Results 221 to 230 of about 181,971 (294)

webTWAS 2.0: update platform for identifying complex disease susceptibility genes through transcriptome-wide association study. [PDF]

Nucleic Acids Res
Cao C, Shao M, Wang J, Li Z, Chen H, You T, Li MJ, Ding Y, Zou Q.   +8 more
europepmc   +1 more source

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

Integrative Transcriptome-Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibility. [PDF]

Adv Sci (Weinh)
Liang Y, Xiong XY, Lin GW, Bai X, Li F, Ko JM, Zhou YH, Xu AY, Liu SQ, He S, Wei PP, Chen QY, Tang LQ, Wang VY, Mai HQ, Luo CL, Zeng Y, Lung ML, Ji M, Bei JX.   +19 more
europepmc   +1 more source

Subset-based method for cross-tissue transcriptome-wide association studies improves power and interpretability

Xinyu Guo, Nilanjan Chatterjee, Diptavo Dutta   +2 more
openalex   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

Advanced Science, EarlyView.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang, Yiran Fang, Xiatong Huang, Guichuang Ma, Qianqian Mao, Xiansheng Lu, Guangda Rong, Yunfang Yu, Yuanyuan Wang, Zhenhua Huang, Huiying Sun, Jiani Wu, Wenchao Gu, Na Huang, Jianhua Wu, Rui Zhou, Xiaoxiang Rong, Siting Zheng, Shaowei Li, Gaofeng Wang, Ling Wang, Wenjun Qiu, Luyang Jiang, Peng Luo, Yonggang Liu, Jianping Bin, Yulin Liao, Min Shi, Zuqiang Wu, Jiguang Wang, Wangjun Liao, Gang Chen, Dongqiang Zeng   +32 more
wiley   +1 more source

Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures. [PDF]

Turk J Gastroenterol
Wang J, Gao Q.
europepmc   +1 more source

Table S6 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma

Tiankai Xie, Josey C. Sorenson, Logan G. Spector, Nathan Pankratz, R. Stephanie Huang, Eiso Hiyama, Jenny N. Poynter, Gail E. Tomlinson, Carolina Armengol, Roland Kappler, Michael E. Scheurer, Eve Roman, Aurora Castellano, Michael A. Grotzer, David S. Ziegler, Saonli Basu, Erin L. Marcotte, Tianzhong Yang   +17 more
openalex   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

A cross-tissue transcriptome-wide association study identifies WDPCP as a potential susceptibility gene for coronary atherosclerosis. [PDF]

Atheroscler Plus
Hu X, Chen G, Yang X, Cui J, Zhang N.
europepmc   +1 more source

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism [PDF]

, 2019
Agrawal, Arpana, Harari, Oscar, Zeran, Li   +2 more
core   +1 more source