Results 91 to 100 of about 8,166 (222)

Transcriptome-wide association study-derived genes as potential visceral adipose tissue-specific targets for type 2 diabetes

Diabetologia, 2023
Aims/hypothesis This study aimed to assess the causal relationship between visceral obesity and type 2 diabetes and subsequently to screen visceral adipose tissue (VAT)-specific targets for type 2 diabetes.
Haibo Tang, Jie Wang, Peizhi Deng, Yalan Li, Yaoquan Cao, B. Yi, Liyong Zhu, Shaihong Zhu, Yao Lu   +8 more
semanticscholar   +1 more source

Transcriptome-wide association study uncovers the role of essential genes in anthracycline-induced cardiotoxicity

npj Genomic Medicine, 2021
Anthracyclines are highly effective chemotherapeutic agents; however, their clinical utility is limited by severe anthracycline-induced cardiotoxicity (ACT).
Erika N. Scott, Galen E. B. Wright, Britt I. Drögemöller, Jafar S. Hasbullah, Erandika P. Gunaretnam, Fudan Miao, Amit P. Bhavsar, Fei Shen, Bryan P. Schneider, Bruce C. Carleton, Colin J. D. Ross   +10 more
doaj   +1 more source

Identification and validation of transcriptome-wide association study-derived genes as potential druggable targets for osteoarthritis

Bone & Joint Research
Aims Osteoarthritis (OA) is a widespread chronic degenerative joint disease with an increasing global impact. The pathogenesis of OA involves complex interactions between genetic and environmental factors.
Xindie Zhou, Xinjian Ye, Jiapei Yao, Xiaolong Lin, Yiping Weng, Yong Huang, Yaojun Lu, JingJing Shang, Luming Nong   +8 more
semanticscholar   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 84-88, January 2026.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration [PDF]

, 2020
Genome-wide association studies (GWAS) for late stage age-related macular degeneration (AMD) have identified 52 independent genetic variants with genome-wide significance at 34 genomic loci.
Bailey, Jessica N.Cooke, Blangero, John, Bragg-Gresham, Jennifer L., Fritsche, Lars G., Grassmann, Felix, Igl, Wilmar, Johnson, Matthew P., Kiel, Christina, Lauwen, Susette, Sengupta, Sebanti, Strunz, Tobias   +10 more
core   +2 more sources

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia

Alzheimer’s Research & Therapy
Background Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome.
Shuyi Guo, Jingjing Yang
doaj   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identifies Candidate Genes Associated With Idiopathic Pulmonary Fibrosis

Frontiers in Genetics, 2020
Idiopathic pulmonary fibrosis (IPF) is a type of scarring lung disease characterized by a chronic, progressive, and irreversible decline in lung function. The genetic basis of IPF remains elusive.
Weiming Gong, Ping Guo, Lu Liu, Qingbo Guan, Qingbo Guan, Qingbo Guan, Zhongshang Yuan   +6 more
doaj   +1 more source

Transcriptome-wide association study identifies new susceptibility genes for degenerative cervical spondylosis

Bone & Joint Research, 2023
AimsDegenerative cervical spondylosis (DCS) is a common musculoskeletal disease that encompasses a wide range of progressive degenerative changes and affects all components of the cervical spine.
Jiawen Xu, Haibo Si, Yi Zeng, Yuangang Wu, Shaoyun Zhang, Yuan Liu, Mingyang Li, Bin Shen   +7 more
doaj   +1 more source

FarmGTEx TWAS-server: An Interactive Web Server for Customized TWAS Analysis [PDF]

Transcriptome-wide association study (TWAS) is a powerful approach for investigating the molecular mechanisms linking genetic loci to complex phenotypes.
Bai, Zhonghao, Chen, Zitao, Fang, Lingzhao, Gao, Yahui, Li, Bingjie, Lin, Qing, Liu, George, Liu, Shuli, Pan, Yuchun, Teng, Jinyan, Wang, Qishan, Wu, Jun, Zhang, Zhe, Zhang, Zhe, Zhang, Zhenyang   +14 more
core   +1 more source

Novel insight into the aetiology of rheumatoid arthritis gained by a cross-tissue transcriptome-wide association study

RMD Open, 2022
Background Although genome-wide association studies (GWASs) have identified more than 100 loci associated with rheumatoid arthritis (RA) susceptibility, the causal genes and biological mechanisms remain largely unknown.
J. Ni, Peng Wang, K. Yin, Xiao-Ke Yang, H. Cen, Cong Sui, Guo-Cui Wu, Haifeng Pan   +7 more
semanticscholar   +1 more source