Results 31 to 40 of about 6,140 (191)

TWAS revealed significant causal loci for milk production and its composition in Murrah buffaloes

Scientific Reports, 2023
Milk yield is the most complex trait in dairy animals, and mapping all causal variants even with smallest effect sizes has been difficult with the genome-wide association study (GWAS) sample sizes available in geographical regions with small livestock ...
Supriya Chhotaray, Vikas Vohra, Vishakha Uttam, Ameya Santhosh, Punjika Saxena, Rajesh Kumar Gahlyan, Gopal Gowane   +6 more
doaj   +1 more source

A Modification to Two-Stage Least Squares With Genetic Applications. [PDF]

Stat Med
ABSTRACT Two‐stage least squares (2SLS) is by default applied to infer a putative causal association between an exposure, such as a gene or a protein, with an outcome such as a complex disease or trait, in transcriptome‐ or proteome‐wide association studies (TWAS/PWAS).
Fang L, Pan W.
europepmc   +2 more sources

Multiple-Tissue Integrative Transcriptome-Wide Association Studies Discovered New Genes Associated With Amyotrophic Lateral Sclerosis

Frontiers in Genetics, 2020
Genome-wide association studies (GWAS) have identified multiple causal genes associated with amyotrophic lateral sclerosis (ALS); however, the genetic architecture of ALS remains completely unknown and a large number of causal genes have yet been ...
Lishun Xiao, Zhongshang Yuan, Siyi Jin, Ting Wang, Shuiping Huang, Shuiping Huang, Ping Zeng, Ping Zeng   +7 more
doaj   +1 more source

Identifying causal genes for migraine by integrating the proteome and transcriptome

The Journal of Headache and Pain, 2023
Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these variants contribute to the development of migraine.
Shuang-jie Li, Jing-jing Shi, Cheng-yuan Mao, Chan Zhang, Ya-fang Xu, Yu Fan, Zheng-wei Hu, Wen-kai Yu, Xiao-yan Hao, Meng-jie Li, Jia-di Li, Dong-rui Ma, Meng-nan Guo, Chun-yan Zuo, Yuan-yuan Liang, Yu-ming Xu, Jun Wu, Shi-lei Sun, Yong-gang Wang, Chang-he Shi   +19 more
doaj   +1 more source

Identifying celiac disease-related chemicals by transcriptome-wide association study and chemical-gene interaction analyses

Frontiers in Genetics, 2022
Celiac disease (CeD) is one of the most common intestinal inflammatory diseases, and its incidence and prevalence have increased over time. CeD affects multiple organs and systems in the body, and environmental factors play a key role in its complex ...
Mengnan Lu, Ruoyang Feng, Yuesheng Liu, Yujie Qin, Hongyang Deng, Yanfeng Xiao, Chunyan Yin   +6 more
doaj   +1 more source

Transcriptome-wide association study-derived genes as potential visceral adipose tissue-specific targets for type 2 diabetes

Diabetologia, 2023
Aims/hypothesis This study aimed to assess the causal relationship between visceral obesity and type 2 diabetes and subsequently to screen visceral adipose tissue (VAT)-specific targets for type 2 diabetes.
Haibo Tang, Jie Wang, Peizhi Deng, Yalan Li, Yaoquan Cao, B. Yi, Liyong Zhu, Shaihong Zhu, Yao Lu   +8 more
semanticscholar   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction

Frontiers in Genetics, 2021
BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen, Guanzhong Chen, Liwei Liu, Liwei Liu, Huanqiang Li, Zhubin Lun, Zhubin Lun, Ziling Mai, Ziling Mai, Wenguang Lai, Wenguang Lai, Enzhao Chen, Chunyun Zhou, Sijia Yu, Sijia Yu, Junqing Yang, Shiqun Chen, Jiyan Chen, Jiyan Chen, Jiyan Chen, Yong Liu, Yong Liu, Yong Liu   +22 more
doaj   +1 more source

A cross-tissue transcriptome association study identifies key genes in essential hypertension

Frontiers in Genetics, 2023
Genome-wide association study (GWAS) have identified over 1,000 loci associated with blood pressure. However, these loci only explain 6% of heritability. Transcriptome-wide association studies (TWAS) combine GWAS summary data with expression quantitative
Sihui Huang, Sihui Huang, Sihui Huang, Jie Wang, Jie Wang, Nannan Liu, Nannan Liu, Ping Li, Ping Li, Sha Wu, Sha Wu, Luming Qi, Luming Qi, Lina Xia, Lina Xia   +14 more
doaj   +1 more source

Transcriptome-wide association study reveals increased neuronal FLT3 expression is associated with Tourette’s syndrome

Communications Biology, 2022
Calwing Liao and Veikko Vuokila et al. report a transcriptome-wide association study (TWAS) of Tourette’s Syndrome. They find increased expression of FLT3 in the dorsolateral prefrontal cortex and the lymphoblastoid cell lines in patients with Tourette’s
Calwing Liao, Veikko Vuokila, Hélène Catoire, Fulya Akçimen, Jay P. Ross, Cynthia V. Bourassa, Patrick A. Dion, Inge A. Meijer, Guy A. Rouleau   +8 more
doaj   +1 more source

Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety

Frontiers in Genetics, 2021
Anxiety disorders are common mental disorders that often result in disability. Recently, large-scale genome-wide association studies (GWASs) have identified several novel risk variants and loci for anxiety disorders (or anxiety traits). Nevertheless, how
Xi Su, Xi Su, Wenqiang Li, Wenqiang Li, Luxian Lv, Luxian Lv, Xiaoyan Li, Jinfeng Yang, Jinfeng Yang, Xiong-Jian Luo, Xiong-Jian Luo, Xiong-Jian Luo, Xiong-Jian Luo, Jiewei Liu   +13 more
doaj   +1 more source