Results 41 to 50 of about 3,488,111 (320)

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]

, 2019
Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan, Goode, Benjamin, Mondal, Gourish, Solomon, David A, Stevers, Meredith   +4 more
core   +2 more sources

Detecting rare gene transfer events in bacterial populations

Frontiers in Microbiology, 2014
Horizontal gene transfer (HGT) enables bacteria to access, share, and recombine genetic variation, resulting in genetic diversity that cannot be obtained through mutational processes alone.
Kaare Magne Nielsen, Kaare Magne Nielsen, Thomas eBøhn, Thomas eBøhn, Jeffrey Peter Townsend, Jeffrey Peter Townsend, Jeffrey Peter Townsend   +6 more
doaj   +1 more source

Transduction Enhancers Enable Efficient Human Adenovirus Type 5-Mediated Gene Transfer into Human Multipotent Mesenchymal Stromal Cells

Viruses, 2021
Human multipotent mesenchymal stromal cells (hMSCs) are currently developed as cell therapeutics for different applications, including regenerative medicine, immune modulation, and cancer treatment.
Robin Nilson, Olivia Lübbers, Linus Weiß, Karmveer Singh, Karin Scharffetter-Kochanek, Markus Rojewski, Hubert Schrezenmeier, Philip Helge Zeplin, Wolfgang Funk, Lea Krutzke, Stefan Kochanek, Astrid Kritzinger   +11 more
doaj   +1 more source

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
core   +1 more source

Genetic Control of Signal Transduction in Mouse Melanocytes.

Journal of Investigative Dermatology, 1989
At the final step of melanocyte differentiation in mouse hair follicles, the cells produce melanin. The type of melanin they produce is, however, determined by the tissue environment of hair follicles. In wild-type mice, melanocytes located in hair bulbs synthesize eumelanin at the beginning of hair growth.
Takeuchi, Takuji, Kobunai, Takashi, Yamamoto, Hiroaki   +2 more
openaire   +2 more sources

