Results 71 to 80 of about 398,969 (379)

MIREyA: a computational approach to detect miRNA-directed gene activation [version 2; peer review: 1 approved, 2 approved with reservations]

open access: yesF1000Research, 2021
Emerging studies demonstrate the ability of microRNAs (miRNAs) to activate genes via different mechanisms. Specifically, miRNAs may trigger an enhancer promoting chromatin remodelling in the enhancer region, thus activating the enhancer and its target ...
Anna Elizarova   +3 more
doaj   +1 more source

Diatom Proteomics Reveals Unique Acclimation Strategies to Mitigate Fe Limitation [PDF]

open access: yes, 2015
Phytoplankton growth rates are limited by the supply of iron (Fe) in approximately one third of the open ocean, with major implications for carbon dioxide sequestration and carbon (C) biogeochemistry.
Boyd, Philip W.   +7 more
core   +1 more source

Deciphering spatial domains from spatially resolved transcriptomics with an adaptive graph attention auto-encoder

open access: yesNature Communications, 2021
Recent advances in spatially resolved transcriptomics have enabled comprehensive measurements of gene expression patterns while retaining the spatial context of the tissue microenvironment.
Kangning Dong, Shihua Zhang
semanticscholar   +1 more source

Standards and infrastructure for managing experimental metadata [PDF]

open access: yes, 2009
*See also the "related presentation":http://precedings.nature.com/documents/3145/version/1* We present an infrastructure that leverages synergistic reporting standards and ontologies^1,2,3,4,5^ to create a common structured ...
Chris Taylor   +7 more
core   +2 more sources

Identifying spatial domain by adapting transcriptomics with histology through contrastive learning

open access: yesBriefings Bioinform., 2023
Recent advances in spatial transcriptomics have enabled measurements of gene expression at cell/spot resolution meanwhile retaining both the spatial information and the histology images of the tissues.
Yuansong Zeng   +7 more
semanticscholar   +1 more source

BcCluster: a bladder cancer database at the molecular level [PDF]

open access: yes, 2016
Background: Bladder Cancer (BC) has two clearly distinct phenotypes. Non-muscle invasive BC has good prognosis and is treated with tumor resection and intravesical therapy whereas muscle invasive BC has poor prognosis and requires usually systemic ...
Bhat, Akshay   +5 more
core   +3 more sources

Human Pulmonary Tuberculosis: Understanding the Immune Response in the Bronchoalveolar System

open access: yesBiomolecules, 2022
Mycobacterium tuberculosis, the causal agent of one of the most devastating infectious diseases worldwide, can evade or modulate the host immune response and remain dormant for many years. In this review, we focus on identifying the local immune response
María Teresa Herrera   +6 more
doaj   +1 more source

Characterization of key triacylglycerol biosynthesis processes in rhodococci. [PDF]

open access: yes, 2016
Oleaginous microorganisms have considerable potential for biofuel and commodity chemical production. Under nitrogen-limitation, Rhodococcus jostii RHA1 grown on benzoate, an analog of lignin depolymerization products, accumulated triacylglycerols (TAGs ...
Amara, Sawsan   +5 more
core   +2 more sources

Spatial Transcriptomics: Technical Aspects of Recent Developments and Their Applications in Neuroscience and Cancer Research

open access: yesAdvancement of science, 2023
Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation of the spatial localization of transcripts and related analyses in various applications for biological systems.
Han-Eol Park   +8 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

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