Results 121 to 130 of about 345,542 (371)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Elucidating the susceptibility to breast cancer: an in-depth proteomic and transcriptomic investigation into novel potential plasma protein biomarkers

Frontiers in Molecular Biosciences
Objectives: This study aimed to identify plasma proteins that are associated with and causative of breast cancer through Proteome and Transcriptome-wide association studies combining Mendelian Randomization.Methods: Utilizing high-throughput datasets, we
Yang Wang, Kexin Yi, Baoyue Chen, Bailin Zhang, Gao Jidong, Gao Jidong   +5 more
doaj   +1 more source

Power analysis of transcriptome-wide association study: implications for practical protocol choice

bioRxiv, 2020
The transcriptome-wide association study (TWAS) has emerged as one of several promising techniques for integrating multi-scale ‘omics’ data into traditional genome-wide association studies (GWAS).
Bowei Ding, Chen Cao, Qing Li, Devin Kwok, Jingjing Wu, Q. Long   +5 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays. [PDF]

, 2019
Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers.
Bandillo, Nonoy B, Buckler, Edward S, Diepenbrock, Christine H, Gore, Michael A, Kremling, Karl AG   +4 more
core   +1 more source

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms [PDF]

, 2017
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await ...
A Schröder, Abdulla al Shafi Majumder, Adam S Butterworth, Alex P Reiner, Anders Malarstig, Andrew D Johnson, Anne Justice, Anne Tybjærg-Hansen, AP Levy, AP Morris, AP Reiner, Arshed A Quyyumi, Asif Rasheed, AV Segrè, Benjamin B Sun, BF Voight, BL Harry, BP Fairfax, Børge G Nordestgaard, C Moore, Cara L Carty, Carl J Pepine, Chao A Hsiung, Charles Kooperberg, CJ Willer, D Qu, Daniel F Freitag, Daniel J Rader, Daniel R Barnes, Danish Saleheen, Devin Absher, Dewan S Alam, Dirk S Paul, DM Greenawalt, E Grundberg, EE Schadt, Elias L Salfati, Emanuele Di Angelantonio, Eric B Fauman, Eric Boerwinkle, F Innocenti, GA Roth, GR Abecasis, H Kirsten, H Lin, H Schunkert, Heribert Schunkert, HJ Westra, Hugh Watkins, I Holme, I-Te Lee, J Chen, J Dennis, J Erdmann, J Ernst, J Ernst, J Yang, Jeanette Erdmann, Jemma B Wilk, Jerome I Rotter, Joanna M M Howson, John A Spertus, John D Eicher, John Danesh, JR Privratsky, JR Staley, Julie A Johnson, Jyh-Ming J Juang, Kari E North, Katrine L Rasmussen, Kent D Taylor, Kristin Young, LD Ward, Lindsay L Waite, LM Boettger, Lucia A Hindorff, M Arnold, M Narahara, M Uhlen, M Uhlén, Mariaelisa Graff, N Franceschini, Nilesh J Samani, NJ Samani, NL Smith, Nora Franceschini, O Franzén, P Surendran, P Zanoni, Panos Deloukas, Philippe Frossard, Pia R Kamstrup, Praveen Surendran, R Goel, Rajiv Chowdhury, Ren-Hua Chung, Robin Young, Ron Do, S Purcell, Sekar Kathiresan, Stanley L Hazen, Steven Buyske, Sune F Nielsen, T Lappalainen, T Zeller, Themistocles L Assimes, Thomas Quertermous, TL Assimes, TM Teslovich, Tzung-Dau Wang, Ulrike Peters, V Nanda, W Tang, Wayne H H Sheu, Weang-Kee Ho, Wei Zhao, Wei-Yu Lin, Wen-Jane Lee, WJ Astle, X Zhang, X Zhou, Xiuqing Guo, Yi-Jen Hung, Yii-Der Ida Chen, Ying-Hsiang Chen, Z Wang, Å Johansson   +126 more
core   +2 more sources

Multi-tissue transcriptome-wide association study identifies eight candidate genes and tissue-specific gene expression underlying endometrial cancer susceptibility

Communications Biology, 2021
Genome-wide association studies (GWAS) have revealed sixteen risk loci for endoemtrial cancer but the identification of candidate susceptibility genes remains challenging.
P. Kho, Xuemin Wang, G. Cuéllar-Partida, T. Dörk, E. Goode, D. Lambrechts, R. Scott, A. Spurdle, T. O’Mara, Dylan M Glubb   +9 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

The Sorghum bicolor reference genome: improved assembly, gene annotations, a transcriptome atlas, and signatures of genome organization. [PDF]

, 2017
Sorghum bicolor is a drought tolerant C4 grass used for the production of grain, forage, sugar, and lignocellulosic biomass and a genetic model for C4 grasses due to its relatively small genome (approximately 800 Mbp), diploid genetics, diverse ...
Amirebrahimi, Mojgan, Grimwood, Jane, Jenkins, Jerry, Kennedy, Megan, Mattison, Ashley, McCormick, Ryan F, McKinley, Brian, Morishige, Daryl T, Mullet, John E, Schmutz, Jeremy, Shu, Shengqiang, Sims, David, Sreedasyam, Avinash, Truong, Sandra K, Weers, Brock D   +14 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source