Results 191 to 200 of about 181,971 (294)

Transcriptome-wide association study reveals novel susceptibility genes for coronary atherosclerosis. [PDF]

Front Cardiovasc Med, 2023
Zhao Q, Liu R, Chen H, Yang X, Dong J, Bai M, Lu Y, Leng Y.   +7 more
europepmc   +1 more source

Additional file 13 of Genome-wide association study and transcriptome analysis dissect the genetic control of silique length in Brassica napus L.

, 2021
Jia Wang, Yueling Fan, Lin Mao, Cunmin Qu, Kun Lu, Jiana Li, Liezhao Liu   +6 more
openalex   +1 more source

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

Advanced Science, EarlyView.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao, Yu‐Bo Ma, Rui‐Hong Xia, Zheng‐Chen Jiang, Ying Zhou, Ya‐Nan Wang, Meng‐Yan Yang, Jing‐Jie Dai, Tao Zhu, Li‐Bin Pan, Li Yuan   +10 more
wiley   +1 more source

Transcriptome-wide association study reveals candidate causal genes for lumbar spinal stenosis. [PDF]

Bone Joint Res, 2023
Xu J, Si H, Zeng Y, Wu Y, Zhang S, Shen B.   +5 more
europepmc   +1 more source

supplemental data for manuscript Genome wide association studies and transcriptome changes during acclimation

, 2020
David P. Horvath
openalex   +2 more sources

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Transcriptome-wide association study identifies novel candidate susceptibility genes for migraine. [PDF]

HGG Adv, 2023
Meyers TJ, Yin J, Herrera VA, Pressman AR, Hoffmann TJ, Schaefer C, Avins AL, Choquet H.   +7 more
europepmc   +1 more source

RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility

Advanced Science, EarlyView.
RAD21L1 is upregulated in human Sertoli cells to be transited to become spermatogonial stem cells by overexpressing DAZ family three genes. RAD21L1 is sufficient and effective for reprogramming Sertoli cells into human spermatogonial stem cells with high safety through DNA methylation.
Caimei He, Yinghong Cui, Wei Chen, Chunyun Li, Zuping He   +4 more
wiley   +1 more source

A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort. [PDF]

Biomedicines
Liu M, Li Z, Lu Y, Sun P, Chen Y, Yang L.   +5 more
europepmc   +1 more source

Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis. [PDF]

Arthritis Res Ther, 2023
Mei L, Zhang Z, Chen R, Liu Z, Ren X, Li Z.   +5 more
europepmc   +1 more source