Results 121 to 130 of about 181,971 (294)
Harmony in transcripts: a systematic literature review of transcriptome-wide association studies
Journal of Engineering and Applied ScienceTranscriptome-wide association studies (TWAS) goal is to better understand the etiology of diseases and develop preventative and therapeutic approaches by examining the connections between genetic variants and phenotypes while overcoming the limitations ...
Mahinaz A. Mashhour +3 more
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Transcriptome-Wide Association Study Identifies Susceptibility Loci and Genes for Age at Natural Menopause [PDF]
, 2018 Jiajun Shi +9 more
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Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen +18 more
wiley +1 more source
A Framework for Transcriptome-Wide Association Studies in Breast Cancer in Diverse Study Populations [PDF]
, 2019 Arjun Bhattacharya +5 more
openalex +1 more source
Transcriptome-wide association study identifies novel genes associated with bone mineral density and lean body mass in children [PDF]
, 2022 Jiawen Xu +6 more
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Arthritis Care &Research, Accepted Article.Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla +13 more
wiley +1 more source
Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development
Advanced Biology, EarlyView.Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng +10 more
wiley +1 more source
BMC GenomicsCurrently, little is understood about the genetic architecture underlying Genome-wide association study (GWAS)-related traits that influence the reproductive ageing of women.
Yi-fan Kang, Jian-rong Liu
doaj +1 more source
Model Checking via Testing for Direct Effects in Mendelian Randomization and Transcriptome-wide Association Studies [PDF]
, 2021 Yangqing Deng, Wei Pan
openalex +1 more source