediated gene silencing networks. Current data are consistent with the idea that epigenetic changes, such as DNA (cytosine-5) methylation and histone modifications, can be targeted to identical DNA sequences by short RNAs derived via Dicer cleavage of ...
Marjori, Matzke, Werner, Aufsatz, Tatsuo, Kanno, Lucia, Daxinger, Istvan, Papp, M Florian, Mette, Antonius J M, Matzke   +6 more
openaire   +2 more sources

Low-level illegitimate transcription of genes may be to silence the genes

Biochemical and Biophysical Research Communications, 2005
In yeast and plants, low level transcription of a gene is recently revealed to be required to repress the gene. It may account for the widely low level illegitimate transcriptions of tissue-specific genes reported in mammalian cells. This hypothetical link gives insight into both analysis of transcription-associated evolutionary events and further ...
openaire   +2 more sources

RNA-Mediated Transcriptional Gene Silencing in Human Cells

2008
The utilization of small interfering RNAs (siRNAs) represents a new paradigm in gene knockout technology. siRNAs can be used to knockdown the expression of a particular gene by targeting the mRNA in a post-transcriptional manner. While there are a plethora of reports applying siRNA-mediated post-transcriptional silencing (PTGS) therapeutically there ...
openaire   +2 more sources

Temperature modulates virus‐induced transcriptional gene silencing via secondary small RNAs

New Phytologist, 2021
Attila Molnár, Douglas Pyott, Yue Fei   +2 more
exaly  

Grapevine red blotch virus C2 and V2 are suppressors of post-transcriptional gene silencing

Heliyon, 2023
Sunitha Sukumaran
exaly