Results 281 to 290 of about 1,124,626 (332)

RNA-protein complexes as key regulators of plant secondary metabolism: Biophysical interactions and functional significance. [PDF]

Biochem Biophys Rep
Ugwu OP, Ugwu MN, Onohuean H, Rather HA, Usman IM.   +4 more
europepmc   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

The Transcription Factors HbWRKY29 and HbPTI5 cooperatively enhance rubber tree resistance to powdery mildew. [PDF]

Mol Plant Pathol
Lu Y, Liu Q, Xia L, Peng S, Wang M, Liang X, Zhang Y.   +6 more
europepmc   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

The DNA Demethylase TET1 is a Pivotal Regulator of the miR-124/ISX9-Instructed Conversion of Astrocytes to Induced Neurons. [PDF]

Mol Neurobiol
Papadimitriou E, Iohan LD, Frazeskou A, Xingi E, Costa MR, Thomaidou D.   +5 more
europepmc   +1 more source

SF3B4 stabilizes SREBF1 via 3'UTR binding to drive hepatocellular carcinoma progression. [PDF]

Front Oncol
Fang Y, Wang D, Han L, Li M, He Q, Xu W, Li H, Zeng Z, Lin J, Huang H.   +9 more
europepmc   +1 more source

Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling. [PDF]

Elife
Biswas K, Moore C, Rogers H, Wani KA, Mushtaq A, Pukkila-Worley R, Higgins DP, Walker AK, Mullen GP, Rand JB, Francis MM.   +10 more
europepmc   +1 more source

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Post-transcriptional gene silencing in plants

Current Opinion in Cell Biology, 1997
Overexpression of chimeric transgenes in plants can trigger post-transcriptional gene silencing that is dependent on epigenetic information and physiological conditions. The current view is that unproductive RNA serves as a crucial signal for gene silencing, although direct evidence is lacking for this theory.
Ann Depicker, Marc Van Montagu
exaly   +3 more sources

Transcriptional gene silencing mutants

Plant Molecular Biology, 2000
Genetic approaches to identify molecular components of transcriptional gene silencing (TGS) in plants have yielded several Arabidopsis thaliana mutants and identified the first genes involved. All mutations found affect the maintenance of silencing and reactivate silent genes in trans.
Mittelsten Scheid, O., Paszkowski, Jerzy
openaire   +5 more sources

Post-transcriptional gene silencing in plants by RNA

Plant Cell Reports, 2003
RNA silencing, which is termed post-transcriptional gene silencing in plants, is an RNA degradation process through sequence-specific nucleotide interactions induced by double-stranded RNA. In plants, RNA silencing not only serves as a component of the defense mechanism, but also participates in the regulation of endogenous gene expression in a variety
Prakash P Kumar
exaly   +3 more sources