Results 101 to 110 of about 398,969 (379)
Journal of Translational Medicine, 2018 Background Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vaccines within a few weeks from ...
Katja Sonntag +11 more
doaj +1 more source
A comparative analysis of single-cell transcriptomic technologies in plants and animals
Current Plant Biology, 2023 The development of sequencing methods has resulted in the investigation of many unexplored research areas. Among the different sequencing methods, single-cell transcriptomics is versatile and has completely changed the researchers' perception of ...
Vamsidhar Reddy Netla +5 more
doaj +1 more source
Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]
, 2014 BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A +4 more
core +2 more sources
Robust decomposition of cell type mixtures in spatial transcriptomics
Nature Biotechnology, 2020 A limitation of spatial transcriptomics technologies is that individual measurements may contain contributions from multiple cells, hindering the discovery of cell-type-specific spatial patterns of localization and expression.
Dylan M. Cable +6 more
semanticscholar +1 more source
Spatial Transcriptomics: Emerging Technologies in Tissue Gene Expression Profiling
Analytical Chemistry, 2023 In this Perspective, we discuss the current status and advances in spatial transcriptomics technologies, which allow high-resolution mapping of gene expression in intact cell and tissue samples.
Agustín Robles-Remacho +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley +1 more source
Spatial Transcriptomic Technologies
Cells, 2023 Spatial transcriptomic technologies enable measurement of expression levels of genes systematically throughout tissue space, deepening our understanding of cellular organizations and interactions within tissues as well as illuminating biological insights in neuroscience, developmental biology and a range of diseases, including cancer.
Tsai-Ying Chen +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley +1 more source
Fishing Into the MicroRNA Transcriptome [PDF]
Frontiers in Genetics, 2018 In the last decade, several studies have been focused on revealing the microRNA (miRNA) repertoire and determining their functions in farm animals such as poultry, pigs, cattle, and fish. These small non-protein coding RNA molecules (18-25 nucleotides) are capable of controlling gene expression by binding to messenger RNA (mRNA) targets, thus ...
Herkenhoff, Marcos E. +6 more
openaire +5 more sources
Frontiers in Cellular and Infection Microbiology, 2019 Small non-coding RNAs play a significant role in bacterial adaptation to changing environmental conditions. We investigated the dynamics of expression of MTS1338, a small non-coding RNA of Mycobacterium tuberculosis, in the mouse model in vivo ...
Elena G. Salina +10 more
doaj +1 more source