Results 61 to 70 of about 4,769,934 (397)
Nucleic Acids Research, 2019 A complex and highly orchestrated gene expression program chiefly establishes the properties that define the adipocyte phenotype, in which the vast majority of factors are involved in transcriptional regulation.
Tongxing Song +9 more
semanticscholar +1 more source
Nature Communications, 2017 CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper ...
Satoshi Kojo +18 more
doaj +1 more source
mSphere, 2016 In view of emerging drug resistance among bacterial pathogens, including Mycobacterium tuberculosis, the development of novel therapeutic strategies is increasingly being sought.
Pallavi Chandra +4 more
doaj +1 more source
HTRIdb: an open-access database for experimentally verified human transcriptional regulation interactions [PDF]
, 2012 Background: The modeling of interactions among transcription factors (TFs) and their respective target genes (TGs) into transcriptional regulatory networks is important for the complete understanding of regulation of biological processes.
Luiz A. Bovolenta +2 more
core +4 more sources
Transcriptional Regulation of Macrophages Polarization by MicroRNAs
Frontiers in Immunology, 2018 Diversity and plasticity are the hallmarks of cells from the monocyte–macrophage lineage. Macrophages undergo classical M1 or alternative M2 activation in response to the microenvironment signals.
Heng Li +4 more
semanticscholar +1 more source
Transcriptional Regulators of Angiogenesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Angiogenesis, the process by which new blood vessels develop from a pre-existing vascular network, is essential for normal development and in certain physiological states. Inadequate or excessive angiogenesis has been incriminated in a number of pathologic states.
Anne Hamik, Baiqiu Wang, Mukesh K. Jain
openaire +2 more sources
Cell-type specific analysis of translating RNAs in developing flowers reveals new levels of control [PDF]
, 2010 Determining both the expression levels of mRNA and the regulation of its translation is important in understanding specialized cell functions. In this study, we describe both the expression profiles of cells within spatiotemporal domains of the ...
Elliot M Meyerowitz +4 more
core +2 more sources
Frontiers in Plant Science, 2018 Plant cell walls provide structural support for growth and serve as a barrier for pathogen attack. Plant cell walls are also a source of renewable biomass for conversion to biofuels and bioproducts.
Jin Zhang +4 more
semanticscholar +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The odyssey of a regulated transcript [PDF]
RNA, 2000 The transcript of the Saccharomyces cerevisiae gene, RPL30, is subject to regulated splicing and regulated translation, due to a structure that interacts with its own product, ribosomal protein L30. We have followed the fate of the regulated RPL30 transcripts in vivo.
Josep Vilardell +3 more
openaire +3 more sources