Results 201 to 210 of about 1,412,226 (251)

Microneedle-mediated transdermal delivery of siRNA-loaded nanoparticles for atopic dermatitis therapy by disrupting cuproptosis-pyroptosis crosstalk. [PDF]

J Nanobiotechnology
Yu P, Fang C, Luo Z, Hao L, Li K, Yan R, Ma S, Wang G, Cao Q, Dong J, Chen X, Li J, Liu P, Hu S, Peng C.   +14 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Transcutaneous auricular vagus nerve stimulation in drug‐resistant epilepsy: A randomized, sham‐controlled crossover trial with exploratory EEG and MRI response phenotyping

Epilepsia Open, EarlyView.
Abstract Objective Transcutaneous auricular vagus nerve stimulation (taVNS) is a noninvasive neuromodulation strategy for drug‐resistant epilepsy, but clinical response is heterogeneous. We examined whether electroencephalographic (EEG) and structural magnetic resonance imaging (MRI) phenotypes were associated with active‐specific clinical benefit from
Sung Jun Hong, Seok‐Yeol Yang, Eun Kyung Bok, Jung Chul Lee, Yeonggin Kim, Kyousik Min, Young‐Min Shon   +6 more
wiley   +1 more source

Topical framework nucleic acid transdermal delivery system for reprogramming cutaneous dendritic cells to maintain graft immune homeostasis. [PDF]

Bioact Mater
Qin X, Wei T, Zhang Z, Qin H, Lin Y, Song J.   +5 more
europepmc   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source

Thermally Stable Nanoarchitectonics of Bicellar Nanocarriers for Superior Transdermal Delivery of <i>Centella asiatica</i> Extracts. [PDF]

ACS Appl Mater Interfaces
Eom S, Kim ER, Jung H, Lee J, Song C, Yoo JW, Baek HS, Lee J, Jung D, Kwak MK, Jeong HE, Jung H.   +11 more
europepmc   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Correction: Transdermal delivery of CRISPR/Cas9-mediated melanoma gene therapy via polyamines-modified thermosensitive hydrogels. [PDF]

J Nanobiotechnology
Li M, Zhou S, Zhang S, Xie X, Nie J, Wang Q, Ma L, Cheng Y, Luo J.   +8 more
europepmc   +1 more source

Untethered Electrical Stimulation Using Optoelectricity and Piezoelectricity for Tissue Regeneration

FlexTech, EarlyView.
Untethered electrical stimulation from optoelectronic and piezoelectric materials can aid regeneration of damaged tissue. ABSTRACT Electrical signals are increasingly recognized as important regulators of tissue development and regeneration, with outcomes linked to behaviors including proliferation, differentiation, cell migration, and more.
Ryan Yao, Baochun Xu, Cunjiang Yu
wiley   +1 more source

Core-Shell Silk Fibroin Hydrogel Microneedles Functionalized with Antibody-Binding Domains for Transdermal Delivery. [PDF]

Biomimetics (Basel)
Lee MK, Lee AS, Kim CS.
europepmc   +1 more source