Transcriptome-wide association study twas

Results 31 to 40 of about 8,166 (222)

Transcriptome-wide association study identified candidate genes associated with gut microbiota

Gut Pathogens, 2021
Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities.
Chuyu Pan +12 more
doaj +1 more source

A large-scale transcriptome-wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine-mapping [PDF]

, 2022
Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases and are highly heritable. Although genome-wide association studies (GWAS) have identified thousands of loci containing trait-associated variants ...
A.L. Tapia +18 more
openalex +3 more sources

Transcriptome-wide association studies: recent advances in methods, applications and available databases

Communications Biology, 2023
Genome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those significant variants has been a great task.
Jialin Mai +4 more
doaj +1 more source

Dissecting the genetic heterogeneity of gastric cancerResearch in context

EBioMedicine, 2023
Summary: Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes.
Timo Hess +133 more
doaj +1 more source

A Transcriptome-Wide Association Study (TWAS) Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer.

Journal of the National Cancer Institute, 2020
BACKGROUND Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies (GWAS) in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown.
Jun Zhong +107 more
semanticscholar +1 more source

Population-Matched Transcriptome Prediction Increases TWAS Discovery and Replication Rate

iScience, 2020
Summary: Most genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) focus on European populations; however, these results cannot always be accurately applied to non-European populations due to genetic architecture ...
Elyse Geoffroy, Isabelle Gregga, Heather E. Wheeler +2 more
doaj +1 more source

MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

Nature Communications, 2023
Conventional transcriptome-wide association study (TWAS) approaches predict genetically regulated gene expression at the tissue level. Here, the authors develop a framework for cell-type-aware TWAS that predicts cell-type level expression from genotype ...
Xiaoyu Song +12 more
doaj +1 more source

Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia.

PLoS Genetics, 2021
Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene ...
Shizhen Tang +5 more
doaj +1 more source

Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits [PDF]

, 2021
Structural variations of the human brain are heritable and highly polygenic traits, with hundreds of associated genes identified in recent genome-wide association studies (GWAS).
Li, T. +11 more
core +2 more sources

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen +56 more
doaj +1 more source

biology
medicine
genetics

transcriptome
genome-wide association study
gene

gene expression
computational biology
computer science