Results 141 to 150 of about 345,542 (371)

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes. [PDF]

, 2018
Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes.
A Battle, A Krishnan, A Perry, A Schroeder, A Sugathan, A Venter, AJ Willsey, AM Wetherby, AR McIntosh, AR Pfenning, AT Hilliard, BS Abrahams, C Demopoulos, C Lord, CR Genovese, Cynthia Carter Barnes, DA Rossignol, DH Geschwind, DH Geschwind, DL Vargas, E Redcay, E Redcay, EA Boyle, EJ Greenblatt, Eric Courchesne, F Happé, G Dehaene-Lambertz, G Hickok, G Konopka, G Konopka, H Tager-Flusberg, HR Cremers, I Voineagu, J Cotney, JA Kosmicki, JA Miller, JC Darnell, JD Storey, JI Berman, JT Morgan, K Gotham, K Pierce, K Pierce, K Pierce, Karen Pierce, L Hippolyte, Linda Lopez, Lisa Eyler, LT Eyler, M Chikina, M Lek, MC Lai, MC Oldham, MCN Marchetto, ME Ritchie, Michael V. Lombardo, MM Kjelgaard, MV Lombardo, Nathan E. Lewis, NN Parikshak, NN Parikshak, NR Wray, P Du, P Howlin, P Langfelder, P Langfelder, P Szatmari, R Bernier, RC Gentleman, Richard A. I. Bethlehem, RJ Kelleher III, S Kapur, S Rubeis De, S Sandin, SJ Sanders, T Pramparo, T Pramparo, T Yarkoni, Tiziano Pramparo, Vahid Gazestani, Varun Warrier, X Liu, X Nuttle   +82 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives

Cell & Bioscience
AbstractCrohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS) can help identify susceptibility genes associated with pathogenesis and disease behavior ...
Keyu Jia, Jun Shen
openaire   +3 more sources

Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors. [PDF]

, 2019
Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies.
Abrams, Gary, Chesney, Margaret, Conley, Yvette P, Kober, Kord M, Levine, Jon D, Melisko, Michelle, Miaskowski, Christine, Paul, Steven M, Schumacher, Mark, Topp, Kimberly   +9 more
core  

Modeling the functional genomics of autism using human neurons. [PDF]

, 2012
Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation,
Chen, L, Gao, F, Gao, K, Geschwind, DH, Konopka, G, Lowe, JK, Lu, D, Mukamel, Z, Osborn, GE, Rosen, E, Wexler, E   +10 more
core   +1 more source

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

Scientific Reports, 2020
Genome-wide association studies (GWAS) for late stage age-related macular degeneration (AMD) have identified 52 independent genetic variants with genome-wide significance at 34 genomic loci.
Tobias Strunz, Susette Lauwen, C. Kiel, Lars G. Wilmar Jessica N. Cooke Felix Sebanti Jennifer Fritsche Igl Bailey Grassmann Sengupta Bragg-Gresh, L. Fritsche, W. Igl, J. C. Bailey, F. Grassmann, Sebanti Sengupta, J. Bragg-Gresham, K. Burdon, S. Hebbring, Cindy Wen, Mathias Gorski, Ivana K. Kim, David Cho, D. Zack, E. Souied, H. Scholl, E. Bala, Kristine E. Lee, D. J. Hunter, Rebecca J. Sardell, Paul A. Mitchell, J. Merriam, V. Cipriani, Joshua D Hoffman, T. Schick, Y. Lechanteur, R. Guymer, Matthew P Johnson, Yingda Jiang, Chloe M. Stanton, Gabriëlle H S Buitendijk, Xiaowei Zhan, Alan M. Kwong, Alexis Boleda, M. Brooks, L. Gieser, R. Ratnapriya, K. Branham, Johanna R. Foerster, J. Heckenlively, M. Othman, B. Vote, Helena H. Liang, E. Souzeau, I. McAllister, T. Isaacs, Janette Hall, Stewart R. Lake, D. Mackey, I. Constable, J. Craig, Terrie E. Kitchner, Zhenglin Yang, Z. Su, Hongrong Luo, Daniel Chen, Ouyang Hong, Ken Flagg, Danni Lin, Guanping Mao, H. Ferreyra, K. Stark, C. N. Strachwitz, A. Wolf, C. Brandl, G. Rudolph, M. Olden, M. Morrison, Denise J. Morgan, M. Schu, Jeeyun Ahn, G. Silvestri, E. Tsironi, K. Park, L. Farrer, A. Orlin, A. Brucker, Mingyao Li, C. Curcio, S. Mohand-Saïd, J. Sahel, I. Audo, M. Benchaboune, A. Cree, C. Rennie, S. Goverdhan, M. Grunin, Shira Hagbi-Levi, P. Campochiaro, N. Katsanis, F. Holz, Frédéric Blond, H. Blanché, J. Deleuze, R. Igo, Barbara Truitt, N. Peachey, S. Meuer, Chelsea E. Myers, Emily L. Moore, R. Klein, M. Hauser, E. Postel, Monique D. Courtenay, S. G. Schwartz, Jaclyn L Kovach, W. Scott, G. Liew, Ava G. Tfan, B. Gopinath, J. Merriam, R. T. Smith, J. Khan, Humma Shahid, A. Moore, J. McGrath, R. Laux, M. Brantley, A. Agarwal, Lebriz Ersoy, A. Caramoy, T. Langmann, Nicole T. M. Saksens, E. K. Jong, C. Hoyng, M. Cain, A. Richardson, T. Martin, J. Blangero, D. Weeks, B. Dhillon, C. Duijn, K. Doheny, Jane M. Romm, C. Klaver, C. Hayward, M. Gorin, M. Klein, P. Baird, A. D. Hollander, S. Fauser, J. Yates, R. Allikmets, Jie-Jin Wang, D. Schaumberg, B. Klein, S. Hagstrom, I. Chowers, A. Lotery, T. Léveillard, Kang Zhang, M. Brilliant, A. Hewitt, A. Swaroop, E. Chew, M. Pericak-Vance, M. DeAngelis, D. Stambolian, J. Haines, S. Iyengar, Bernhard H.F. Weber, G. Abecasis, I. Heid, A. D. Hollander, Bernhard H.F. Weber   +167 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits [PDF]

, 2021
Bryce Rowland, Sanan Venkatesh, Manuel Tardáguila, Jia Wen, Jonathan D. Rosen, Amanda L. Tapia, Quan Sun, Mariaelisa Graff, Dragana Vuckovic, Guillaume Lettre, Vijay G. Sankaran, Alexander P. Reiner, Nicole Soranzo, Jennifer E. Huffman, Georgios Voloudakis, Panos Roussos, Laura M. Raffield, Yun Li   +17 more
openalex   +1 more source

Integrating brain proteomes and genetics to identify novel risk genes in chronic widespread musculoskeletal pain

Scientific Reports
Chronic widespread musculoskeletal pain (CWP), a core symptom of fibromyalgia, is a complex condition with an unclear pathogenesis. Despite findings from genome-wide association studies (GWAS), translating genetic risk variants into therapeutic targets ...
Zhisen Dai, Yanlin Wu, Huaqing Huang, Huizhe Zheng   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source