Results 111 to 120 of about 1,640,128 (340)

Mathematical Modelling of Variable Porosity Coatings for Dual Drug Delivery [PDF]

, 2017
In this paper we describe a theoretical mathematical model of dual drug delivery from a durable polymer coated medical device. We demonstrate how the release rate of each drug may in principle be controlled by altering the initial loading configuration
McGinty, Sean, Pontrelli, Giuseppe
core  

A Versatile Engineering Platform for the Fabrication of Prosthetic Venous Valves Using Electrospinning

Advanced Healthcare Materials, EarlyView.
Percutaneous prosthetic venous valves are fabricated by embedding stents in an electrospun matrix that extends luminally to form leaflets. The design shields leaflets from hyperplastic cells, isolates struts from blood contact, and avoids discrete anchoring points.
Dario Arcuti, Salma Mansi, Dominic Biebl, Malin Reuter, Maximilian Grab, José Carlos Rodríguez‐Cabello, Petra Mela   +6 more
wiley   +1 more source

Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery

Frontiers in Bioengineering and Biotechnology, 2018
Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine.
Sabine Szunerits, Rabah Boukherroub
doaj   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Current Advancements in Transdermal Biosensing and Targeted Drug Delivery

Sensors, 2019
In this manuscript, recent advancements in the area of minimally-invasive transdermal biosensing and drug delivery are reviewed. The administration of therapeutic entities through the skin is complicated by the stratum corneum layer, which serves as a ...
Prem C. Pandey, Shubhangi Shukla, Shelby A. Skoog, Ryan D. Boehm, Roger J. Narayan   +4 more
doaj   +1 more source

Flexible Polypyrrole‐Based pH Sensors via Oxidative Chemical Vapor Deposition

Advanced Healthcare Materials, EarlyView.
Oxidative chemical vapor deposition (oCVD) of polypyrrole (PPy) thin films yields flexible, electrically conductive, and biocompatible pH sensors for monitoring on‐skin biological events. The highly sensitive, oCVD PPy skin‐conformal sensors enable real‐time, spatially resolved sensing of dynamic pH changes within physiologically relevant ranges (4–9 ...
Adrivit Mukherjee, Federico Ferrari, David Garcia Romero, Ilaria Squillante, Job Schoenmaker, Hamoon Hemmatpour, Anton Terpstra, Peter Dijkstra, Julien Es Sayed, L. Jan Anton Koster, Maria Antonietta Loi, Petra Rudolf, Giuseppe Portale, Ajay Giri Prakash Kottapalli, Marleen Kamperman, Ranjita K. Bose   +15 more
wiley   +1 more source

A systematic approach to the formulation of anti-onychomycotic nail patches [PDF]

, 2018
Nail patches have a potential role as drug carriers for the topical treatment of nail diseases such as onychomycosis, a common condition. O ur aim was therefore to develop a systematic and novel appr oach to the formulat ion of a simple drug -in-adhesive
Charalambides, MN, Kinloch, AJ, Mohammed, IK, Murdan, K, Rizi, K, Xu, K   +5 more
core   +1 more source

Electro‐Stimulated Graphene‐Polymer Nanocomposites Enable Wearable Patches With Feedback‐Controlled Drug Release

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Stimuli‐responsive nanomaterials capable of spatiotemporal control over drug release are of nanocomposite patch (“e‐Medi‐Patch”) engineered from biodegradable polycaprolactone (PCL), graphene nanoplatelets, and a redox‐active therapeutic, niclosamide. The hierarchical composite integrates π‐π interactions between aromatic drug molecules
Santosh K. Misra, Ketan Dighe, Pranay Saha, Teresa Aditya, Muhammad S. Khan, Maha Alafeef, Parikshit Moitra, Dipanjan Pan   +7 more
wiley   +1 more source

Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels

Journal of Pharmacy & Pharmaceutical Sciences, 2016
Organogels have emerged as an alternative carrier for small and macromolecules via transdermal, oral, rectal and ophthalmic routes. Pluronic lecithin organogels (PLO gels) are lecithin-based organogels widely used in compounding pharmacies as a vehicle ...
Hashem Alsaab, Sindhu Prabha Bonam, Dherya Bahl, Pallabita Chowdhury, Kenneth Alexander, Sai HS. Boddu   +5 more
doaj   +1 more source

Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate.

International journal of pharmaceutics, 2020
Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) and it is mainly administered either orally or by subcutaneous (SC) injection, which are not so satisfactory.
I. Tekko, Gaoyun Chen, Juan Domínguez-Robles, R. Thakur, Iman Hamdan, Lalitkumar K. Vora, E. Larrañeta, J. McElnay, H. McCarthy, M. Rooney, R. Donnelly   +10 more
semanticscholar   +1 more source