Results 191 to 200 of about 23,147 (265)

Hyaluronic acid microneedle patch for transdermal delivery of naringin-loaded PEGylated terpesomes in a rat model of rheumatoid arthritis: Modulation TGF-β1, oxidative stress, and inflammation. [PDF]

Int J Pharm X
Elhabal SF, Hamdan AME, Shoela MS, Morsy SAA, Elsharkawy AM, Saad-Eldin R, Allam S, Ewedah TM, Fouad MA, Elsayed M, Elmoneim HMA, Albar HT, Abdelgawad WY, Hassan FE.   +13 more
europepmc   +1 more source

Pregnancy‐ and lactation‐associated osteoporosis: A position statement of the IAPM, IOF, ECTS, ESCEO, IMS, and EMAS

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pregnancy‐ and lactation‐associated osteoporosis (PLO) is a syndrome characterized by fragility fractures (most commonly vertebral, often multiple) occurring in late pregnancy or the early postpartum period. This position statement summarizes the current knowledge of PLO, and the recommended procedure for assessment, diagnosis and treatment ...
Peyman Hadji, Apostolos Athanasiadis, Maria‐Luisa Brandi, Marlene Chakhtoura, Manju Chandran, Frank Chervenak, Amos Grünebaum, Irene Lambrinoudaki, Willem F. Lems, Apostolos M. Mamopoulos, Eugene McCloskey, Rossella E. Nappi, Jessica Pepe, Jean‐Yves Reginster, René Rizzoli, Petra Stute, Şansın Tuzun, Amanda J. Vincent, Maria Belen Zanchetta, M. Carola Zillikens, Ioannis Kyvernitakis   +20 more
wiley   +1 more source

Vacuum compression-molded polyvinyl alcohol microneedles for sustained three-day transdermal delivery of palonosetron hydrochloride. [PDF]

Drug Deliv Transl Res
Ghosh M, Kshirsagar SM, Kipping T, Banga AK.   +3 more
europepmc   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

Ionic liquid-iontophoresis mediates transdermal delivery of sparingly soluble drugs. [PDF]

Drug Deliv
Gao W, Xing W, Tang Z, Wang Q, Yu W, Zhang Q.   +5 more
europepmc   +1 more source

Black phosphorus‐based photothermal disruption of cancer‐associated fibroblast barriers and tumor‐associated macrophage targeting to enhance anti‐PD‐L1 immunotherapy in triple‐negative breast cancer

Interdisciplinary Medicine, EarlyView.
MBB modulates the TNBC tumor microenvironment by targeting TAM/CXCL1 and facilitates anti‐PD‐L1 therapy by disrupting CAF barriers via its photothermal effect. This combined strategy subsequently enhances the efficacy of PD‐L1 mAb and suppresses TNBC progression, metastasis, and recurrence.
Bo Pan, Shicui Hong, Xinyue Wang, Yanghang Li, Cai Wang, Yaxiao Liu, Ying Chen, Chen Fang, Yifeng Zheng, Shengqi Wang, Juping Zhang, Neng Wang, Zhiyu Wang   +12 more
wiley   +1 more source

Influence of Choline-Based Ionogel on Transdermal Delivery of Vancomycin Hydrochloride. [PDF]

Mol Pharm
Datta D, Bandi SP, Venuganti VVK.
europepmc   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Transdermal delivery of timolol maleate using hydrogel microneedles for the treatment of infantile haemangiomas. [PDF]

Mater Today Bio
Lin X, Kuang T, Wang L, Cai W, Yang L, Guo C, Pan X, Wang Y, Gao Q, Nan K, Li L.   +10 more
europepmc   +1 more source

A wearable self-aid microneedle chip based on actively transdermal delivery of epinephrine. [PDF]

Microsyst Nanoeng
Jin C, Guo P, Li W, Zhu W, Li C, Ma J, Li J, Li D, He J, Pu Z.   +9 more
europepmc   +1 more source