Results 301 to 310 of about 1,124,626 (332)
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Post-transcriptional gene silencing across kingdoms
Current Opinion in Genetics & Development, 2000Post-transcriptional gene silencing (PTGS) as a consequence of the introduction of either transgenes or double-stranded RNA molecules has been found to occur in a number of species. In the past year, studies in different systems have greatly enhanced our understanding of the molecular mechanisms of these phenomena.
COGONI, Carlo, MACINO, Giuseppe
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RNA-directed transcriptional gene silencing in mammals
Trends in Genetics, 2005RNA interference is a highly conserved pathway mediating sequence-specific RNA degradation. In plants, the short RNA intermediates of this pathway can also drive transcriptional silencing of target genes by DNA methylation. Until recently, there was no evidence that a similar pathway operated in mammals; two new studies suggest that small RNAs can ...
Elizabeth H, Bayne, Robin C, Allshire
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Transcriptional silencing of homeotic genes in drosophila
BioEssays, 1995AbstractHomeotic genes are subject to transcriptional silencing, which prevents their expression in inappropriate body regions. Here, we shall focus on Drosophila, as little is known about this process in other organisms. Evidence is accumulating that silencing of Drosophila homeotic genes is conferred by two types of cis‐regulatory sequences ...
M, Bienz, J, Müller
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Post-transcriptional gene silencing by siRNAs and miRNAs
Current Opinion in Structural Biology, 2005Recent years have seen a rapid increase in our understanding of how double-stranded RNA (dsRNA) and 21- to 25-nucleotide small RNAs, microRNAs (miRNAs) and small interfering RNAs (siRNAs), control gene expression in eukaryotes. This RNA-mediated regulation generally results in sequence-specific inhibition of gene expression; this can occur at levels as
Filipowicz W +3 more
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The Art of Transcriptional Gene Silencing
Science's STKE, 2006RNA interference (RNAi) targets sequences to be silenced through complementary small interfering (si)RNAs. SiRNAs are bound by Ago proteins, some of which can "slice" and inactivate target RNAs. RNAi silences gene expression at both the posttranscriptional and transcriptional levels.
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Spreading of post‐transcriptional gene silencing along the target gene promotes systemic silencing
The Plant Journal, 2004SummaryTransitive silencing and grafting‐induced gene silencing phenomena were combined to investigate whether a primary target β‐glucuronidase (gus) gene could promote the generation of systemic transitive silencing signals. Tobacco plants with hemizygous or homozygous silencer locus and in trans silenced primary target were used as a source of post ...
Rubén Darío, García-Pérez +2 more
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Transcriptional Silencer in Intron I of the Rat Renin Gene
Regulatory Peptides, 1994In the present study we investigated the influence of intron I of the rat renin gene on the transcriptional activity of its promoter in cell culture. The presence of intron I abolished the transcription of reporter genes (luciferase and lacZ) in the non-renin-expressing human embryonic kidney cell line 293, while it did not significantly affect the ...
T, Voigtländer +3 more
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Transcriptional Gene Silencing Using Small RNAs
2009RNA interference is a potent gene silencing pathway initiated by short molecules of double-stranded RNA. Small interfering RNAs (siRNAs) with full sequence complementarity to mRNAs induce cleavage of their target transcripts in the cytoplasm. Recent evidence has shown, however, that siRNAs can also function in the nucleus of mammalian cells to affect ...
Daniel H, Kim, John J, Rossi
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Post-transcriptional gene silencing: conservation and sequences
Trends in Plant Science, 2000Gene expression is controlled by a variety of mechanisms. Post-transcriptional gene silencing (PTGS) is one mechanism that degrades specific messenger RNAs and thereby reduces the expression of a specific gene. PTGS has many names: cosuppression in plants, quelling in fungi and RNA interference in animals, but in all cases, degraded mRNA decreases gene
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Post-transcriptional gene silencing: Basic concepts and applications
Journal of Biosciences, 2020Mohd Ashraf Ashfaq +7 more
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