Results 91 to 100 of about 6,140 (191)

scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type–specific transcriptome-wide association study framework

bioRxiv
Transcriptome-wide association studies (TWAS) help identify disease causing genes, but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type–specific expression data. Here we propose
Yichao Zhou, Temidayo Adeluwa, Lisha Zhu, Sofia Salazar-Magaña, Sarah Sumner, Hyunki Kim, Saideep Gona, F. Nyasimi, Rohit Kulkarni, Joseph E. Powell, Ravi Madduri, Boxiang Liu, Mengjie Chen, Hae Kyung Im   +13 more
semanticscholar   +1 more source

A method to adjust for the uncertainty of predicted expression in transcriptome-wide association study

bioRxiv
Transcriptome-wide association study (TWAS) is a powerful approach to identifying novel genes associated with complex phenotypes. Standard TWAS approaches build a prediction model for the genetic component of expression based on reference transcriptome ...
Arunabha Majumdar, T. Haldar
semanticscholar   +1 more source

A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD

Scientific Reports
Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder with environmental factors being the primary risk determinants. However, genetic factors also substantially contribute to the susceptibility and progression of COPD ...
Guanglei Chen, Yaxian Jin, Cancan Chu, Yuhao Zheng, Changfu Yang, Yunzhi Chen, Xing Zhu   +6 more
semanticscholar   +1 more source

UTMOST, A Novel Single And Cross-Tissue TWAS (Transcriptome Wide Association Study), Reveals New ASD (Autism Spectrum Disorder) Associated Genes [PDF]

, 2020
Cristina Rodriguez Fontenla, Ángel Carracedo, Cristina Rodriguez Fontenla, Ángel Carracedo   +3 more
openalex   +1 more source

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

Nature Genetics, 2016
Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 ...
A. Gusev, Nicholas Mancuso, H. Won, M. Kousi, H. Finucane, Yakir A. Reshef, Lingyun Song, Alexias Safi, S. Mccarroll, B. Neale, R. Ophoff, M. O’Donovan, G. Crawford, D. Geschwind, N. Katsanis, P. Sullivan, B. Pasaniuc, A. Price   +17 more
semanticscholar   +1 more source

Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

Cancer Medicine, 2018
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC).
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han   +5 more
doaj   +1 more source

Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives

Cell & Bioscience
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS)
Keyu Jia, Jun Shen
doaj   +1 more source

Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes

Nature Communications
Genome-wide association studies have suggested numerous colorectal cancer (CRC) susceptibility genes, but their causality and therapeutic potential remain unclear.
Emma Hazelwood, Daffodil M. Canson, Benedita Deslandes, Xuemin Wang, Pik Fang Kho, Danny Legge, Andrei-Emil Constantinescu, Matthew A. Lee, D. Timothy Bishop, Andrew T. Chan, Stephen B. Gruber, Jochen Hampe, Loic Le Marchand, Michael O. Woods, Rish K. Pai, Stephanie L. Schmit, Jane C. Figueiredo, Wei Zheng, Jeroen R. Huyghe, Neil Murphy, Marc J. Gunter, Tom G. Richardson, Vicki L. J. Whitehall, Emma E. Vincent, Dylan M. Glubb, Tracy A. O’Mara   +25 more
doaj   +1 more source

Identification and validation of transcriptome-wide association study-derived genes as potential druggable targets for osteoarthritis

Bone & Joint Research
Aims Osteoarthritis (OA) is a widespread chronic degenerative joint disease with an increasing global impact. The pathogenesis of OA involves complex interactions between genetic and environmental factors.
Xindie Zhou, Xinjian Ye, Jiapei Yao, Xiaolong Lin, Yiping Weng, Yong Huang, Yaojun Lu, JingJing Shang, Luming Nong   +8 more
semanticscholar   +1 more source

Identifying microRNA Biomarkers in Prostate Cancer: A Transcriptome-Wide Association Studies (TWAS) [PDF]

, 2020
Dulari K. Jayarathna, Miguel E. Rentería, Jyotsna Batra, Emilie Sauret, Samaneh Farashi, Neha S. Gandhi   +5 more
openalex