Results 51 to 60 of about 3,488,111 (320)

Protein transduction: A novel tool for tissue regeneration [PDF]

, 2002
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Derer W., Han K., Ho A., Park J., Theodore L.   +4 more
core   +1 more source

Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction

Scientific Reports, 2017
The use of viral vectors for inner ear gene therapy is receiving increased attention for treatment of genetic hearing disorders. Most animal studies to date have injected viral suspensions into neonatal ears, via the round window membrane.
Jun Suzuki, Jun Suzuki, Jun Suzuki, Ken Hashimoto, Ken Hashimoto, Ken Hashimoto, Ru Xiao, L. Vandenberghe, M. Liberman, M. Liberman   +9 more
semanticscholar   +1 more source

Productive infection and transduction by bacteriophage P1 in the species Salmonella bongori

Electronic Journal of Biotechnology, 2019
Background: Horizontal gene transfer (HGT) is the most important mechanism in the evolution of new genetic capabilities in bacteria, including specific degradative pathways, virulence factors, and resistance to antibiotics.
Natalia A. Riquelme, Marcela F. Leon, Javier A. Santander, James P. Robeson   +3 more
doaj   +1 more source

Directed evolution reveals the mechanism of HitRS signaling transduction in Bacillus anthracis.

PLoS Pathogens, 2020
Two component systems (TCSs) are a primary mechanism of signal sensing and response in bacteria. Systematic characterization of an entire TCS could provide a mechanistic understanding of these important signal transduction systems.
Hualiang Pi, Michelle L Chu, Samuel J Ivan, Casey J Latario, Allen M Toth, Sophia M Carlin, Gideon H Hillebrand, Hannah K Lin, Jared D Reppart, Devin L Stauff, Eric P Skaar   +10 more
doaj   +1 more source

Prostaglandin E2 as transduction enhancer affects competitive engraftment of human hematopoietic stem and progenitor cells

Molecular Therapy: Methods & Clinical Development, 2023
Ex vivo gene therapy (GT) is a promising treatment for inherited genetic diseases. An ideal transduction protocol should determine high gene marking in long-term self-renewing hematopoietic stem cells (HSCs), preserving their repopulation potential ...
Valentina Poletti, Annita Montepeloso, Danilo Pellin, Alessandra Biffi   +3 more
doaj   +1 more source

Mechanism of Fruit Ripening - Chapter 16 [PDF]

, 2010
The fruit ripening process has been viewed over the last decades as being successively of physiological, biochemical, and molecular nature. Fruit ripening is accompanied by a number of biochemical events, including changes in color, sugar, acidity ...
Bouzayen, Mondher, Latché, Alain, Nath, Pavendra, Pech, Jean-Claude   +3 more
core   +1 more source

Transcription Factors and Their Roles in Signal Transduction in Plants under Abiotic Stresses

Current Genomics, 2017
: In agricultural production, abiotic stresses are known as the main disturbance leading to negative impacts on crop performance. Research on elucidating plant defense mechanisms against the stresses at molecular level has been addressed for years in ...
Xuan Lan Thi Hoang, Duong Ngoc Thao Nhi, N. Thu, N. Thao, L. Tran   +4 more
semanticscholar   +1 more source

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. [PDF]

, 2018
Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD).
A Berson, A Jovičić, AA Dominguez, Aaron D. Gitler, AC Elden, AD Gitler, AD Gitler, AD Gitler, AE Renton, AM Jablonski, Amy Li, Ana Jovičić, AS Ng, BD Freibaum, C Sidrauski, C Sidrauski, C. Kimberly Tsui, D Ron, David W. Morgens, DW Morgens, DW Morgens, E Yeger-Lotem, EM Lynes, EY Son, FB Gao, Gregor Bieri, H Koike-Yusa, HJ Kim, HJ Kim, I Kwon, IR Mackenzie, IR Mackenzie, J Couthouis, J Joung, James Ousey, JC Christianson, JG Wideman, JP Taylor, Julien Couthouis, Justin K. Ichida, K Kanekura, K Mori, K Zhang, KH Lee, KM Green, KY Shi, L Ellgaard, L Huang, LA Becker, LA Gilbert, LA Gilbert, M Armakola, M DeJesus-Hernandez, M Neumann, M Prudencio, MA Horlbeck, Marc Tessier-Lavigne, MC Jonikas, MH Schludi, MI Love, Michael C. Bassik, Michael S. Haney, NF Liachko, Nicholas J. Kramer, Nicholas T. Hertz, O Shalem, OM Peters, PE Ash, Q Zhou, R Dafinca, R Lopez-Gonzalez, R Seijffers, RJ Platt, RM Deans, Rosanna Ma, S Boeynaems, S Boeynaems, S Ju, S Konermann, S Mizielinska, S Treusch, SC Ling, SJ Zhang, T Wang, T Westergard, T Zu, TF Gendron, W Cheng, X Wen, Y Lin, Y Zhou, Yingxiao Shi, YJ Zhang, YS Davidson, Z Shevtsova, Z Sun   +95 more
core   +1 more source

Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis

Communications Biology
The limitations of TB treatment are the long duration and immune-dampening effects of anti-tuberculosis therapy. The Cell wall plays a crucial role in survival and virulence; hence, enzymes involved in its biosynthesis are good therapeutic targets. Here,
Meetu Agarwal, Ashima Bhaskar, Biplab Singha, Suparba Mukhopadhyay, Isha Pahuja, Archna Singh, Shivam Chaturvedi, Nisheeth Agarwal, Ved Prakash Dwivedi, Vinay Kumar Nandicoori   +9 more
doaj   +1 more source

A quantitative comparison of sRNA-based and protein-based gene regulation [PDF]

, 2008
Small, non-coding RNAs (sRNAs) play important roles as genetic regulators in prokaryotes. sRNAs act post-transcriptionally via complementary pairing with target mRNAs to regulate protein expression.
Berg HC, Ned S Wingreen, Pankaj Mehta, Ptashne M, Sidhartha Goyal, van Kampen NG   +5 more
core   +3 more sources