Results 31 to 40 of about 398,969 (379)

Methylocystis sp. Strain SC2 Acclimatizes to Increasing NH4+ Levels by a Precise Rebalancing of Enzymes and Osmolyte Composition

open access: yesmSystems, 2022
A high NH4+ load is known to inhibit bacterial methane oxidation. This is due to a competition between CH4 and NH3 for the active site of particulate methane monooxygenase (pMMO), which converts CH4 to CH3OH.
Kangli Guo   +4 more
doaj   +1 more source

Metatranscriptomics reveals a differential temperature effect on the structural and functional organization of the anaerobic food web in rice field soil

open access: yesMicrobiome, 2018
Background The expected increase in global surface temperature due to climate change may have a tremendous effect on the structure and function of the anaerobic food web in flooded rice field soil.
Jingjing Peng   +4 more
doaj   +1 more source

Modeling population size independent tissue epigenomes by ChIL‐seq with single thin sections

open access: yesMolecular Systems Biology, 2021
Recent advances in genome‐wide technologies have enabled analyses using small cell numbers of even single cells. However, obtaining tissue epigenomes with cell‐type resolution from large organs and tissues still remains challenging, especially when the ...
Kazumitsu Maehara   +11 more
doaj   +1 more source

Photo-isolation chemistry for high-resolution and deep spatial transcriptome with mouse tissue sections

open access: yesSTAR Protocols, 2022
Summary: Photo-isolation chemistry (PIC) enables isolation of transcriptome information from locally defined areas by photo-irradiation. Here, we present an optimized PIC protocol for formalin-fixed frozen and paraffin mouse sections and fresh-frozen ...
Mizuki Honda   +6 more
doaj   +1 more source

Transcriptomics technologies

open access: yesPLOS Computational Biology, 2017
© 2017 Lowe et al. Transcriptomics technologies are the techniques used to study an organism’s transcriptome, the sum of all of its RNA transcripts. The information content of an organism is recorded in the DNA of its genome and expressed through transcription.
Rohan Lowe   +4 more
openaire   +6 more sources

Oomycete transcriptomics database: A resource for oomycete transcriptomes [PDF]

open access: yesBMC Genomics, 2012
Oomycete pathogens have attracted significant attention in recent years due to their economic impact. With improving sequencing technologies, large amounts of oomycete transcriptomics data are now available which have great biological utility. A known bottleneck with next generation sequencing data however lies with their analysis, interpretation ...
Brett M. Tyler   +3 more
openaire   +4 more sources

Quantitative RNA-seq Analysis Unveils Osmotic and Thermal Adaptation Mechanisms Relevant for Ectoine Production in Chromohalobacter salexigens [PDF]

open access: yes, 2018
Quantitative RNA sequencing (RNA-seq) and the complementary phenotypic assays were implemented to investigate the transcriptional responses of Chromohalobacter salexigens to osmotic and heat stress.
Carmen Vargas   +6 more
core   +2 more sources

Defining the nociceptor transcriptome [PDF]

open access: yesFrontiers in Molecular Neuroscience, 2014
Unbiased "omics" techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets.
Thakur, Matthew   +9 more
openaire   +5 more sources

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

open access: yes, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna   +11 more
core   +2 more sources

An introduction to spatial transcriptomics for biomedical research

open access: yesGenome Medicine, 2022
Single-cell transcriptomics (scRNA-seq) has become essential for biomedical research over the past decade, particularly in developmental biology, cancer, immunology, and neuroscience.
Cameron G. Williams   +4 more
semanticscholar   +1 more source

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