Results 251 to 260 of about 357,564 (302)

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

<i>CtARF4</i> Regulates Inflorescence Development Through Transcriptional Regulation of <i>CtMADS24</i> in Safflower. [PDF]

Plants (Basel)
Ge H, Xue P, Liu Y, Pu X, Zhu W, Luan S, Yang Q, Dong Y.   +7 more
europepmc   +1 more source

Crosstalk Between <i>Cis</i>-Regulatory Elements and Metabolism Reprogramming in Hepatocellular Carcinoma. [PDF]

Cancers (Basel)
Ren Y, Tang D, Ding X, He M.
europepmc   +1 more source

Genome-wide identification and characterization of argonaute, dicer-like, and RNA-dependent RNA polymerase gene families in potato (Solanum tuberosum): Advancing RNA interference-based crop enhancement. [PDF]

PLoS One
Shuvo MNH, Hassan M, Musa MA, Hossain R, Konak JN, Akond Z, Ahmed FF.   +6 more
europepmc   +1 more source

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Post-transcriptional gene silencing by double-stranded RNA

Nature Reviews Genetics, 2001
Imagine being able to knock out your favourite gene with only a day's work. Not just in one model system, but in virtually any organism: plants, flies, mice or cultured cells. This sort of experimental dream might one day become reality as we learn to harness the power of RNA interference, the process by which double-stranded RNA induces the silencing ...
Amy A Caudy
exaly   +3 more sources

Transcriptional gene silencing mutants

Plant Molecular Biology, 2000
Genetic approaches to identify molecular components of transcriptional gene silencing (TGS) in plants have yielded several Arabidopsis thaliana mutants and identified the first genes involved. All mutations found affect the maintenance of silencing and reactivate silent genes in trans.
Mittelsten Scheid, O., Paszkowski, Jerzy
openaire   +3 more sources

Post-transcriptional gene silencing mutants

Plant Molecular Biology, 2000
It has been known for more than a decade that increasing the gene copy number does not necessarily lead to increased gene activity. Plants have developed efficient mechanisms such as post-transcriptional gene silencing (PTGS) to regulate abnormal gene expression in a sequence-specific fashion.
Morel, J.B., Vaucheret, Herve
openaire   +3 more sources

Transcriptional gene silencing in plants

Russian Journal of Genetics, 2010
The review presents current data on molecular genetic mechanisms of suppression of the gene (transgene) expression in plants at the transcriptional level. The stages of RNA-directed DNA methylation are discussed in detail. Mutations affecting transcriptional gene inactivation without altering nucleotide sequence methylation are described.
T V, Marenkova, E V, Deĭneko
openaire   +2 more sources

Post-transcriptional gene silencing in plants

Current Opinion in Cell Biology, 1997
Overexpression of chimeric transgenes in plants can trigger post-transcriptional gene silencing that is dependent on epigenetic information and physiological conditions. The current view is that unproductive RNA serves as a crucial signal for gene silencing, although direct evidence is lacking for this theory.
A, Depicker, M V, Montagu
openaire   +2 more sources

Post-transcriptional gene silencing across kingdoms

Current Opinion in Genetics & Development, 2000
Post-transcriptional gene silencing (PTGS) as a consequence of the introduction of either transgenes or double-stranded RNA molecules has been found to occur in a number of species. In the past year, studies in different systems have greatly enhanced our understanding of the molecular mechanisms of these phenomena.
COGONI, Carlo, MACINO, Giuseppe
openaire   +3 more sources