Results 41 to 50 of about 398,969 (379)
The transcriptome of metamorphosing flatfish [PDF]
BMC Genomics, 2016 Flatfish metamorphosis denotes the extraordinary transformation of a symmetric pelagic larva into an asymmetric benthic juvenile. Metamorphosis in vertebrates is driven by thyroid hormones (THs), but how they orchestrate the cellular, morphological and functional modifications associated with maturation to juvenile/adult states in flatfish is an enigma.
Melody S. Clark +10 more
openaire +5 more sources
Museum of spatial transcriptomics [PDF]
Nature Methods, 2020 AbstractThe function of many biological systems, such as embryos, liver lobules, intestinal villi, and tumors depends on the spatial organization of their cells. In the past decade high-throughput technologies have been developed to quantify gene expression in space, and computational methods have been developed that leverage spatial gene expression ...
Lambda Moses, L. Pachter
semanticscholar +7 more sources
The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target
Viruses, 2023 The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect the human population against severe forms of COVID-19.
Teresa Santos-Mendoza
doaj +1 more source
Spatially Informed Cell Type Deconvolution for Spatial Transcriptomics
Nature Biotechnology, 2022 Many spatially resolved transcriptomic technologies do not have single-cell resolution but measure the average gene expression for each spot from a mixture of cells of potentially heterogeneous cell types.
Ying Ma, Xiang Zhou
semanticscholar +1 more source
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
Science Translational Medicine, 2022 Nociceptors are specialized sensory neurons that detect damaging or potentially damaging stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia.
Diana Tavares-Ferreira +14 more
semanticscholar +1 more source
Gene Regulation and Transcriptomics [PDF]
Current Issues in Molecular Biology, 2021 Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition from a vertebrate host to a tick vector and transmission from a tick vector to a vertebrate host.
Samuels, D. Scott +8 more
openaire +3 more sources
Frontiers in Molecular Neuroscience, 2016 Amyotrophic lateral sclerosis (ALS) is a progressive fatal multisystemic neurodegenerative disorder caused by preferential degeneration of upper and lower motor neurons.
Stefanie Krüger +15 more
doaj +1 more source
Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli [PDF]
, 2017 Escherichia coli that are capable of causing human disease are often classified into pathogenic variants (pathovars) based on their virulence gene content. However, disease-associated hybrid E.
Daugherty, Sean C +6 more
core +2 more sources
Evolution of the unspliced transcriptome [PDF]
BMC Evolutionary Biology, 2015 Despite their abundance, unspliced EST data have received little attention as a source of information on non-coding RNAs. Very little is know, therefore, about the genomic distribution of unspliced non-coding transcripts and their relationship with the much better studied regularly spliced products. In particular, their evolution has remained virtually
Engelhardt, Jan, Stadler, Peter F.
openaire +5 more sources
Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure
Nature Cardiovascular Research, 2022 Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell transcriptomics have revolutionized our understanding of cell composition and associated gene expression.
Andrew L. Koenig +13 more
semanticscholar +1 more source