Results 291 to 300 of about 1,124,626 (332)
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Transcriptional gene silencing as a tool for uncovering gene function in maize
Plant Journal, 2005SummaryTranscriptional gene silencing has broad applications for studying gene function in planta. In maize, a large number of genes have been identified as tassel‐preferred in their expression pattern, both by traditional genetic methods and by recent high‐throughput expression profiling platforms.
A Mark Cigáň, Erica Unger-Wallace
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Post-transcriptional gene silencing by double-stranded RNA
Nature Reviews Genetics, 2001Imagine being able to knock out your favourite gene with only a day's work. Not just in one model system, but in virtually any organism: plants, flies, mice or cultured cells. This sort of experimental dream might one day become reality as we learn to harness the power of RNA interference, the process by which double-stranded RNA induces the silencing ...
S M, Hammond, A A, Caudy, G J, Hannon
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Genetic analysis of RNA-mediated transcriptional gene silencing
Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 2004The 'nuclear side' of RNA interference (RNAi) is increasingly recognized as an integral part of RNA-mediated gene silencing networks. Current data are consistent with the idea that epigenetic changes, such as DNA (cytosine-5) methylation and histone modifications, can be targeted to identical DNA sequences by short RNAs derived via Dicer cleavage of ...
Marjori Matzke +2 more
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Transcriptional gene silencing in plants
Russian Journal of Genetics, 2010The review presents current data on molecular genetic mechanisms of suppression of the gene (transgene) expression in plants at the transcriptional level. The stages of RNA-directed DNA methylation are discussed in detail. Mutations affecting transcriptional gene inactivation without altering nucleotide sequence methylation are described.
T V, Marenkova, E V, Deĭneko
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Post-transcriptional gene silencing mutants
Plant Molecular Biology, 2000It has been known for more than a decade that increasing the gene copy number does not necessarily lead to increased gene activity. Plants have developed efficient mechanisms such as post-transcriptional gene silencing (PTGS) to regulate abnormal gene expression in a sequence-specific fashion.
Morel, J.B., Vaucheret, Herve
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Transcriptional Silencers: Driving Gene Expression with the Brakes On
Trends in Genetics, 2021Silencers are regulatory DNA elements that reduce transcription from their target promoters; they are the repressive counterparts of enhancers. Although discovered decades ago, and despite evidence of their importance in development and disease, silencers have been much less studied than enhancers.
Julian A, Segert +2 more
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Transcription and RNAi in heterochromatic gene silencing
Nature Structural & Molecular Biology, 2007Recent findings have challenged the longstanding belief that heterochromatin is an inert and transcriptionally inactive structure. Studies in organisms ranging from fission yeast to animals have found that noncoding RNAs transcribed from heterochromatic DNA repeats function in the assembly and function of heterochromatin. In this review, we discuss the
Bühler, Marc, Moazed, Danesh
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Reactivation of silenced genes and transcriptional therapy
Cytogenetic and Genome Research, 2003The purpose of this review is to discuss the potential role of “transcriptional therapy” to modulate the expression of target genes in order to treat monogenic as well as multifactorial disorders. In vitro and in vivo experiments with DNA demethylating and histone hyperacetylating drugs are currently performed in several laboratories on a variety of ...
P, Chiurazzi, G, Neri
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Post-transcriptional gene silencing in plants
Journal of Cell Science, 2001Post-transcriptional gene silencing (PTGS) in plants is an RNA-degradation mechanism that shows similarities to RNA interference (RNAi) in animals. Indeed, both involve double-stranded RNA (dsRNA), spread within the organism from a localised initiating area, correlate with the accumulation of small interfering RNA (siRNA) and require putative RNA ...
Vaucheret, Herve +2 more
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Post-transcriptional gene silencing in neurons
Current Opinion in Neurobiology, 2004The techniques evolving from the rapidly developing field of small RNAs promise accessible approaches to dissecting cellular and molecular mechanisms of higher brain function. Here, a current overview of the technology is presented, along with an outline of how these approaches might help neuroscientists to more rapidly uncover the cellular and ...
Henry C, Zeringue +1 more
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