Results 61 to 70 of about 6,140 (191)

A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine

The Journal of Headache and Pain
Background Migraine is a common neurological disorder with a strong genetic component. Despite the identification of over 100 loci associated with migraine susceptibility through genome-wide association studies (GWAS), the underlying causative genes and ...
Jianxiong Gui, Xiaoyue Yang, Chen Tan, Lingman Wang, Linxue Meng, Ziyao Han, Jiehua Liu, Li Jiang   +7 more
semanticscholar   +1 more source

Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study

Annals of the Rheumatic Diseases, 2022
Objective Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most loci remain unclear, hampering translation of these genetic discoveries.
X. Yin, Kwangwoo Kim, H. Suetsugu, S. Bang, L. Wen, Masaru Koido, Eunji Ha, Lu Liu, Y. Sakamoto, S. Jo, Ruixue Leng, N. Otomo, Young-Chang Kwon, Y. Sheng, N. Sugano, M. Y. Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, K. Ishigaki, W. Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, S. Shim, Xiao-dong Zheng, T. Miyamura, Y. Kang, Dongqing Ye, J. Nakamura, C. Suh, Yuanjia Tang, G. Motomura, Yong-Beom Park, Huihua Ding, T. Kuroda, J. Choe, Chengxu Li, H. Niiro, You-Hwa Park, Changbing Shen, T. Miyamoto, G. Ahn, Wenmin Fei, T. Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yongfei Wang, K. Amano, Dae Jin Park, Wanling Yang, Y. Tada, Y. Lau, K. Yamaji, Zhengwei Zhu, M. Shimizu, T. Atsumi, A. Suzuki, T. Sumida, Y. Okada, K. Matsuda, K. Matsuo, Y. Kochi, Kazuhiko Yamamoto, K. Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, N. Shen, S. Ikegawa, Hye-Soon Lee, Xuejun Zhang, C. Terao, Yong Cui, S. Bae   +80 more
semanticscholar   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identifies Candidate Genes Associated With Idiopathic Pulmonary Fibrosis

Frontiers in Genetics, 2020
Idiopathic pulmonary fibrosis (IPF) is a type of scarring lung disease characterized by a chronic, progressive, and irreversible decline in lung function. The genetic basis of IPF remains elusive.
Weiming Gong, Ping Guo, Lu Liu, Qingbo Guan, Qingbo Guan, Qingbo Guan, Zhongshang Yuan   +6 more
doaj   +1 more source

Integrative Transcriptome-Wide Analyses Uncover Novel Risk-Associated MicroRNAs in Hormone-Dependent Cancers

Frontiers in Genetics, 2021
BackgroundHormone-dependent cancers (HDC) are among the leading causes of death worldwide among both men and women. Some of the established risk factors of HDC include unhealthy lifestyles, environmental factors, and genetic influences.
Dulari K. Jayarathna, Dulari K. Jayarathna, Miguel E. Rentería, Miguel E. Rentería, Adil Malik, Adil Malik, Emilie Sauret, Jyotsna Batra, Jyotsna Batra, Neha S. Gandhi, Neha S. Gandhi   +10 more
doaj   +1 more source

Gaining new insights into the etiology of ulcerative colitis through a cross-tissue transcriptome-wide association study

Frontiers in Genetics
Background Genome-wide association studies (GWASs) have identified 38 loci associated with ulcerative colitis (UC) susceptibility, but the risk genes and their biological mechanisms remained to be comprehensively elucidated. Methods Multi-marker analysis
Shijie Ren, Chaodi Sun, Wenjing Zhai, Wenli Wei, Jianping Liu   +4 more
semanticscholar   +1 more source

Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations

eLife, 2022
Genome-wide association studies (GWASs) for bone mineral density (BMD) in humans have identified over 1100 associations to date. However, identifying causal genes implicated by such studies has been challenging.
B. Al-Barghouthi, Will T. Rosenow, Kangping Du, J. Heo, R. Maynard, L. Mesner, G. Calabrese, Aaron Nakasone, Bhavya Senwar, L. Gerstenfeld, James Larner, Virginia Ferguson, C. Ackert-Bicknell, E. Morgan, D. Brautigan, C. Farber   +15 more
semanticscholar   +1 more source

Marker Metabolite‐Based Multi‐Omics Analysis Identifies New Loci Controlling Thousand Seed Weight in Brassica Napus

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Marker metabolite‐based multi‐omics (genome, transcriptome, and metabolome) analysis is conducted firstly to unravel the genetic basis of thousand seed weight (TSW) in Brassica napus. The released metabolite‐QTL‐gene network represents a valuable genetic resource, and the newly validated BnaTGA6 is a promising target for the improvement of TSW in ...
Long Li, Zhitao Tian, Xiaowei Wu, Zengdong Tan, Xu Han, Yuyan Xiang, Jie Chen, Hu Zhao, Wei Chen, Liang Guo, Xuan Yao   +10 more
wiley   +1 more source

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia

Alzheimer’s Research & Therapy
Background Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome.
Shuyi Guo, Jingjing Yang
doaj   +1 more source

Transcriptome-wide association study identifies new susceptibility genes for degenerative cervical spondylosis

Bone & Joint Research, 2023
AimsDegenerative cervical spondylosis (DCS) is a common musculoskeletal disease that encompasses a wide range of progressive degenerative changes and affects all components of the cervical spine.
Jiawen Xu, Haibo Si, Yi Zeng, Yuangang Wu, Shaoyun Zhang, Yuan Liu, Mingyang Li, Bin Shen   +7 more
doaj   +1 more source

Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer’s disease

Translational Psychiatry
The etiopathogenesis of late-onset Alzheimer’s disease (AD) is increasingly recognized as the result of the combination of the aging process, toxic proteins, brain dysmetabolism, and genetic risks.
Jing Tian, Kun Jia, Tienju Wang, Lan Guo, Zhenyu Xuan, Elias K. Michaelis, R. Swerdlow, Heng Du   +7 more
semanticscholar   +1 more source