Results 231 to 240 of about 3,175,496 (289)

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

A TERRA-NONO axis drives fibroblast reprogramming in cancer. [PDF]

Sci Adv
Di Cicco E, Isma J, Sol S, Restivo G, Mazzeo L, Katarkar A, Goruppi S, White JR, Hafner J, Neel VA, Mandinova A, Levesque MP, Dotto GP.   +12 more
europepmc   +1 more source

<i>HOTAIR</i> Promotes Prostate Cancer Progression by facilitating CDK9-Pol II Association and Transcriptional Elongation. [PDF]

Int J Biol Sci
Qian Y, Wang B, Su G, Li P, Zhao Z, Jiang Y, Zhang L, Zhao Z, Li MJ, Shi J, Huang D, Lu W.   +11 more
europepmc   +1 more source

Decoding chromatin-associated RNA (caRNA) interaction networks: from genome-wide dynamic capture to epigenetic mechanisms in plants and animals. [PDF]

Epigenetics
Liu C, Li W, Lv Q, Su R.
europepmc   +1 more source

Metabolic-epigenetic regulation of the HBV cccDNA reservoir: pathways underpinning viral persistence. [PDF]

Front Microbiol
Peng Q, Hao L, Li S, Yu F, Li N, Ye F, Hu X.   +6 more
europepmc   +1 more source