Results 31 to 40 of about 380,258 (247)

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

Nature Cardiovascular Research, 2022
Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell transcriptomics have revolutionized our understanding of cell composition and associated gene expression.
Andrew L. Koenig, I. Shchukina, Junedh M. Amrute, P. Andhey, Konstantin Zaitsev, Lulu Lai, G. Bajpai, Andrea L Bredemeyer, Gabriella Smith, Cameran Jones, Emily Terrebonne, S. Rentschler, M. Artyomov, Kory J. Lavine   +13 more
semanticscholar   +1 more source

Making open data work for plant scientists [PDF]

, 2013
Despite the clear demand for open data sharing, its implementation within plant science is still limited. This is, at least in part, because open data-sharing raises several unanswered questions and challenges to current research practices.
Alsheikh-Ali, Ball, Barrett, Bastow, Baxter, Brazma, Breeze, Brenchley, Charis Cook, Fernie, Hickman, International Arabidopsis Informatics Consortium, International Arabidopsis Informatics Consortium, Jonathan Moore, Leonelli, Nicholas Smirnoff, Rogers, Royal Society, Rustici, Ruth Bastow, Sabina Leonelli, The International Barley Genome Sequencing Consortium, Windram, Winter, Zimmermann   +24 more
core   +1 more source

Metatranscriptomics reveals a differential temperature effect on the structural and functional organization of the anaerobic food web in rice field soil

Microbiome, 2018
Background The expected increase in global surface temperature due to climate change may have a tremendous effect on the structure and function of the anaerobic food web in flooded rice field soil.
Jingjing Peng, Carl-Eric Wegner, Qicheng Bei, Pengfei Liu, Werner Liesack   +4 more
doaj   +1 more source

Cost effective, experimentally robust differential-expression analysis for human/mammalian, pathogen and dual-species transcriptomics. [PDF]

, 2020
As sequencing read length has increased, researchers have quickly adopted longer reads for their experiments. Here, we examine 14 pathogen or host-pathogen differential gene expression data sets to assess whether using longer reads is warranted.
Bruno, Vincent M, Chung, Matthew, Dunning Hotopp, Julie C, Filler, Scott G, Fraser, Claire M, Mahurkar, Anup, Mattick, John, McCracken, Carrie, Rasko, David A, Shetty, Amol C   +9 more
core   +2 more sources

Maternal recognition of pregnancy in the horse : are MicroRNAs the secret messengers? [PDF]

, 2020
The signal for maternal recognition of pregnancy (MRP) has still not been identified in the horse. High-throughput molecular biology at the embryo-maternal interface has substantially contributed to the knowledge on pathways affected during MRP, but an ...
Deforce, Dieter, Gansemans, Yannick, Gerits, Ilse, Govaere, Jan, Peelman, Luc, Roels, Kim, Smits, Katrien, Tilleman, Laurentijn, Van de Velde, Margot, Van Nieuwerburgh, Filip, Van Soom, Ann, Ververs, Cyrillus   +11 more
core   +2 more sources

Modeling population size independent tissue epigenomes by ChIL‐seq with single thin sections

Molecular Systems Biology, 2021
Recent advances in genome‐wide technologies have enabled analyses using small cell numbers of even single cells. However, obtaining tissue epigenomes with cell‐type resolution from large organs and tissues still remains challenging, especially when the ...
Kazumitsu Maehara, Kosuke Tomimatsu, Akihito Harada, Kaori Tanaka, Shoko Sato, Megumi Fukuoka, Seiji Okada, Tetsuya Handa, Hitoshi Kurumizaka, Noriko Saitoh, Hiroshi Kimura, Yasuyuki Ohkawa   +11 more
doaj   +1 more source

Methylocystis sp. Strain SC2 Acclimatizes to Increasing NH4+ Levels by a Precise Rebalancing of Enzymes and Osmolyte Composition

mSystems, 2022
A high NH4+ load is known to inhibit bacterial methane oxidation. This is due to a competition between CH4 and NH3 for the active site of particulate methane monooxygenase (pMMO), which converts CH4 to CH3OH.
Kangli Guo, Anna Hakobyan, Timo Glatter, Nicole Paczia, Werner Liesack   +4 more
doaj   +1 more source

Spatially Informed Cell Type Deconvolution for Spatial Transcriptomics

Nature Biotechnology, 2022
Many spatially resolved transcriptomic technologies do not have single-cell resolution but measure the average gene expression for each spot from a mixture of cells of potentially heterogeneous cell types.
Ying Ma, Xiang Zhou
semanticscholar   +1 more source

Complex Systems Science: Dreams of Universality, Reality of Interdisciplinarity [PDF]

, 2012
Using a large database (~ 215 000 records) of relevant articles, we empirically study the "complex systems" field and its claims to find universal principles applying to systems in general. The study of references shared by the papers allows us to obtain
Bastian M., Börner K., Fox–Keller E., Galison P., Kessler M.M., Leydesdorff L., Nicolis G., Press W.H., Venturini T., Von Bertalanffy L.   +9 more
core   +4 more sources

The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target

Viruses, 2023
The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect the human population against severe forms of COVID-19.
Teresa Santos-Mendoza
doaj   +1 more source