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Post-transcriptional gene silencing: conservation and sequences
Trends in Plant Science, 2000Gene expression is controlled by a variety of mechanisms. Post-transcriptional gene silencing (PTGS) is one mechanism that degrades specific messenger RNAs and thereby reduces the expression of a specific gene. PTGS has many names: cosuppression in plants, quelling in fungi and RNA interference in animals, but in all cases, degraded mRNA decreases gene
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Long-Term Transcriptional Gene Silencing by RNA Viruses
Trends in Biochemical Sciences, 2018Long-term transcriptional gene silencing has been hampered by delivery issues. A potential solution is the application of RNA viruses that generate small RNAs without any DNA intermediate. Long-term therapy for various diseases is expected after a single administration.
Juozas, Baltusnikas +2 more
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The Art of Transcriptional Gene Silencing
Science, 2006RNA interference (RNAi) targets sequences to be silenced through complementary small interfering (si)RNAs. SiRNAs are bound by Ago proteins, some of which can "slice" and inactivate target RNAs. RNAi silences gene expression at both the posttranscriptional and transcriptional levels.
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2022
Loss-of-function analyses are essential to dissect the complex nature of biological processes, including gametogenesis. Virus-induced gene silencing (VIGS) has been widely used in crop species as an amenable and rapid way to generate gene knockdowns. As a transient assay, VIGS circumvents the generation of stable transgenic lines through laborious and ...
Wang, Zhengming +3 more
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Loss-of-function analyses are essential to dissect the complex nature of biological processes, including gametogenesis. Virus-induced gene silencing (VIGS) has been widely used in crop species as an amenable and rapid way to generate gene knockdowns. As a transient assay, VIGS circumvents the generation of stable transgenic lines through laborious and ...
Wang, Zhengming +3 more
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Transcriptional silencing of homeotic genes in drosophila
BioEssays, 1995AbstractHomeotic genes are subject to transcriptional silencing, which prevents their expression in inappropriate body regions. Here, we shall focus on Drosophila, as little is known about this process in other organisms. Evidence is accumulating that silencing of Drosophila homeotic genes is conferred by two types of cis‐regulatory sequences ...
M, Bienz, J, Müller
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Post-transcriptional gene silencing activity of human GIGYF2
Biochemical and Biophysical Research Communications, 2016In mammalian post-transcriptional gene silencing, the Argonaute protein AGO2 indirectly recruits translation inhibitors, deadenylase complexes, and decapping factors to microRNA-targeted mRNAs, thereby repressing mRNA translation and accelerating mRNA decay.
Marie-Hélène, Kryszke +4 more
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Global analysis of siRNA‐mediated transcriptional gene silencing
BioEssays, 2005AbstractThe RNAi machinery is not only involved with post‐transcriptional degradation of messenger RNAs, but also used for targeting of chromatin changes associated with transcriptional silencing. Two recent papers determine the global patterns of gene expression and chromatin modifications produced by the RNAi machinery in fission yeast.(9, 10) The ...
Harsh H, Kavi +3 more
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RNA-Mediated Transcriptional Gene Silencing in Human Cells
2008The utilization of small interfering RNAs (siRNAs) represents a new paradigm in gene knockout technology. siRNAs can be used to knockdown the expression of a particular gene by targeting the mRNA in a post-transcriptional manner. While there are a plethora of reports applying siRNA-mediated post-transcriptional silencing (PTGS) therapeutically there ...
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Transcriptional gene silencing by short interfering RNAs.
Current opinion in molecular therapeutics, 2005Double-stranded RNA (dsRNA)-induced sequence-specific gene silencing in animals and plants is known as RNA interference. In mammalian cells, although long dsRNAs induce an interferon-mediated, non-specific gene silencing, short interfering RNAs (siRNAs) that are processed from long dsRNAs by Dicer can induce sequence-specific gene silencing.
Hiroaki, Kawasaki, Kazunari, Taira
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[Post-transcriptional gene silencing and virus resistance].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2001Post-transcriptional gene silencing(PTGS) is a defense mechanism of plants against foreign nucleic acids, such as virus infection. The mechanism results in sequence-specific degradation of nucleic acids, including endogenous mRNA, transgene mRNA and virus RNA.
F J, Wen, C X, Zhu
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