Results 31 to 40 of about 1,265,836 (379)

Functional Characteristics of Gene Expression Motifs with Single and Dual Strategies of Regulation [PDF]

Biomed. Phys. Eng. Express, 2 , 025009(2016), 2016
Transcriptional regulation by transcription factors and post-transcriptional regulation by microRNAs constitute two major modes of regulation of gene expression. While gene expression motifs incorporating solely transcriptional regulation are well investigated, the dynamics of motifs with dual strategies of regulation, i.e., both transcriptional and ...
arxiv   +1 more source

Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis [PDF]

, 2003
The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis ...
Behrendt N., Bianchi E., Borglum A.D., Boyd D., Chapman H.A., Conese M., Cubellis M.V., Duffy M.J., Duffy M.J., Ellis V., Hollas W., Kariko K., Kook Y.H., Lakka S.S., Langer D.J., Leupold J.H., Lund L.R., Means A.L., Min H.Y., Mohanam S., Nekarda H., Pedersen H., Pyke C., Pyke C., Quattrone A., Resnati M., Roldan A., Schewe D., Shetty S., Soravia E., Suh T., Xue W.   +31 more
core   +1 more source

Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene

Nature Communications, 2018
The commitment of helper and cytotoxic lineages for CD4 and CD8 T cells, respectively, is associated with the regulation of Cd4 gene expression. Here the authors show that an intronic silencer, S4, has differential effects and synergy with the RUNX ...
Satoshi Kojo, Nighat Yasmin, Sawako Muroi, Mari Tenno, Ichiro Taniuchi   +4 more
doaj   +1 more source

Challenges and Advances in the Taxonomy of Deep-Sea Peracarida: From Traditional to Modern Methods

Frontiers in Marine Science, 2022
As one of the oldest branches of biology, taxonomy deals with the identification, classification and naming of living organisms, using a variety of tools to explore traits at the morphological and molecular level.
Inmaculada Frutos, Stefanie Kaiser, Łukasz Pułaski, Łukasz Pułaski, Maciej Studzian, Maciej Studzian, Magdalena Błażewicz   +6 more
doaj   +1 more source

Author Correction: Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

Nature Communications, 2019
The original version of this Article contained an error in the author affiliations. Affiliation 5 incorrectly read ‘Laboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR), Suite, Hyogo 565-0874, Japan ...
Chizuko Miyamoto, Satoshi Kojo, Motoi Yamashita, Kazuyo Moro, Georges Lacaud, Katsuyuki Shiroguchi, Ichiro Taniuchi, Takashi Ebihara   +7 more
doaj   +1 more source

Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation

Journal of Cardiovascular Development and Disease, 2023
The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized by a squamous cell epithelium resting on the myocardium ...
Rita Carmona, Carmen López-Sánchez, Virginio Garcia-Martinez, Virginio Garcia-López, Ramón Muñoz-Chápuli, Estefanía Lozano-Velasco, Diego Franco   +6 more
doaj   +1 more source

MicroRNAs preferentially target the genes with high transcriptional regulation complexity [PDF]

Biochem Biophys Res Commun., 352:733-738, 2007, 2006
Over the past few years, microRNAs (miRNAs) have emerged as a new prominent class of gene regulatory factors that negatively regulate expression of approximately one-third of the genes in animal genomes at post-transcriptional level. However, it is still unclear why some genes are regulated by miRNAs but others are not, i.e.
arxiv   +1 more source

Transcriptional Regulation by P53 [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal. Arguably p53's most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell's RNA polymerase II (RNAP II ...
Carol Prives, Rachel Beckerman
openaire   +3 more sources

Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

Nature Communications, 2019
Group 2 innate lymphoid cells (ILC2) are important mediators for allergy, but how ILC2 are regulated under chronic inflammation is still unclear. Here the authors show that Runx transcription factors, which normally suppresses ILC2 activation at steady ...
Chizuko Miyamoto, Satoshi Kojo, Motoi Yamashita, Kazuyo Moro, Georges Lacaud, Katsuyuki Shiroguchi, Ichiro Taniuchi, Takashi Ebihara   +7 more
doaj   +1 more source

Transcriptional and Post-Transcriptional Regulation of Autophagy

Cells, 2022
Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis.
Qiuqin Ma, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li, Ling Tian   +5 more
doaj   +1 more source