Results 1 to 10 of about 1,297,886 (175)
The Cold Case Files of rAAV Capsid Influence on Transduction: New Leads [PDF]
VirusesAdeno-associated virus (AAV) is a prevalent vector in viral gene therapy. Given its importance, significant efforts focus on engineering the capsid residues on the exterior surface to increase cell/tissue-specific binding to cellular receptors or to ...
Sara K. Powell
doaj +2 more sources
Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles
Frontiers in Molecular Neuroscience, 2022 Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of gene over-expression in the vestibular end organs. However, AAV has limited usefulness for delivering a large gene, or multiple genes, due to its small packaging capacity (<
Zhong-Rui Chen +19 more
doaj +1 more source
Transductive Ordinal Regression [PDF]
IEEE Transactions on Neural Networks and Learning Systems, 2012 Ordinal regression is commonly formulated as a multi-class problem with ordinal constraints. The challenge of designing accurate classifiers for ordinal regression generally increases with the number of classes involved, due to the large number of labeled patterns that are needed.
Seah, Chun-Wei +2 more
openaire +4 more sources
Biomedicines, 2021 NK cells are the first line of defense against viruses and malignant cells, and their natural functionality makes these cells a promising candidate for cancer cell therapy.
Maria A. Streltsova +5 more
doaj +1 more source
Frontiers in Immunology, 2022 The great clinical success of chimeric antigen receptor (CAR) T cells has unlocked new levels of immunotherapy for hematological malignancies. Genetically modifying natural killer (NK) cells as alternative CAR immune effector cells is also highly ...
Maren Soldierer +19 more
doaj +1 more source
Supporting Student Transduction of Meanings Across Modes in Primary School Astronomy
Frontiers in Communication, 2022 The multimodal nature of knowledge development and learning in science is now increasingly recognized. While researchers have focused on identifying how different representational modes afford meaning-making, the question of how students are guided to ...
Russell Tytler, Vaughan Prain
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background Despite the increasing progress in targeted and immune based-directed therapies for other solid organ malignancies, currently there is no targeted therapy available for TNBCs.
Murugan Kalimutho +9 more
doaj +1 more source
What Do We Hear When We Hear Microbe Sounds
Pulse, 2022 The concept of the Anthropocene, based on the premise that mankind has become a major geological force in its own right, has grown into a central theme with issues such as ecological crisis, climate change, or sustainable futures.
Emre Sünter
doaj +1 more source
The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?
Pharmaceuticals, 2021 Extended overuse and misuse of antibiotics and other antibacterial agents has resulted in an antimicrobial resistance crisis. Bacteriophages, viruses that infect bacteria, have emerged as a legitimate alternative antibacterial agent with a wide scope of ...
Ahmad Y. Hassan +3 more
doaj +1 more source
Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]
, 2017 The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C +3 more
core +1 more source