TROM: A Testing-based Method for Finding Transcriptomic Similarity of Biological Samples [PDF]
Statistics in Biosciences 9 (2017) 105-136, 2016 Comparative transcriptomics has gained increasing popularity in genomic research thanks to the development of high-throughput technologies including microarray and next-generation RNA sequencing that have generated numerous transcriptomic data. An important question is to understand the conservation and differentiation of biological processes in ...
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A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing [PDF]
, 2010 Transcriptomics (at the level of single cells, tissues and/or whole organisms) underpins many fields of biomedical science, from understanding the basic cellular function in model organisms, to the elucidation of the biological events that govern the ...
Aaron R. Jex +95 more
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Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli [PDF]
, 2017 Escherichia coli that are capable of causing human disease are often classified into pathogenic variants (pathovars) based on their virulence gene content. However, disease-associated hybrid E.
Daugherty, Sean C +6 more
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Imaging the transcriptome [PDF]
Molecular Systems Biology, 2013 Mol Syst Biol. 9: 710 It is well known that genetically identical cells can display a high variability in their gene expression profiles. This phenomenon has a profound impact on a myriad of cellular processes, ranging from differentiation to signaling and drug resistance.
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Advancement of science, 2023 Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation of the spatial localization of transcripts and related analyses in various applications for biological systems.
Han-Eol Park +8 more
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Comparative transcriptomics in the Triticeae [PDF]
BMC Genomics, 2009 Barley and particularly wheat are two grass species of immense agricultural importance. In spite of polyploidization events within the latter, studies have shown that genotypically and phenotypically these species are very closely related and, indeed, fertile hybrids can be created by interbreeding.
Schreiber, Andreas W. +11 more
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SERpredict: Detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements [PDF]
BMC Genetics 2007 8:78, 2008 Background: Transposed elements (TEs) are known to affect transcriptomes, because either new exons are generated from intronic transposed elements (this is called exonization), or the element inserts into the exon, leading to a new transcript. Several examples in the literature show that isoforms generated by an exonization are specific to a certain ...
arxiv +1 more source
Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma. [PDF]
, 2019 As the most common cancer in men, prostate cancer is molecularly heterogeneous. Contributing to this heterogeneity are the poorly understood metabolic adaptations of the two main types of prostate cancer, i.e., adenocarcinoma and small cell ...
Alumkal, Joshi J +8 more
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Advanced NanoBiomed Research, 2021 Despite their ubiquity in personal care products, the health implications of titanium dioxide (TiO2) nanomaterials (NMs) are under strenuous investigation for their potential as a carcinogen, whereas other evidence has shown links with premature ageing ...
Laura-Jayne A. Ellis +6 more
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Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems
Science immunology, 2023 Whereas the cellular and molecular features of human inflammatory skin diseases are well characterized, their tissue context and systemic impact remain poorly understood.
R. Castillo +24 more
semanticscholar +1 more source