Results 171 to 180 of about 23,063 (265)

Itraconazole-Loaded Polycaprolactone Nanoparticle Gel for Enhanced Transdermal Delivery: Development, Characterization, and ex vivo Evaluation. [PDF]

Int J Nanomedicine
Hussain S, Malik NS, Tulain UR, Erum A, Mahmood A, Akram S, Javaid A, Jabeen A, Shao C, Wang S, Younas A.   +10 more
europepmc   +1 more source

Effects of descending aortic occlusion for massive obstetric hemorrhage: Nationwide analysis of maternal death in Japan

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the effects of aortic occlusion (AO) on severe postpartum hemorrhage (PPH)—a leading cause of preventable maternal mortality—using a nationwide maternal death registry in Japan. Methods A nationwide retrospective observational study of hemorrhage‐related maternal deaths was conducted in Japan between 2010 and 2024 ...
Makoto Aoki, Soichiro Obata, Manabu Ogoyama, Koki Shimura, Yutaka Iwagoi, Makiko Kasahara, Yui Yoshida, Saya Yamashita, Akihiko Sekizawa, Koji Hashii, Masahiko Nakata, Takeshi Murakoshi, Shinji Katsuragi, Hiroaki Tanaka, Kayo Tanaka, Yoko Sagara, Tatsuya Arakaki, Junichi Hasegawa, on behalf of the Working group of Maternal Mortality 2025 in the Japan Association of Obstetricians and Gynecologists   +18 more
wiley   +1 more source

Mould-Free Microneedles in a Single Step: 3D Printing with Photopolymer Resins for Transdermal Delivery. [PDF]

Pharmaceutics
Meshram RN, Lamprou DA.
europepmc   +1 more source

Membranous dysmenorrhea and decidual casts: A scoping review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Membranous dysmenorrhea, characterized by the expulsion of intact endometrial tissue rather than gradual dissolution during menstruation, occasionally presents as a decidual cast—a complete triangular mold of the uterine cavity. This poorly understood condition is likely underdiagnosed.
Lovisa Brehmer, Hedvig Engberg
wiley   +1 more source

Ethosome-Based Colloidal Systems for Transdermal Delivery: The Role of Biosurfactant in Enhancing Stability and Efficacy. [PDF]

Materials (Basel)
Chudzińska-Skorupinska J, Wawrzyńczak A, Feliczak-Guzik A.   +2 more
europepmc   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

Dextran-modified dissolving microneedle patches for effective amelioration of psoriasis through transdermal delivery of hesperidin. [PDF]

Int J Pharm X
Etemadi N, Varshosaz J, Shamaeizadeh N, Renani AM, Minaiyan M.   +4 more
europepmc   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

Black phosphorus‐based photothermal disruption of cancer‐associated fibroblast barriers and tumor‐associated macrophage targeting to enhance anti‐PD‐L1 immunotherapy in triple‐negative breast cancer

Interdisciplinary Medicine, EarlyView.
MBB modulates the TNBC tumor microenvironment by targeting TAM/CXCL1 and facilitates anti‐PD‐L1 therapy by disrupting CAF barriers via its photothermal effect. This combined strategy subsequently enhances the efficacy of PD‐L1 mAb and suppresses TNBC progression, metastasis, and recurrence.
Bo Pan, Shicui Hong, Xinyue Wang, Yanghang Li, Cai Wang, Yaxiao Liu, Ying Chen, Chen Fang, Yifeng Zheng, Shengqi Wang, Juping Zhang, Neng Wang, Zhiyu Wang   +12 more
wiley   +1 more source