Results 31 to 40 of about 1,358,415 (326)

ZEB1 protects skeletal muscle from damage and is required for its regeneration

Nature Communications, 2019
Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role ...
Laura Siles, Chiara Ninfali, Marlies Cortés, Douglas S. Darling, Antonio Postigo   +4 more
doaj   +1 more source

Transcriptional Regulation: a Genomic Overview [PDF]

, 2002
The availability of the Arabidopsis thaliana genome sequence allows a comprehensive analysis of transcriptional regulation in plants using novel genomic approaches and methodologies. Such a genomic view of transcription first necessitates the compilation
Riechmann, José Luis
core   +2 more sources

NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. [PDF]

, 2009
BackgroundThe molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin.
Amini, Fariba, Bruneau, Benoit G, Coles, John, Hornberger, Lisa K, Riazi, Ali M, Takeuchi, Jun K, Van Arsdell, Glen S, Zaidi, Syed Hassan   +7 more
core   +5 more sources

Organellar carbon metabolism is co-ordinated with distinct developmental phases of secondary xylem [PDF]

, 2019
Subcellular compartmentation of plant biosynthetic pathways in the mitochondria and plastids requires coordinated regulation of nuclear encoded genes, and the role of these genes has been largely ignored by wood researchers. In this study, we constructed
Fierro Gutierrez, Ana Carolina Elisa, Marchal, Kathleen, Mizrachi, Eshchar, Myburg, Alexander A, Pinard, Desré   +4 more
core   +2 more sources

ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes [PDF]

, 2007
ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets.
A. A. Ferrando, A. A. Margolin, A. Califano, Ashburner, Basso, Buck, Buck, Ferrando, G. Stolovitzky, Gibbons, Glynn, Hughes, Keles, Kim, Lee, Li, Matys, Miele, Odom, P. Sumazin, Palomero, Palomero, Pelengaris, Qi, Ren, Sandelin, T. Palomero, Weng   +27 more
core   +3 more sources

An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression

Genome Biology, 2018
Background The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin ...
Yufeng Qin, John D. Roberts, Sara A. Grimm, Fred B. Lih, Leesa J. Deterding, Ruifang Li, Kaliopi Chrysovergis, Paul A. Wade   +7 more
doaj   +1 more source

Characterization of an induced pluripotent stem cell line (IMBPASi001-A) derived from fibroblasts of a patient affected by Wolfram Syndrome

Stem Cell Research, 2020
Wolfram Syndrome is a rare, autosomal recessive genetic disorder with clinical symptoms appearing in early childhood. Here, we report a generation of iPSCs from fibroblasts of a patient affected by this disease.
Dawid P. Grzela, Beata Marciniak, Lukasz Pulaski   +2 more
doaj   +1 more source

Transcriptional and Post-Transcriptional Regulation of Autophagy

Cells, 2022
Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis.
Qiuqin Ma, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li, Ling Tian   +5 more
doaj   +1 more source

Essential Roles of SATB1 in Specifying T Lymphocyte Subsets

Cell Reports, 2017
T cell receptor (TCR) signaling by MHC class I and II induces thymocytes to acquire cytotoxic and helper fates via the induction of Runx3 and ThPOK transcription factors, respectively.
Kiyokazu Kakugawa, Satoshi Kojo, Hirokazu Tanaka, Wooseok Seo, Takaho A. Endo, Yohko Kitagawa, Sawako Muroi, Mari Tenno, Nighat Yasmin, Yoshinori Kohwi, Shimon Sakaguchi, Terumi Kowhi-Shigematsu, Ichiro Taniuchi   +12 more
doaj   +1 more source

Emerging Roles of PRDM Factors in Stem Cells and Neuronal System: Cofactor Dependent Regulation of PRDM3/16 and FOG1/2 (Novel PRDM Factors)

Cells, 2020
PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) (PR) homologous domain containing (PRDM) transcription factors are expressed in neuronal and stem cell systems, and they exert ...
Paweł Leszczyński, Magdalena Śmiech, Emil Parvanov, Chisato Watanabe, Ken-ichi Mizutani, Hiroaki Taniguchi   +5 more
doaj   +1 more source