Results 101 to 110 of about 3,038,700 (252)

Delivery Strategies for Colchicine as a Critical Dose Drug: Reducing Toxicity and Enhancing Efficacy

Pharmaceutics
Colchicine (COL), a widely used natural drug, has potent anti-inflammatory effects; however, as a narrow therapeutic index drug, its clinical application is limited by its serious gastrointestinal adverse effects, and only oral formulations are currently
Yaran Lei, Yulu Yang, Guobao Yang, Ao Li, Yang Yang, Yuli Wang, Chunsheng Gao   +6 more
doaj   +1 more source

Microemulsions: Transdermal Drug Delivery Systems With Enhanced Bioavailability [PDF]

, 2019
Microemulsions are preferred because of its advantages like low cost of preparation and enhanced bioavailability due to increased absorption of drug through skin which is achieved by adding penetration enhancers. Most frequently used permeation enhancers
Santosh Kumar, Rada, Sai Pravallika, T V
core   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

A Review on Current Status and Future Potential of Transdermal Patches as a Promising Drug Delivery System

Journal of Mazandaran University of Medical Sciences, 2019
Transdermal patches are now widely used in topical and transdermal drug delivery systems (TDDS). Up to now, TDDS has been used in several conditions, such as smoking cessation, analgesic effect, nausea, contraception, and hormone therapy.
Majid Saeedi, Ali Farmoudeh, Anahita Rezaeiroshan   +2 more
doaj  

Handbook of non-invasive drug delivery systems : science and technology /

, 2009
With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery.
Kulkarni, Vitthal S.
core  

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

Formulation and Evaluation of Galantamine Gel as Drug Reservoir in Transdermal Patch Delivery System

The Scientific World Journal, 2015
Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal ...
Woo Fong Yen, Mahiran Basri, Mansor Ahmad, Maznah Ismail   +3 more
doaj   +1 more source

PHYSICAL APPROACH TO TRANSDERMAL DRUG DELIVERY: A REVIEW [PDF]

, 2017
Transdermal drug delivery system (TDDS) is the topically administered medication, which when applied to the skin, delivers the drug through the skin for systemic effect at a predetermined and controlled rate.
Chinmay Bhangale, T A Deshmukh, Bhangale, Chinmay, Deshmukh, T A, Mayur Chaudhari, Neha Jawale, Jawale, Neha, Chaudhari, Mayur   +7 more
core   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug Delivery Systems

Applied Sciences
Over the past few decades, notable advancements have been made in the field of transdermal drug delivery systems (TDDSs), presenting a promising alternative to conventional oral drug administration. This comprehensive review aims to enhance understanding
Meera Alex, Nour M. Alsawaftah, Ghaleb A. Husseini   +2 more
doaj   +1 more source