Results 41 to 50 of about 7,843,232 (348)

Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.

Genes & Development, 1994
The CCAAT/enhancer-binding protein alpha (C/EBP alpha) has been implicated in the regulation of adipoblast differentiation. In this study we investigate the potential of C/EBP alpha to promote the adipogenic program in a variety of fibroblastic cells ...
S. Freytag, D. Paielli, J. D. Gilbert
semanticscholar   +1 more source

Comparative Cardiac Gene Delivery of Adeno‐Associated Virus Serotypes 1–9 reveals that AAV6 Mediates the Most Efficient Transduction in Mouse Heart

Clinical and Translational Science, 2010
Cardiac gene transfer is an attractive tool for developing novel heart disease treatments. Adeno‐associated viral (AAV) vectors are widely used to mediate transgene expression in animal models and are being evaluated for human gene therapy.
C. Zincarelli, S. Soltys, G. Rengo, W. Koch, J. Rabinowitz   +4 more
semanticscholar   +1 more source

Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]

, 2018
Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core   +2 more sources

Optimization of lentiviral delivery of barcoded anti-CD20 chimeric antigen receptors into rhesus macaque and human natural killer cells

Molecular Therapy: Methods & Clinical Development
Natural killer (NK) cells are pivotal in immunosurveillance and hold great potential for immunotherapy due to their ability to target malignant cells. Their low risk of causing graft-versus-host disease (GvHD) post-allogenic transplantation underscores ...
Taha B. Hayal, Aman A. Mulla, David S.J. Allan, Brynn B. Duncan, Saanika Joshi, So Gun Hong, Rafet Basar, Katayoun Rezvani, Richard W. Childs, Chuanfeng Wu, Cynthia E. Dunbar   +10 more
doaj   +1 more source

Molecular insights from the crab Neohelice memory model

Frontiers in Molecular Neuroscience, 2023
Memory acquisition, formation and maintenance depend on synaptic post-translational machinery and regulation of gene expression triggered by several transduction pathways.
Arturo Romano, Arturo Romano, Ramiro Freudenthal, Ramiro Freudenthal, Mariana Feld   +4 more
doaj   +1 more source

Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones

Neurosignals, 2010
Changes in the expression of the neuropeptide substance P (SP) in different populations of sensory neurones are associated with the progression of chronic inflammatory disease.
Lynne Shanley, Scott Davidson, Marissa Lear, Anil Kumar Thotakura, Iain Joseph McEwan, Ruth A. Ross, Alasdair MacKenzie   +6 more
doaj   +1 more source

PEG-mediated transduction of rAAV as a platform for spatially confined and efficient gene delivery

Biomaterials Research, 2022
Background Recombinant adeno-associated viruses (rAAV) are commonly used vectors for gene delivery in both basic neuroscience and clinical applications due to their nonpathogenic, minimally immunogenic, and sustained expression properties.
Liang Zou, Jinfen Wang, Ying Fang, Huihui Tian   +3 more
doaj   +1 more source

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [PDF]

, 2007
Sonic hedgehog (Shh) acts as a morphogen to mediate the specification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network.
Davidson, Eric H., Giles, Shane, Ji, Hongkai, Longabaugh, William J. R., McCuine, Scott, McMahon, Andrew P., Tenzen, Toyoaki, Vokes, Steven A., Wong, Wing H., Zhong, Sheng   +9 more
core   +2 more sources

Octominin Inhibits LPS-Induced Chemokine and Pro-inflammatory Cytokine Secretion from RAW 264.7 Macrophages via Blocking TLRs/NF-κB Signal Transduction

Biomolecules, 2020
Inflammation is a well-organized innate immune response that plays an important role during the pathogen attacks and mechanical injuries. The Toll-like receptors (TLR)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a major ...
K. K. Asanka Sanjeewa, D. P. Nagahawatta, Hye-Won Yang, Jae Young Oh, Thilina U. Jayawardena, You-Jin Jeon, Mahanama De Zoysa, Ilson Whang, Bomi Ryu   +8 more
doaj   +1 more source

Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling

Scientific Reports, 2021
Netrin-1 is a secreted protein that is well known for its involvement in axonal guidance during embryonic development and as an enhancer of cancer cell metastasis.
Ahmad Abdullah, Carl Herdenberg, Håkan Hedman   +2 more
doaj   +1 more source