Results 41 to 50 of about 145,799 (355)

Molecular insights from the crab Neohelice memory model

Frontiers in Molecular Neuroscience, 2023
Memory acquisition, formation and maintenance depend on synaptic post-translational machinery and regulation of gene expression triggered by several transduction pathways.
Arturo Romano, Arturo Romano, Ramiro Freudenthal, Ramiro Freudenthal, Mariana Feld   +4 more
doaj   +1 more source

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization. [PDF]

, 2014
Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells ...
Benner, Christopher, Glass, Christopher K, Heinz, Sven, Kaikkonen, Minna U, Kansanen, Emilia, Kivelä, Annukka M, Laitalainen, Jarkko, Niskanen, Henri, Romanoski, Casey E, Ylä-Herttuala, Seppo   +9 more
core   +1 more source

Transduction of Immortalized Human Hepatocytes with p21 to Enhance Differentiated Phenotypes [PDF]

Cell Transplantation, 2002
We previously constructed an immortal human hepatocyte line NKNT-3 with a simian virus 40 T antigen (SV40T) to develop cell-based biological therapies. p21 is a molecule that regulates the transition from the G1 phase to the S phase of the cell cycle.
Takemi Kunieda, Naoya Kobayashi M.D., Ph.D., Masakiyo Sakaguchi, Teru Okitsu, Toshinori Totsugawa, Takamasa Watanabe, Toshihisa Matsumura, Masanobu Maruyama, Hirofumi Noguchi, Michihiko Takesue, Norikuni Shibata, Kenji Ohmoto, Toshiyoshi Fujiwara, Shinichiro Yamamoto, Noriaki Tanaka   +14 more
openaire   +3 more sources

Optimization of lentiviral delivery of barcoded anti-CD20 chimeric antigen receptors into rhesus macaque and human natural killer cells

Molecular Therapy: Methods & Clinical Development
Natural killer (NK) cells are pivotal in immunosurveillance and hold great potential for immunotherapy due to their ability to target malignant cells. Their low risk of causing graft-versus-host disease (GvHD) post-allogenic transplantation underscores ...
Taha B. Hayal, Aman A. Mulla, David S.J. Allan, Brynn B. Duncan, Saanika Joshi, So Gun Hong, Rafet Basar, Katayoun Rezvani, Richard W. Childs, Chuanfeng Wu, Cynthia E. Dunbar   +10 more
doaj   +1 more source

Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones

Neurosignals, 2010
Changes in the expression of the neuropeptide substance P (SP) in different populations of sensory neurones are associated with the progression of chronic inflammatory disease.
Lynne Shanley, Scott Davidson, Marissa Lear, Anil Kumar Thotakura, Iain Joseph McEwan, Ruth A. Ross, Alasdair MacKenzie   +6 more
doaj   +1 more source

PEG-mediated transduction of rAAV as a platform for spatially confined and efficient gene delivery

Biomaterials Research, 2022
Background Recombinant adeno-associated viruses (rAAV) are commonly used vectors for gene delivery in both basic neuroscience and clinical applications due to their nonpathogenic, minimally immunogenic, and sustained expression properties.
Liang Zou, Jinfen Wang, Ying Fang, Huihui Tian   +3 more
doaj   +1 more source

Enhanced transduction of mouse salivary glands with AAV5-based vectors [PDF]

Gene Therapy, 2005
We previously demonstrated that recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) can direct transgene expression in salivary gland cells in vitro and in vivo. However, it is not known how other rAAV serotypes perform when infused into salivary glands.
H, Katano, M R, Kok, A P, Cotrim, S, Yamano, M, Schmidt, S, Afione, B J, Baum, J A, Chiorini   +7 more
openaire   +2 more sources

Octominin Inhibits LPS-Induced Chemokine and Pro-inflammatory Cytokine Secretion from RAW 264.7 Macrophages via Blocking TLRs/NF-κB Signal Transduction

Biomolecules, 2020
Inflammation is a well-organized innate immune response that plays an important role during the pathogen attacks and mechanical injuries. The Toll-like receptors (TLR)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a major ...
K. K. Asanka Sanjeewa, D. P. Nagahawatta, Hye-Won Yang, Jae Young Oh, Thilina U. Jayawardena, You-Jin Jeon, Mahanama De Zoysa, Ilson Whang, Bomi Ryu   +8 more
doaj   +1 more source

Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling

Scientific Reports, 2021
Netrin-1 is a secreted protein that is well known for its involvement in axonal guidance during embryonic development and as an enhancer of cancer cell metastasis.
Ahmad Abdullah, Carl Herdenberg, Håkan Hedman   +2 more
doaj   +1 more source

JSRV Intragenic Enhancer Element Increases Expression from a Heterologous Promoter and Promotes High Level AAV-Mediated Transgene Expression in the Lung and Liver of Mice

Viruses, 2020
Jaagsiekte sheep retrovirus (JSRV) induces tumors in the distal airways of sheep and goats. A putative intragenic enhancer, termed JE, localized to the 3′ end of the JSRV env gene, has been previously described.
Darrick L. Yu, Natalie Chow, Sarah K. Wootton   +2 more
doaj   +1 more source