Results 71 to 80 of about 23,147 (265)

A Multimodal Haptic Feedback Interface with Thin‐Film Compliant Mechanism

Advanced Science, EarlyView.
Multimodal haptic devices can trigger different mechanoreceptors, enabling richer haptic information. This study presents an electromagnetic multimodal haptic device capable of delivering indentation, stretch, and vibration stimuli. The device is enabled by a novel polymer thin‐film compliant mechanism that provides high translational compliance along ...
Jingjing Wan, Emanuele Nicotra, James Davies, Kefan Zhu, Quang Anh Nguyen, Sinuo Zhao, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Hermione Truong, Patrick Pruscino, Tan Huynh, Phuoc Thien Phan, Hoang‐Phuong Phan, Nigel Hamilton Lovell, Thanh Nho Do   +15 more
wiley   +1 more source

Transdermal hormone therapy in postmenopausal women: A review of metabolic effects and drug delivery technologies

Drug Design, Development and Therapy, 2008
Nathan W Kopper, Jennifer Gudeman, Daniel J ThompsonKV Pharmaceutical, St. Louis, MO, USAAbstract: Vasomotor symptoms (VMS) associated with menopause can cause significant discomfort and decrease the quality of life for women in the peri-menopausal and ...
Nathan W Kopper, Jennifer Gudeman
doaj  

Transdermal delivery of antenatal steroids to promote fetal lung maturation: Proof of principle data from sheep and non-human primate models

BMC Medicine
Background Antenatal steroids (ANS) are routinely administered to women at risk of preterm birth to accelerate fetal lung maturation. Despite extensive clinical use, dosing and route of ANS administration remain unoptimized beyond intramuscular (IM ...
Sean W. D. Carter, Ayça Altay Benetti, Ryan Tze Liang Sia, Giorgia Pastorin, Erin L. Johnson, Kay Yi Michelle Seah, Haruo Usuda, Hannah R. S. Watson, Yusaku Kumagai, Qin Wei, Xiawen Liu, Roberto Orefice, Marianne Bon, Zubair Amin, Agnihotri Biswas, Tsukasa Takahashi, Noriyoshi Mochii, Yuya Saito, Hideyuki Ikeda, Masatoshi Saito, Mahesh A. Choolani, Sebastián E. Illanes, Matthew W. Kemp   +22 more
doaj   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

TRANSDERMAL DRUG DELIVERY AND METHODS TO ENHANCE IT

Вестник трансплантологии и искусственных органов, 2016
The paper presents the common methods employed in recent years for enhancing transdermal delivery of drug substances when applying transdermal therapeutic delivery systems.
E. G. Kuznetsova, V. A. Ryzhikova, L. A. Salomatina, V. I. Sevastianov   +3 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Developing a commercial air ultrasonic ceramic transducer to transdermal insulin delivery

Journal of Medical Signals and Sensors, 2015
The application of low-frequency ultrasound for transdermal delivery of insulin is of particular public interest due to the increasing problem of diabetes.
Nasrollah Jabbari, Mohammad Hossein Asghari, Hassan Ahmadian, Peyman Mikaili   +3 more
doaj  

Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals

Advanced Science, EarlyView.
A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu, Sultan Mahmud, Mali Halac, Asif Iftekhar Omi, Domenica Sofia Baez Rodas, Jeremiasz Dados, Chaojun Cheng, Anyu Jiang, Cameron Wallace, Anvi Singh, Erin Patrick, Baibhab Chatterjee, Shriya Srinivasan, Adam Khalifa   +13 more
wiley   +1 more source

Discovery of a Reversible Sub‐Picomolar Thrombin Inhibitor Using DCC

Angewandte Chemie, EarlyView.
An ultrapotent yet fully reversible trivalent thrombin inhibitor discovered through screening a large dynamic combinatorial library (DCL) of 125 000 members of self‐assembled fragments. The innovative approach leverages size‐exclusion‐based affinity selection, coupled with MALDI‐TOF mass spectrometry readout, enabling the full workflow to be completed ...
Millicent Dockerill, Richard J. Payne, Nicolas Winssinger   +2 more
wiley   +2 more sources