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Nature Genetics, 2010
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function ...
J. Dupuis, C. Langenberg, I. Prokopenko, R. Saxena, N. Soranzo, A. Jackson, E. Wheeler, N. Glazer, N. Bouatia-Naji, A. Gloyn, C. Lindgren, R. Mägi, A. Morris, J. Randall, T. Johnson, P. Elliott, Denis Rybin, G. Thorleifsson, V. Steinthorsdottir, P. Henneman, H. Grallert, A. Dehghan, J. Hottenga, C. Franklin, P. Navarro, Kijoung Song, A. Goel, J. Perry, J. Egan, T. Lajunen, N. Grarup, T. Sparsø, A. Doney, B. Voight, H. Stringham, Man Li, S. Kanoni, P. Shrader, Christine Cavalcanti-Proença, M. Kumari, L. Qi, N. Timpson, C. Gieger, C. Zabena, G. Rocheleau, E. Ingelsson, P. An, J. O’Connell, J. Luan, A. Elliott, S. Mccarroll, F. Payne, R. Roccasecca, F. Pattou, P. Sethupathy, K. Ardlie, Y. Ariyurek, B. Balkau, P. Barter, J. Beilby, Y. Ben-Shlomo, R. Benediktsson, A. Bennett, S. Bergmann, M. Bochud, E. Boerwinkle, A. Bonnefond, L. Bonnycastle, K. Borch-Johnsen, Y. Böttcher, E. Brunner, S. Bumpstead, G. Charpentier, Y. Chen, P. Chines, R. Clarke, L. Coin, M. Cooper, M. Cornelis, Gabriel J Crawford, L. Crisponi, I. Day, E. D. de Geus, J. Delplanque, C. Dina, M. Erdos, A. Fedson, A. Fischer-Rosinský, N. Forouhi, C. Fox, R. Frants, M. Franzosi, P. Galan, M. Goodarzi, J. Graessler, C. Groves, S. Grundy, R. Gwilliam, U. Gyllensten, S. Hadjadj, G. Hallmans, Naomi Hammond, Xijing Han, A. Hartikainen, N. Hassanali, C. Hayward, S. Heath, S. Hercberg, C. Herder, A. Hicks, D. Hillman, A. Hingorani, A. Hofman, J. Hui, J. Hung, B. Isomaa, P. Johnson, T. Jørgensen, A. Jula, M. Kaakinen, J. Kaprio, Y. Kesaniemi, M. Kivimaki, B. Knight, S. Koskinen, P. Kovacs, K. Kyvik, G. Lathrop, D. Lawlor, O. Le Bacquer, C. Lecoeur, Yun Li, V. Lyssenko, R. Mahley, M. Mangino, A. Manning, M. Martínez-Larrad, J. Mcateer, L. McCulloch, R. McPherson, C. Meisinger, D. Melzer, D. Meyre, B. Mitchell, M. Morken, S. Mukherjee, S. Naitza, Narisu Narisu, M. Neville, B. Oostra, M. Orrù, R. Pakyz, C. Palmer, G. Paolisso, C. Pattaro, Daniel S Pearson, J. Peden, N. Pedersen, M. Perola, A. Pfeiffer, I. Pichler, O. Polašek, D. Posthuma, Simon C. Potter, A. Pouta, M. Province, B. Psaty, W. Rathmann, N. W. Rayner, K. Rice, S. Ripatti, F. Rivadeneira, M. Roden, O. Rolandsson, A. Sandbaek, M. Sandhu, S. Sanna, A. Sayer, P. Scheet, L. Scott, U. Seedorf, S. Sharp, B. Shields, G. Sigurðsson, E. J. G. Sijbrands, A. Silveira, Laila Simpson, A. Singleton, N. Smith, U. Sovio, A. Swift, H. Syddall, A. Syvänen, Toshiko Tanaka, B. Thorand, J. Tichet, A. Tönjes, T. Tuomi, A. Uitterlinden, K. W. van Dijk, M. van Hoek, Dhiraj Varma, S. Visvikis-Siest, V. Vitart, N. Vogelzangs, G. Waeber, Peter J Wagner, A. Walley, G. Walters, K. Ward, H. Watkins, M. Weedon, S. Wild, G. Willemsen, J. Witteman, J. Yarnell, E. Zeggini, D. Zélénika, B. Zethelius, G. Zhai, J. Zhao, M. Zillikens, I. Borecki, R. Loos, P. Meneton, P. Magnusson, D. Nathan, G. Williams, A. Hattersley, K. Silander, V. Salomaa, G. Smith, S. Bornstein, P. Schwarz, J. Spranger, F. Karpe, A. Shuldiner, C. Cooper, G. Dedoussis, M. Serrano-Ríos, A. Morris, L. Lind, L. Palmer, F. Hu, P. Franks, S. Ebrahim, M. Marmot, W. Kao, J. Pankow, M. Sampson, J. Kuusisto, M. Laakso, T. Hansen, O. Pedersen, P. Pramstaller, H. Wichmann, T. Illig, I. Rudan, A. Wright, M. Stumvoll, H. Campbell, James F. Wilson, A. Hamsten, R. Bergman, T. Buchanan, F. Collins, K. Mohlke, J. Tuomilehto, T. Valle, D. Altshuler, J. Rotter, D. Siscovick, B. Penninx, D. Boomsma, P. Deloukas, T. Spector, T. Frayling, L. Ferrucci, A. Kong, U. Thorsteinsdóttir, K. Stefánsson, C. V. van Duijn, Y. Aulchenko, A. Cao, A. Scuteri, D. Schlessinger, M. Uda, A. Ruokonen, M. Jarvelin, D. Waterworth, P. Vollenweider, L. Peltonen, V. Mooser, G. Abecasis, N. Wareham, R. Sladek, P. Froguel, R. Watanabe, J. Meigs, L. Groop, M. Boehnke, M. McCarthy, J. Florez, I. Barroso   +303 more
semanticscholar   +1 more source

Crosstalk between Photoreceptor and Sugar Signaling Modulates Floral Signal Transduction

Frontiers in Physiology, 2017
Over the past decade, integrated genetic, cellular, proteomic and genomic approaches have begun to unravel the surprisingly crosstalk between photoreceptors and sugar signaling in regulation of floral signal transduction.
Ianis G. Matsoukas
doaj   +1 more source

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]

, 2019
Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin, Brans, Toon, Declercq, Wim, Fraire, Juan, Raemdonck, Koen, Raes, Laurens, Roelandt, Ria, Saelens, Xavier, Stremersch, Stephan, Van Hoecke, Lien, Vandenabeele, Peter   +10 more
core   +2 more sources

GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]

, 2013
Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes, Csilla Nemes, Eszter Varga, Jalving M., Melinda K. Pirity, Nuttha Klincumhom, Zsuzsanna Polgar   +6 more
core   +1 more source

Interplay Between Sugar and Hormone Signalling Pathways Modulate Floral Signal Transduction

Frontiers in Genetics, 2014
The juvenile-to-adult and vegetative-to-reproductive phase transitions are major determinants of plant reproductive success and adaptation to the local environment.
Ianis G. Matsoukas, Ianis G. Matsoukas
doaj   +1 more source