Results 81 to 90 of about 20,334 (253)

Degradation Mechanisms, Encapsulation‐Based Stabilization, and Analytical Detection of Vitamin A

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Vitamin A is an important lipid‐soluble micronutrient essential for vision, immune function, and overall growth and development. However, vitamin A is unstable and susceptible to environmental factors because of its conjugated structure and inherent chemical reactivity.
Latheesha Abeywardana, Thambaramala V. Gamage, Tanoj K. Singh, Shuaifei Zhao, Amy Logan, Lingxue Kong   +5 more
wiley   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, EarlyView.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Cutting-edge advances in transethosomes and nanoethosomes for transdermal drug delivery

Discover Chemistry
Transdermal drug delivery has long faced challenges such as poor skin permeation and low bioavailability of therapeutics. Conventional systems often fail to overcome the skin’s barrier properties, necessitating advanced vesicular carriers.
Prasun Patra
doaj   +1 more source

Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

British Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić, Elvira Meni Maria Gkrinia, Patrick Eustaquio, Andrea Katrin Faour, Dinko Vitezić   +4 more
wiley   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Comparative Analysis of Loxoprofen Loaded Ethosomal Gel Formulations Incorporating Carbopol and Hydroxypropyl Methylcellulose

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Transdermal delivery is recognized as one of  the most advantageous non-invasive drug  delivery technologies; but the skin's natural  barrier, particularly the stratum corneum,  restricts drug permeation.
Sarah Jabbar Abd Alhur, Hasanain Shakir Mahmood, Pegah Khosravian Dehkordi   +2 more
doaj   +1 more source

Safety concerns reported by coroners following fentanyl patch fatalities in England, Wales and Northern Ireland between 1997 and 2024

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To identify safety concerns reported by coroners following fentanyl patch‐related deaths in England, Wales and Northern Ireland, and determine differences in coronial reporting. Methods A systematic case series linking the National Programme on Substance Use Mortality (NPSUM) and the Preventable Deaths Tracker (PDT) (https ...
Eman Mshari, Caroline S. Copeland, Georgia C. Richards   +2 more
wiley   +1 more source

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

Poly(lactic‐co‐glycolic acid) microsphere loaded dissolving microneedles for sustained and coordinated transdermal delivery of desogestrel and ethinyl estradiol

Bulletin of the Korean Chemical Society, EarlyView.
PLGA‐based sustained‐release microneedles were developed for the delivery of desogestrel and ethinyl estradiol. The system enabled coordinated release of both drugs, suggesting its potential to improve dosing convenience as a long‐acting contraceptive platform.
Young‐Jin Kim, Byeongsu Kim, Sokyoung Joo, So‐Jeong Jeong, Chang‐Soo Han, Chun‐Woong Park   +5 more
wiley   +1 more source

Transdermal microneedle patch for antioxidants release

Discover Materials
Polymer based microneedle transdermal drug delivery system fits the criterion for an efficient patient compliant drug delivery system of the future. Smart and controlled microneedle drug delivery systems remain an emerging research area.
Samuel Mugo, Scott Robertson, Weihao Lu
doaj   +1 more source