Results 71 to 80 of about 6,140 (191)

Incorporating genome-wide and transcriptome-wide association studies to identify genetic elements of longissimus dorsi muscle in Huaxi cattle

Frontiers in Genetics, 2023
Locating the genetic variation of important livestock and poultry economic traits is essential for genetic improvement in breeding programs. Identifying the candidate genes for the productive ability of Huaxi cattle was one crucial element for practical ...
Mang Liang, Bingxing An, Tianyu Deng, Lili Du, Keanning Li, Sheng Cao, Yueying Du, Lingyang Xu, Lupei Zhang, Xue Gao, Yang Cao, Yuming Zhao, Junya Li, Huijiang Gao   +13 more
doaj   +1 more source

Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract

Frontiers in Ophthalmology
Introduction Cataract is the leading cause of blindness among the elderly worldwide. Twin and family studies support an important role for genetic factors in cataract susceptibility with heritability estimates up to 58%.
H. Choquet, Matthieu Duot, Victor A. Herrera, Sanjaya K. Shrestha, Travis J Meyers, Thomas J. Hoffmann, P. Sangani, S. Lachke   +7 more
semanticscholar   +1 more source

A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes

Genome Medicine, 2021
Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer’s disease (AD), but the genes responsible for these associations remain largely unknown.
Yanfa Sun, Jingjing Zhu, Dan Zhou, S. Canchi, Chong Wu, N. Cox, R. Rissman, E. Gamazon, Lang Wu   +8 more
semanticscholar   +1 more source

Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults.

PLoS Genetics, 2021
As a type of relatively new methodology, the transcriptome-wide association study (TWAS) has gained interest due to capacity for gene-level association testing.
Binglan Li, Yogasudha Veturi, Anurag Verma, Yuki Bradford, Eric S Daar, Roy M Gulick, Sharon A Riddler, Gregory K Robbins, Jeffrey L Lennox, David W Haas, Marylyn D Ritchie   +10 more
doaj   +1 more source

TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies [PDF]

, 2022
Mingming Lu, Yadong Zhang, Fengchun Yang, Jialin Mai, Qianwen Gao, Xiaowei Xu, Hongyu Kang, Li Hou, Yunfei Shang, Qiheng Qain, Jie Liu, Meiye Jiang, Hao Zhang, Congfan Bu, Jinyue Wang, Zhewen Zhang, Zaichao Zhang, Jingyao Zeng, Jiao Li, Jingfa Xiao   +19 more
openalex   +1 more source

A Self‐Assembling Peptide with Nanoparticle‐to‐Fibril Transformation Exhibits Multimodal Antimicrobial Activity through Membrane Disruption and Quorum‐Sensing Inhibition

Small, Volume 21, Issue 44, November 6, 2025.
A self‐assembling peptide that transforms from nanoparticles into bacterial‐entrapping nanofibrils and targets multi‐drug‐resistant pathogens through a dual mechanism. It disrupts bacterial membranes and strongly inhibits the quorum‐sensing system, a crucial factor in biofilm formation and virulence.
James Mwangi, Demeke Asmamaw, Min Yang, Dawit Adisu Tadese, Brenda B. Michira, Yi Wang, Sheng‐wen Zhou, Gan Wang, Ziyi Wang, Qiu‐Min Lu, Ren Lai   +10 more
wiley   +1 more source

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for frailty

Frontiers in Genetics
Background: Although genome-wide association studies (GWAS) have identified 14 loci associated with frailty index (FI) susceptibility, the underlying causative genes and biological mechanisms remain elusive.
Daoyi Lin, Shuyan Wu, Wangyu Li, Peng Ye, Xuan Pan, Ting Zheng, Fei Gao   +6 more
semanticscholar   +1 more source

GmSop20 Functions as a Key Coordinator of the Oil‐To‐Protein Ratio in Soybean Seeds

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study investigates the seed oil‐to‐protein ratio as a comprehensive quality metric and identifies GmSop20 as a crucial regulatory gene through forward genetics methodologies. By integrating GmSop20 with superior haplotypes and using gene editing/overexpression, new strategies are provided for precisely tuning the seed oil‐to‐protein ratio, thereby
Haowei Zheng, Xinkang Feng, Longlong Wang, Wentao Shao, Shiyu Guo, Duo Zhao, Jiajia Li, Long Yan, Long Miao, Bincheng Sun, Huihui Gao, Hongmei Qiu, Yu Hu, Linlin Kong, Robert M. Stupar, Ying‐hui Li, Li‐juan Qiu, Xiaobo Wang   +17 more
wiley   +1 more source

Methyl-TWAS: A powerful method forin silicotranscriptome-wide association studies (TWAS) using long-range DNA methylation [PDF]

, 2023
Soyeon Kim, Yidi Qin, Hyun Jung Park, Molin Yue, Zhongli Xu, Erick Forno, Wei Chen, Juan C. Celedón   +7 more
openalex   +1 more source

Transcriptome-Wide Association Study Reveals Potentially Candidate Genes Responsible for Milk Production Traits in Buffalo

International Journal of Molecular Sciences
Identifying key causal genes is critical for unraveling the genetic basis of complex economic traits, yet it remains a formidable challenge. The advent of large-scale sequencing data and computational algorithms, such as transcriptome-wide association ...
Kelong Wei, Ying Lu, Xiaoya Ma, Anqian Duan, Xing-rong Lu, H. Abdel-Shafy, T. Deng   +6 more
semanticscholar   +1 more source