Results 31 to 40 of about 654,399 (276)

Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model

Drug Design, Development and Therapy, 2021
Chunyan Wang,1,2,* Zhengyun Chen,1,* Xianlei Zhao,2,* Cuicui Lin,2 Shenghui Hong,3 Yuhan Lou,2 Xiaomeng Shi,1 Mengdan Zhao,1 Xiaohang Yang,1,2 Min-Xin Guan,2 Yongmei Xi1,2 1The Women’s Hospital, Zhejiang University School of Medicine ...
Wang C, Chen Z, Zhao X, Lin C, Hong S, Lou Y, Shi X, Zhao M, Yang X, Guan MX, Xi Y   +10 more
doaj  

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum [PDF]

, 2008
As nonreplicating tubercle bacilli are tolerant to the cidal action of antibiotics and resistant to multiple stresses, identification of this persister-like population of tubercle bacilli in sputum presents exciting and tractable new opportunities to ...
Alvarez, Anna L Sherratt, Bacon, Beste, Betts, Canetti, Claire Senner, Cole, Connolly, Conway, Daniel, Daugelat, Desjardin, Dhar, Dubnau, Eisen, Fenhalls, Fleischmann, Garnier, Garton, Gomez, Gurdyal S Besra, Jason Hinds, Kalscheuer, Karakousis, Kendall, Kolter, Kumar, Kumar Rajakumar, Larsen, Levin, Mangan, Manganelli, McKinney, Michael R Barer, Mitchison, Mitchison, Monahan, Mukamolova, Munoz-Elias, Murphy, Muttucumaru, Nakagawa, Natalie J Garton, Neyrolles, Olivier Neyrolles, Paramasivan, Park, Philip D Butcher, Rachman, Rajakumar, Rebecca J Smith, Reed, Richard A Adegbola, Rohde, Schnappinger, Shi, Siegele, Simon J Waddell, Sirakova, Smeulders, Sommers, Stewart, Su-Min Lee, Talaat, Talaat, Timm, Van der Geize, Voskuil, Waddell, Waddell, Waddell, Waltermann, Wayne, Wayne, Weichart, Wilkinson, Young   +77 more
core   +4 more sources

Single cell transcriptome analysis using next generation sequencing. [PDF]

, 2010
The heterogeneity of tissues, especially in cancer research, is a central issue in transcriptome analysis. In recent years, research has primarily focused on the development of methods for single cell analysis. Single cell analysis aims at gaining (novel)
Blattner, M.
core   +1 more source

Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia. [PDF]

, 2016
Autism (AUT), schizophrenia (SCZ) and bipolar disorder (BPD) are three highly heritable neuropsychiatric conditions. Clinical similarities and genetic overlap between the three disorders have been reported; however, the causes and the downstream effects ...
Arking, DE, Ellis, SE, Panitch, R, West, AB   +3 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Differential Effects of the Hormonal and Copper Intrauterine Device on the Endometrial Transcriptome. [PDF]

, 2020
The contraceptive effectiveness of intrauterine devices (IUDs) has been attributed in part to a foreign body reaction in the endometrium. We performed this study to better understand mechanisms of action of contraceptives of by studying their effects on ...
Averbach, Sarah, Giudice, Linda C, Houshdaran, Sahar, Seidman, Dominika, Smith-McCune, Karen, Takeda, Margaret, Thomas, Reuben   +6 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Universal relationship in gene-expression changes for cells in steady-growth state

, 2014
Cells adapt to different conditions by altering a vast number of components, which is measurable using transcriptome analysis. Given that a cell undergoing steady growth is constrained to sustain each of its internal components, the abundance of all the ...
Furusawa, Chikara, Kaneko, Kunihiko, Yomo, Tetsuya   +2 more
core   +2 more sources

Transcript profiling for early stages during embryo development in Scots pine [PDF]

, 2016
Background: Characterization of the expression and function of genes regulating embryo development in conifers is interesting from an evolutionary point of view.
Abrahamsson, Malin, Canovas, Francisco, Craven-Bartle, Blanca, Merino, Irene, Sterck, Lieven, von Arnold, Sara   +5 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source