Transcriptome‐wide association study

Results 121 to 130 of about 40,064,733 (237)

Deciphering the peripheral immune landscape of Alzheimer’s disease through integrated multi-omics research and cohort validation

Frontiers in Immunology
ObjectiveThis study investigated molecular drivers of AD-associated peripheral immune dysregulation to identify pathogenic genes and therapeutic targets for precision diagnosis and intervention.MethodsA large-scale GWAS meta-analysis (n = 894,710) was ...
Shi Lv +18 more
doaj +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li +9 more
wiley +1 more source

Transcriptome-wide comparisons.

, 2017
Comparisons of transcriptome-scale SNV profiles for every cell line investigated, with a colour gradient for increasing concordance. The average concordance of non-related cell lines is 67.9%.
Susan Kennedy (424972) +7 more
core +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk +11 more
wiley +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu +8 more
wiley +1 more source

Decoding the genetic architecture of women reproductive aging: multi-omic integration identifies novel loci and mechanistic pathways for precision intervention

BMC Genomics
Currently, little is understood about the genetic architecture underlying Genome-wide association study (GWAS)-related traits that influence the reproductive ageing of women.
Yi-fan Kang, Jian-rong Liu
doaj +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source

Comprehensive GWAS and transcriptome analysis discovered new candidate genes for powdery mildew response in pea (Pisum sativum L.)

BMC Plant Biology
Background Pea powdery mildew is a major disease that causes substantial yield losses and reduces crop quality. Identifying new resistance genes is essential for developing cultivars with durable resistance and high productivity.
Xiaojuan Zhong +6 more
doaj +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez +16 more
wiley +1 more source

Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations ...
A Cox (65204) +100 more
core

transcriptome-wide association study
genome-wide association study
transcriptome

transcriptome-wide association study twas
genome-wide association study gwas
proteome-wide association study

gene expression
susceptibility genes
genome‐wide association study