Results 81 to 90 of about 6,140 (191)

GRPa‐PRS: A risk stratification method to identify genetically‐regulated pathways in polygenic diseases

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Polygenic risk score (PRS) assesses genetic risk for diseases, yet some high‐risk individuals avoid illness while low‐risk individuals develop it. We hypothesize that unknown counterfactors may reverse PRS predictions, offering insights into disease mechanisms and interventions.
Xiaoyang Li, Brisa S. Fernandes, Andi Liu, Jingchun Chen, Xiangning Chen, Zhongming Zhao, Yulin Dai   +6 more
wiley   +1 more source

Transcriptome-wide association study identifies new susceptibility genes and pathways for depression

Translational Psychiatry, 2021
Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechanisms and ...
Xiaoyan Li, Xi Su, Jiewei Liu, Huijuan Li, Ming Li, the 23andMe Research Team, Wenqiang Li, Xiong-Jian Luo   +7 more
doaj   +1 more source

Transcriptome-Wide Association Study Reveals New Molecular Interactions Associated with Melanoma Pathogenesis

Cancers
Simple Summary The journey of discovering melanoma—the most dangerous type of skin cancer—biomarkers is never-ending. Under that assumption, this study attempts to partially fill a gap in that journey by identifying melanoma-related biomarkers.
Mohamed N. Saad, Mohamed Hamed
semanticscholar   +1 more source

RAB19, SERPINB9P1, and Pancreatitis in Patients Taking Azathioprine in Routine Clinical Practice: Genome and Transcriptome‐Wide Association Studies

Clinical Pharmacology &Therapeutics, Volume 118, Issue 4, Page 946-953, October 2025.
Azathioprine is used to treat several inflammatory and autoimmune diseases. However, its use is limited by serious adverse events, including acute pancreatitis. Prior studies have found an association between the HLA region and thiopurine‐induced acute pancreatitis (TIAP); however, in clinical practice, many patients with pancreatitis do not meet this ...
Shailja C. Shah, Tyler S. Reese, Laura L. Daniel, Jacy Zanussi, Alyson L. Dickson, Puran Nepal, Ran Tao, Tyne Miller‐Fleming, Peter Straub, Jennifer Maizel, Adriana M. Hung, Wei‐Qi Wei, Elizabeth J. Phillips, Nancy J. Cox, C. Michael Stein, QiPing Feng, Cecilia P. Chung   +16 more
wiley   +1 more source

Assessing Evolutionary Divergence in Genome‐Wide MADS‐Box Genes and Expression Profiles Between Toona ciliata and Toona sinensis

Ecology and Evolution, Volume 15, Issue 10, October 2025.
Collinearity analysis of MADS‐box genes in T. ciliata var. ciliata, T. sinensis, and A. thaliana. ABSTRACT Toona ciliata and Toona sinensis, two economically important timber species in China, exhibit interspecific variation in floral traits that are related to mating systems.
Xiao‐Han Liu, Yu Xiao, Yan‐Wen Lv, Zi‐Yun Wang, Chao Wu, Hui Xie, Xin‐Sheng Hu   +6 more
wiley   +1 more source

Editorial: Statistical methods for genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) and their applications [PDF]

, 2023
Mengting Shao, Zilong Zhang, Huiyan Sun, Jingni He, Juexin Wang, Qingrun Zhang, Chen Cao   +6 more
openalex   +1 more source

Synovial transcriptome-wide association study implicates novel genes underlying rheumatoid arthritis risk.

Rheumatology
OBJECTIVES This study aimed to address the lack of gene expression regulation data in synovial tissues and to identify conditionally independent genes associated with rheumatoid arthritis (RA) in the synovium, a primary target tissue for RA.
Shouye Hu, Feng Jiang, Huimiao Song, Yakang Wang, Wen Tian, Hao Wu, S. Yao, Chang-Yi He, Hui-Wu Gao, Tie-Lin Yang, Zhi Yang, Yan Guo   +11 more
semanticscholar   +1 more source

A transcriptome-wide association study identified susceptibility genes for hepatocellular carcinoma in East Asia

Gastroenterology Report
Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is prevalent in East Asia. Although genome-wide association studies (GWASs) of HCC have identified 23 risk regions, the susceptibility genes underlying these ...
Jingjing Zhang, Qingrong Zhang, Wenyan Hu, Yuxuan Liang, Deke Jiang, Haitao Chen   +5 more
semanticscholar   +1 more source

scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework

Cell Genomics
Summary: Transcriptome-wide association studies (TWASs) help identify disease-causing genes but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type-specific expression data.
Yichao Zhou, Temidayo Adeluwa, Lisha Zhu, Sofia Salazar-Magaña, Sarah Sumner, Hyunki Kim, Saideep Gona, Festus Nyasimi, Rohit Kulkarni, Joseph E. Powell, Ravi Madduri, Boxiang Liu, Mengjie Chen, Hae Kyung Im   +13 more
doaj   +1 more source

Multi-omic characterization of air pollution effects: Applications of AirSigOmniTWP Hub

Ecotoxicology and Environmental Safety
Air pollution, particularly fine particulate matter and gaseous pollutants including NO2 and NOx, presents significant public health challenges. While the harmful effects of these pollutants are well-documented, the molecular mechanisms underlying their ...
Wei Liu, Tong Liu, Xinxin Si, Jiaxing Liang, Xia Yan, Juexin Zhang, Bing Pang, Wenmin Luo, Junhong Liu, Huazhe Yang, Peng Shi   +10 more
doaj   +1 more source