Results 21 to 30 of about 3,488,111 (320)
Mechanoelectrical transduction-related genetic forms of hearing loss
Current Opinion in Physiology, 2023 Hair cells of the mammalian cochlea are specialized mechanosensory cells that convert mechanical stimuli into electrical signals to initiate the neuronal responses that lead to the perception of sound. The mechanoelectrical transduction (MET) machinery of cochlear hair cells is a multimeric protein complex that consists of the pore forming subunits of ...
Jinsei, Jung, Ulrich, Müller
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The implications of alternative pre-mRNA splicing in cell signal transduction
Experimental and Molecular Medicine, 2023 Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing, key components of signal transduction pathways are no exception.
Sunkyung Choi, Namjoon Cho, Kee K. Kim
doaj +1 more source
Science Translational Medicine, 2020 Base editing in postnatal mice repairs a recessive hearing loss mutation, rescues sensory transduction, and transiently restores auditory function. At the base of deafness Mutations in the transmembrane channel-like 1 (TMC1) gene can cause hereditary ...
Wei-Hsi Yeh +9 more
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Expanding applications of chemical genetics in signal transduction [PDF]
Cell Cycle, 2012 Chemical genetics represents an expanding collection of techniques applied to a variety of signaling processes. These techniques use a combination of chemical reporters and protein engineering to identify targets of a signaling enzyme in a global and non-directed manner without resorting to hypothesis-driven candidate approaches.
Scott M, Carlson, Forest M, White
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Transfer of antibiotic resistance in Staphylococcus aureus [PDF]
, 2017 Staphylococcus aureus is a serious human pathogen with remarkable adaptive powers. Antibiotic-resistant clones rapidly emerge mainly by acquisition of antibiotic-resistance genes from other S. aureus strains or even from other genera.
Haaber, Jakob +2 more
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Protein transduction: an alternative to genetic intervention? [PDF]
Gene Therapy, 2001 Protein transduction, an emerging technology with potential applications in gene therapy, can best be described as the internalisation of proteins into the cell, from the external environment. This process relies on the inherent property of a small number of proteins and peptides of being able to penetrate the cell membrane. The transducing property of
K. Ford +3 more
semanticscholar +4 more sources
Developmental signal transduction pathways uncovered by genetic suppressors [PDF]
Proceedings of the National Academy of Sciences, 1996 We have found conditions for saturation mutagenesis by restriction enzyme mediated integration that result in plasmid tagging of disrupted genes. Using this method we selected for mutations in genes that act at checkpoints downstream of the intercellular signaling system that controls encapsulation in Dictyostelium ...
G, Shaulsky, R, Escalante, W F, Loomis
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Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter. [PDF]
, 2014 Lentiviral vectors almost universally use heterologous internal promoters to express transgenes. One of the most commonly used promoter fragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some enhancers, first
Cooper, Aaron R +3 more
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A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve. [PDF]
, 2018 open6siopenPatruno, M; Melotti L.; Gomiero, C; Sacchetto, R; Topel, O; Martinello, T.Patruno, M; Melotti, Luca; Gomiero, C; Sacchetto, R; Topel, O; Martinello ...
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Human Gene Therapy, 2020 Adeno-associated virus (AAV) vectors are quickly becoming the vectors of choice for therapeutic gene delivery. To date, hundreds of natural isolates and bioengineered variants have been reported.
Adrian Westhaus +19 more
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