Results 221 to 230 of about 186,925 (248)

Gaining new insights into the etiology of ulcerative colitis through a cross-tissue transcriptome-wide association study. [PDF]

Front Genet
Ren S, Sun C, Zhai W, Wei W, Liu J.
europepmc   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Transcriptome-Wide Association Study of Idiopathic Pulmonary Fibrosis Survival Identifies <i>PTPN9</i> and <i>SNRPB2</i>. [PDF]

Am J Respir Crit Care Med
Hu X, Kim JS, Saferali A, Huang Y, Ma SF, Bingham GC, Bonham CA, Flores C, Castaldi P, Hersh CP, Cho MH, IPF Survival GWAS Consortium, Noth I, Manichaikul A.   +13 more
europepmc   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

A Single-Nucleus Transcriptome-Wide Association Study Implicates Novel Genes in Depression Pathogenesis. [PDF]

Biol Psychiatry
Zeng L, Fujita M, Gao Z, White CC, Green GS, Habib N, Menon V, Bennett DA, Boyle P, Klein HU, De Jager PL.   +10 more
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract. [PDF]

Front Ophthalmol (Lausanne)
Choquet H, Duot M, Herrera VA, Shrestha SK, Meyers TJ, Hoffmann TJ, Sangani PK, Lachke SA.   +7 more
europepmc   +1 more source

SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning. [PDF]

Nat Commun
Parrish RL, Buchman AS, Tasaki S, Wang Y, Avey D, Xu J, De Jager PL, Bennett DA, Epstein MP, Yang J.   +9 more
europepmc   +1 more source

A multi-tissue, splicing-based joint transcriptome-wide association study identifies susceptibility genes for breast cancer. [PDF]

Am J Hum Genet
Gao G, McClellan J, Barbeira AN, Fiorica PN, Li JL, Mu Z, Olopade OI, Huo D, Im HK.   +8 more
europepmc   +1 more source

Transcriptome-Wide Association Study Reveals Potentially Candidate Genes Responsible for Milk Production Traits in Buffalo. [PDF]

Int J Mol Sci
Wei K, Lu Y, Ma X, Duan A, Lu X, Abdel-Shafy H, Deng T.   +6 more
europepmc   +1 more source