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PLOS Computational Biology, 2017 © 2017 Lowe et al. Transcriptomics technologies are the techniques used to study an organism’s transcriptome, the sum of all of its RNA transcripts. The information content of an organism is recorded in the DNA of its genome and expressed through transcription.
Rohan Lowe +4 more
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Microbiome, 2018 Background The expected increase in global surface temperature due to climate change may have a tremendous effect on the structure and function of the anaerobic food web in flooded rice field soil.
Jingjing Peng +4 more
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And Now, Transcriptomics [PDF]
Neuron, 2002 In this issue of Neuron, report different patterns of 5-HT2C pre-mRNA editing in suicide victims, as compared to controls. Treatment of mice with fluoxetine alters the pattern of 5-HT2C transcript editing in the direction opposite that observed for suicide victims.
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The transcriptome of metamorphosing flatfish [PDF]
BMC Genomics, 2016 Flatfish metamorphosis denotes the extraordinary transformation of a symmetric pelagic larva into an asymmetric benthic juvenile. Metamorphosis in vertebrates is driven by thyroid hormones (THs), but how they orchestrate the cellular, morphological and functional modifications associated with maturation to juvenile/adult states in flatfish is an enigma.
Melody S. Clark +10 more
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Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure
Nature Cardiovascular Research, 2022 Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell transcriptomics have revolutionized our understanding of cell composition and associated gene expression.
Andrew L. Koenig +13 more
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Defining the nociceptor transcriptome [PDF]
Frontiers in Molecular Neuroscience, 2014 Unbiased "omics" techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets.
Thakur, Matthew +9 more
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Modeling population size independent tissue epigenomes by ChIL‐seq with single thin sections
Molecular Systems Biology, 2021 Recent advances in genome‐wide technologies have enabled analyses using small cell numbers of even single cells. However, obtaining tissue epigenomes with cell‐type resolution from large organs and tissues still remains challenging, especially when the ...
Kazumitsu Maehara +11 more
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mSystems, 2022 A high NH4+ load is known to inhibit bacterial methane oxidation. This is due to a competition between CH4 and NH3 for the active site of particulate methane monooxygenase (pMMO), which converts CH4 to CH3OH.
Kangli Guo +4 more
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Evolution of the unspliced transcriptome [PDF]
BMC Evolutionary Biology, 2015 Despite their abundance, unspliced EST data have received little attention as a source of information on non-coding RNAs. Very little is know, therefore, about the genomic distribution of unspliced non-coding transcripts and their relationship with the much better studied regularly spliced products. In particular, their evolution has remained virtually
Engelhardt, Jan, Stadler, Peter F.
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The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target
Viruses, 2023 The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect the human population against severe forms of COVID-19.
Teresa Santos-Mendoza
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