Results 61 to 70 of about 8,166 (222)

A Multi‐Ancestry TWAS in Alzheimer's Disease in African‐American, Hispanic/Latino and Non‐Hispanic White Populations [PDF]

Alzheimers Dement
Abstract Background Transcriptome‐wide association studies (TWAS) extend Genome‐wide association studies by integrating gene expression data to explore the functional consequences of non‐coding variants. This study employs a multi‐ancestry TWAS approach to identify AD‐associated genes across groups, leveraging data from the Multi‐Ancestry Genomics ...
Sun X, Mews M, Wheeler N, Benchek P, Reitz C, Naj A, Below J, Kunkle B, Griswold A, Bush W.   +9 more
europepmc   +2 more sources

Transcriptome-wide association study reveals candidate causal genes for lung cancer. [PDF]

, 2023
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large-scale expression quantitative trait loci (eQTL ...
Albanes, D, Aldrich, MC, Amos, CI, Andrew, A, Arnold, S, Bickeböller, H, Bojesen, SE, Bossé, Y, Brennan, P, Brunnstrom, H, Caporaso, N, Carreras-Torres, R, Chen, C, Christiani, DC, Field, JK, Gabriel, A, Gaudreault, N, Goodman, G, Grankvist, K, Houlston, R, Hung, RJ, Johansson, M, Johansson, M, Joubert, P, Kiemeney, LA, Lam, S, Landi, MT, Lazarus, P, Le Marchand, L, Li, Z, Liu, G, Manem, V, McKay, JD, Melander, O, Obeidat, M, Rennert, G, Risch, A, Rosenberg, SM, Schabath, MB, Shete, S, Song, Z, Stevens, VL, Tardon, A, Timens, W, Wichmann, H-E, Woll, P, Xia, J, Zienolddiny, S   +47 more
core   +1 more source

Heritability enrichment of immunoglobulin G N-glycosylation in specific tissues [PDF]

, 2021
Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain.
Cao, Weijie, Guo, Xiuhua, Han, Jingdong J, Hou, Haifeng, Lang, Minglin, Li, Xingang, Manshu, Song, Tan, Xuerui, Wang, Hao, Wang, Wei, Wang, Youxin, Zhu, Yahong   +11 more
core   +2 more sources

Identifying celiac disease-related chemicals by transcriptome-wide association study and chemical-gene interaction analyses

Frontiers in Genetics, 2022
Celiac disease (CeD) is one of the most common intestinal inflammatory diseases, and its incidence and prevalence have increased over time. CeD affects multiple organs and systems in the body, and environmental factors play a key role in its complex ...
Mengnan Lu, Ruoyang Feng, Yuesheng Liu, Yujie Qin, Hongyang Deng, Yanfeng Xiao, Chunyan Yin   +6 more
doaj   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction

Frontiers in Genetics, 2021
BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen, Guanzhong Chen, Liwei Liu, Liwei Liu, Huanqiang Li, Zhubin Lun, Zhubin Lun, Ziling Mai, Ziling Mai, Wenguang Lai, Wenguang Lai, Enzhao Chen, Chunyun Zhou, Sijia Yu, Sijia Yu, Junqing Yang, Shiqun Chen, Jiyan Chen, Jiyan Chen, Jiyan Chen, Yong Liu, Yong Liu, Yong Liu   +22 more
doaj   +1 more source

Mergeomics: a web server for identifying pathological pathways, networks, and key regulators via multidimensional data integration [PDF]

, 2016
Background: Human diseases are commonly the result of multidimensional changes at molecular, cellular, and systemic levels. Recent advances in genomic technologies have enabled an outpour of omics datasets that capture these changes.
Arneson, D., Bhattacharya, A., Mäkinen, V., Shu, L., Yang, X.   +4 more
core   +8 more sources

A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes [PDF]

, 2021
: Background: Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer’s disease (AD), but the genes responsible for these associations remain largely unknown.

core   +3 more sources

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Nature Communications, 2023
Alternative polyadenylation (APA) plays an essential role in brain development; however, current transcriptome-wide association studies (TWAS) largely overlook APA in nominating susceptibility genes.
Ya Cui, F. Arnold, Fanglue Peng, Dan Wang, J. Li, S. Michels, E. Wagner, A. L. La Spada, Wei Li   +8 more
semanticscholar   +1 more source

Transcriptome-wide association study reveals increased neuronal FLT3 expression is associated with Tourette’s syndrome

Communications Biology, 2022
Calwing Liao and Veikko Vuokila et al. report a transcriptome-wide association study (TWAS) of Tourette’s Syndrome. They find increased expression of FLT3 in the dorsolateral prefrontal cortex and the lymphoblastoid cell lines in patients with Tourette’s
Calwing Liao, Veikko Vuokila, Hélène Catoire, Fulya Akçimen, Jay P. Ross, Cynthia V. Bourassa, Patrick A. Dion, Inge A. Meijer, Guy A. Rouleau   +8 more
doaj   +1 more source

A cross-tissue transcriptome association study identifies key genes in essential hypertension

Frontiers in Genetics, 2023
Genome-wide association study (GWAS) have identified over 1,000 loci associated with blood pressure. However, these loci only explain 6% of heritability. Transcriptome-wide association studies (TWAS) combine GWAS summary data with expression quantitative
Sihui Huang, Sihui Huang, Sihui Huang, Jie Wang, Jie Wang, Nannan Liu, Nannan Liu, Ping Li, Ping Li, Sha Wu, Sha Wu, Luming Qi, Luming Qi, Lina Xia, Lina Xia   +14 more
doaj   +1 more source