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Transcriptional Regulation of Inflammasomes [PDF]

International Journal of Molecular Sciences, 2020
Inflammasomes are multimolecular complexes with potent inflammatory activity. As such, their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this review, we present the transcriptional regulation of inflammasome genes from sensors (e.g NLRP3) to substrates (e.g. IL-1β). Lineage-determining transcription
Maxence Cornut, Emilie Bourdonnay, Thomas Henry   +2 more
openaire   +5 more sources

Evolution of Regulated Transcription [PDF]

Cells, 2020
The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and precisely orchestrate gene expression programs.
Oleg V. Bylino, Airat N. Ibragimov, Yulii V. Shidlovskii   +2 more
openaire   +4 more sources

Transcriptional regulation [PDF]

WormBook, 2005
The regulation of transcription in C. elegans shares many similarities to transcription in other organisms. The details of how specific transcription factors bind to target promoters and act as either activators or repressors are still being examined in many cases, but an increasing number of factors and their binding sites are being characterized ...
Peter G, Okkema, Michael, Krause
openaire   +2 more sources

Transcriptional regulation of DC fate specification [PDF]

, 2020
Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further ...
Bosteels, Cedric, Scott, Charlotte
core   +1 more source

Adaptation with transcriptional regulation [PDF]

Scientific Reports, 2017
AbstractBiochemical adaptation is one of the basic functions that are widely implemented in biological systems for a variety of purposes such as signal sensing, stress response and homeostasis. The adaptation time scales span from milliseconds to days, involving different regulatory machineries in different processes.
Shi, Wenjia, Xiong, Liyang, Zhang, Mingyue, Tang, Chao, Ma, Wenzhe   +4 more
openaire   +4 more sources

Dynamics of transcriptional and post-transcriptional regulation [PDF]

Briefings in Bioinformatics, 2020
AbstractDespite gene expression programs being notoriously complex, RNA abundance is usually assumed as a proxy for transcriptional activity. Recently developed approaches, able to disentangle transcriptional and post-transcriptional regulatory processes, have revealed a more complex scenario.
Furlan M, De Pretis S, Pelizzola M
openaire   +3 more sources

Optogenetic regulation of transcription [PDF]

BMC Neuroscience, 2018
Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the signal to regulate gene transcription, and its ...
Olga Nazarenko, Istvan Stadler, S. Bui, Nikolai Kondratev, Ancha Baranova, Tatyana Shapiro, Evgeniya Kananykhina, Max Myakishev-Rempel, Oksana Polesskaya, Frances Barg Nardia, Vladimir Kornienko, Raymond J. Lanzafame, Vikas Chandhoke   +12 more
openaire   +4 more sources

Transcriptional Regulation of Osteoblasts [PDF]

Cells Tissues Organs, 2007
The differentiation of osteoblasts from mesenchymal precursors requires a series of cell fate decisions controlled by a hierarchy of transcription factors. These include RUNX2, Osterix (OSX), ATF4 and a large number of nuclear coregulators. During bone development, initial RUNX2 expression coincides with the formation of mesenchymal condensations and ...
Franceschi, Renny T., Ge, Chunxi, Xiao, Guozhi, Roca, Hernan, Jiang, Di   +4 more
openaire   +7 more sources

Noise processing by microRNA-mediated circuits: The Incoherent Feed-Forward Loop, revisited [PDF]

, 2016
The intrinsic stochasticity of gene expression is usually mitigated in higher eukaryotes by post-transcriptional regulation channels that stabilise the output layer, most notably protein levels. The discovery of small non-coding RNAs (miRNAs) in specific
De Martino, Andrea, Di Patti, Francesca, Grigolon, Silvia, Marinari, Vincenzo   +3 more
core   +7 more sources

The role of input noise in transcriptional regulation [PDF]

, 2007
Even under constant external conditions, the expression levels of genes fluctuate. Much emphasis has been placed on the components of this noise that are due to randomness in transcription and translation; here we analyze the role of noise associated ...
A Bar–Even, AA Verveen, AA Verveen, AM Walczak, C Zhao, CF Stevens, DS Burz, E Ozbudak, E Schneidman, F Conti, FJ Sigworth, FJ Sigworth, Gašper Tkačik, H Lecar, H Lecar, HB Barlow, HB Barlow, HC Berg, I Golding, J Paulsson, J Reinitz, JM Pedraza, JM Raser, JR Newman, JS van Zon, M Ptashne, MB Elowitz, N Rosenfeld, P Fatt, P Fatt, PS Swain, PV Pedone, RL Winston, Rory Edward Morty, S Hecht, S Hooshangi, SE Luria, T Gregor, T Gregor, Thomas Gregor, W Bialek, W Bialek, W Bialek, W Bialek, William Bialek, WJ Blake, X Ma   +46 more
core   +10 more sources