Results 221 to 230 of about 23,063 (265)
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Journal of Controlled Release
Gene delivery has revolutionized conventional medical approaches to vaccination, cancer, and autoimmune diseases. However, current gene delivery methods are limited to either intravenous administration or direct local injections, failing to achieve well biosafety, tissue targeting, drug retention, and transfection efficiency for desired therapeutic ...
Wentao, Zhang +5 more
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Gene delivery has revolutionized conventional medical approaches to vaccination, cancer, and autoimmune diseases. However, current gene delivery methods are limited to either intravenous administration or direct local injections, failing to achieve well biosafety, tissue targeting, drug retention, and transfection efficiency for desired therapeutic ...
Wentao, Zhang +5 more
openaire +2 more sources
Transdermal delivery of steroids
Contraception, 1989The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of administration is a real breakthrough ...
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Transdermal delivery of antisense compounds
Advanced Drug Delivery Reviews, 2000Antisense technology holds tremendous promise for therapeutic applications and the study of gene function. A broadly applicable route of administration that would provide for non-invasive, simple, and convenient delivery is highly desirable. Application of oligonucleotides to the skin may represent a solution to the delivery question for both local ...
R M, Brand, P L, Iversen
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Episodic Transdermal Delivery of Testosterone
Molecular Pharmaceutics, 2012Film-forming lotions, precast films and adhesive patches containing testosterone (T) were prepared by compounding vinylic, acrylic and cellulosic polymers with a variety of excipients in order to achieve distribution of T in domains of heterogeneity within multicomponent matrices.
Ritu, Malik +3 more
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Optimised transdermal delivery of pravastatin
International Journal of Pharmaceutics, 2015Wiechers' programme "Formulating for Efficacy" initiated a new strategy to optimise the oil phase of topical formulations in order to achieve optimal transdermal drug delivery. This new approach uses the "Delivery Gap Theory" on any active pharmaceutical ingredients (APIs) to test if it could enhance transdermal drug delivery.
Cornel Burger +3 more
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Transdermal delivery of levonorgestrel
Medicinal Research Reviews, 1991This review of the research and development of transdermal delivery systems for levonorgestrel and combinations of levonorgestrel and estrogens also contains explanatory material on skin structure and absorption of drugs by diffusion and partition permeability and use of enhancers to facilitate absorption use of pro-drugs and derivatives and cutaneous ...
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Transdermal drug delivery devices
Clinics in Dermatology, 1989Abstract The concept of transdermal delivery is not new, but until recently, its therapeutic application was restricted to creams and ointments which are messy and difficult to apply uniformly to ensure reproducible dosing. In the late 1970s, technology was developed that permitted the construction of multicomponent devices embodying the ability to ...
P W, Ledger, K C, Nichols
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The transdermal delivery of fentanyl
European Journal of Pharmaceutics and Biopharmaceutics, 2013The fentanyl patch is one of the great commercial successes in transdermal drug delivery. The suitability of this molecule for delivery through skin had been identified in the 1970s, and subsequently, a number of transdermal formulations became available on the market.
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Cyclodextrins in transdermal and rectal delivery
Advanced Drug Delivery Reviews, 1999Transdermal and rectal routes of drugs are very important as a useful supplement of oral routes and the direct exposing method of drugs when the systemic and local effects are required. The widespread use of parent cyclodextrins (CDs) and chemically modified CD derivatives (CD derivatives) for in-vitro and in-vivo dermal and rectal drug delivery have ...
, Matsuda, , Arima
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Nanoparticle delivery for transdermal HRT
Maturitas, 2012Nanomedicine is an emerging technology and the first nano-engineered medical products have come to light in the last decade. Transdermal drug delivery has significant advantages compared to other routes of drug administration. Nanoparticles unique physical and chemical properties enable transport of substances directly into the skin.
Pilar, Valenzuela, James A, Simon
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