Results 261 to 270 of about 357,564 (302)
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Post-transcriptional gene silencing in neurons
Current Opinion in Neurobiology, 2004The techniques evolving from the rapidly developing field of small RNAs promise accessible approaches to dissecting cellular and molecular mechanisms of higher brain function. Here, a current overview of the technology is presented, along with an outline of how these approaches might help neuroscientists to more rapidly uncover the cellular and ...
Henry C, Zeringue +1 more
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Post-transcriptional gene silencing in plants
Journal of Cell Science, 2001Post-transcriptional gene silencing (PTGS) in plants is an RNA-degradation mechanism that shows similarities to RNA interference (RNAi) in animals. Indeed, both involve double-stranded RNA (dsRNA), spread within the organism from a localised initiating area, correlate with the accumulation of small interfering RNA (siRNA) and require putative RNA ...
Vaucheret, Herve +2 more
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RNA-directed transcriptional gene silencing in mammals
Trends in Genetics, 2005RNA interference is a highly conserved pathway mediating sequence-specific RNA degradation. In plants, the short RNA intermediates of this pathway can also drive transcriptional silencing of target genes by DNA methylation. Until recently, there was no evidence that a similar pathway operated in mammals; two new studies suggest that small RNAs can ...
Elizabeth H, Bayne, Robin C, Allshire
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Transcription and RNAi in heterochromatic gene silencing
Nature Structural & Molecular Biology, 2007Recent findings have challenged the longstanding belief that heterochromatin is an inert and transcriptionally inactive structure. Studies in organisms ranging from fission yeast to animals have found that noncoding RNAs transcribed from heterochromatic DNA repeats function in the assembly and function of heterochromatin. In this review, we discuss the
Bühler, Marc, Moazed, Danesh
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Reactivation of silenced genes and transcriptional therapy
Cytogenetic and Genome Research, 2003The purpose of this review is to discuss the potential role of “transcriptional therapy” to modulate the expression of target genes in order to treat monogenic as well as multifactorial disorders. In vitro and in vivo experiments with DNA demethylating and histone hyperacetylating drugs are currently performed in several laboratories on a variety of ...
P, Chiurazzi, G, Neri
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Spreading of post‐transcriptional gene silencing along the target gene promotes systemic silencing
The Plant Journal, 2004SummaryTransitive silencing and grafting‐induced gene silencing phenomena were combined to investigate whether a primary target β‐glucuronidase (gus) gene could promote the generation of systemic transitive silencing signals. Tobacco plants with hemizygous or homozygous silencer locus and in trans silenced primary target were used as a source of post ...
Rubén Darío, García-Pérez +2 more
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Transcriptional Gene Silencing Using Small RNAs
2009RNA interference is a potent gene silencing pathway initiated by short molecules of double-stranded RNA. Small interfering RNAs (siRNAs) with full sequence complementarity to mRNAs induce cleavage of their target transcripts in the cytoplasm. Recent evidence has shown, however, that siRNAs can also function in the nucleus of mammalian cells to affect ...
Daniel H, Kim, John J, Rossi
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Post-transcriptional gene silencing in plants by RNA
Plant Cell Reports, 2003RNA silencing, which is termed post-transcriptional gene silencing in plants, is an RNA degradation process through sequence-specific nucleotide interactions induced by double-stranded RNA. In plants, RNA silencing not only serves as a component of the defense mechanism, but also participates in the regulation of endogenous gene expression in a variety
H, Yu, P P, Kumar
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Genetic analysis of RNA-mediated transcriptional gene silencing
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2004The 'nuclear side' of RNA interference (RNAi) is increasingly recognized as an integral part of RNA-mediated gene silencing networks. Current data are consistent with the idea that epigenetic changes, such as DNA (cytosine-5) methylation and histone modifications, can be targeted to identical DNA sequences by short RNAs derived via Dicer cleavage of ...
Marjori, Matzke +6 more
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Post-transcriptional gene silencing by siRNAs and miRNAs
Current Opinion in Structural Biology, 2005Recent years have seen a rapid increase in our understanding of how double-stranded RNA (dsRNA) and 21- to 25-nucleotide small RNAs, microRNAs (miRNAs) and small interfering RNAs (siRNAs), control gene expression in eukaryotes. This RNA-mediated regulation generally results in sequence-specific inhibition of gene expression; this can occur at levels as
Witold, Filipowicz +3 more
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