Results 71 to 80 of about 654,399 (276)

Integrating QTL mapping and transcriptome analysis to provide molecular insights into gynophore-pod strength in cultivated peanut (Arachis hypogaea L.)

Frontiers in Plant Science
IntroductionGynophore-pod strength is one of important mechanical properties that affect mechanized harvesting quality in peanut. Yet its molecular regulation remains elusive.MethodsWe measured gynophore-pod strength across three environments using a ...
Wen Chu, Xiaofeng Zhu, Tao Jiang, Song Wang, Wanli Ni   +4 more
doaj   +1 more source

Exploration of alternative splicing events in ten different grapevine cultivars [PDF]

, 2015
Background: The complex dynamics of gene regulation in plants are still far from being fully understood. Among many factors involved, alternative splicing (AS) in particular is one of the least well documented.
Asquini, Elisa, Cestaro, Alessandro, Coller, Emanuela, Potenza, Emilio, Racchi, Milvia Luisa, Sterck, Lieven, Tosatto, Silvio CE, Van de Peer, Yves, Velasco, Riccardo   +8 more
core   +7 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Transcriptome Analysis Elucidates the Potential Key Genes Involved in Rib Development in bmp6-Deficient Silver Carp (Hypophthalmichthys molitrix)

Animals
Bone morphogenetic protein 6 (BMP-6) is a constituent of the TGF-β superfamily, known for its ability to stimulate bone and cartilage formation. The investigation of bmp6’s involvement in the formation of intermuscular bones in fish has garnered ...
Xiaohui Li, Chunyan Zhang, Cui Feng, Zewen Zhang, Nannan Feng, Hang Sha, Xiangzhong Luo, Guiwei Zou, Hongwei Liang   +8 more
doaj   +1 more source

OmicSDK-Transcriptomics: A Web Platform for Transcriptomics Data Analysis

, 2023
Omics sciences, especially transcriptomics, have grown exponentially since the first human genome was sequenced in 2003. Different tools have been developed in the past years for the analysis of this kind of data, but many of them require specific programming knowledge to be used.
Sucre, Aurora, Martinez, Maria, Garin-Muga, Alba   +2 more
openaire   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

New Insight into the Related Candidate Genes and Molecular Regulatory Mechanisms of Waterlogging Tolerance in Tree Peony Paeonia ostii

Plants
Research on the waterlogging tolerance mechanisms of Paeonia ostii helps us to further understand these mechanisms in the root system and enhance its root bark and oil yields in southern China.
Minghui Zhou, Xiang Liu, Jiayan Zhao, Feng Jiang, Weitao Li, Xu Yan, Yonghong Hu, Junhui Yuan   +7 more
doaj   +1 more source

PATTERNA: transcriptome-wide search for functional RNA elements via structural data signatures. [PDF]

, 2018
Establishing a link between RNA structure and function remains a great challenge in RNA biology. The emergence of high-throughput structure profiling experiments is revolutionizing our ability to decipher structure, yet principled approaches for ...
Aviran, Sharon, Ledda, Mirko
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Molecular Regulation of Photosynthetic Carbon Assimilation in Oat Leaves Under Drought Stress

Plants
Common oat (Avena sativa L.) is one of the important minor grain crops in China, and drought stress severely affects its yield and quality. To investigate the drought resistance characteristics of oat seedlings, this study used Baiyan 2, an oat cultivar ...
Yiqun Xu, Liling Jiang, Jia Gao, Wei Zhang, Meijun Zhang, Changlai Liu, Juqing Jia   +6 more
doaj   +1 more source