Results 71 to 80 of about 332 (146)

Comparative In-Vitro, Ex-Vivo, and In-Vivo Evaluation Of Nanocarrier-Based Transdermal Voriconazole Delivery

open access: yesBulletin of Pharmaceutical Sciences. Assiut University
Voriconazole (VRC), a first-line antifungal agent used for the treatment of systemic fungal infections, exhibits moderate aqueous solubility, nonlinear pharmacokinetics, extensive hepatic metabolism following oral administration, and toxicity concerns ...
Mai Rasheedy   +3 more
doaj   +1 more source

Design and Characterization of Transethosomes loaded with Rivastigmine for Enhanced Transdermal Delivery

open access: yesJournal of Research in Pharmacy
This research aimed to create and optimize a transethosomal patch containing Rivastigmine Hydrogen Tartarate, a cholinesterase inhibitor, for the symptomatic management of Alzheimer's disease that would reduce drug loading and patch size. Transethosomes are elastic vesicles made up of phospholipids, ethanol, and edge activator.
Lobo, Cynthia Lizzie, Priya, Sneh
openaire   +2 more sources

Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation

open access: yesDrug Design, Development and Therapy, 2018
Ibrahim M Abdulbaqi, Yusrida Darwis, Reem Abou Assi, Nurzalina Abdul Karim Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia Introduction: Colchicine is used for the treatment of gout, pseudo-gout, familial ...
Abdulbaqi IM   +3 more
doaj  

Development and evaluation of eugenol-loaded transethosomal gel as a potential topical therapy for onychomycosis: In Vitro dose determination, drug release profiling, and antifungal activity against Trichophyton rubrum

open access: yesNext Materials
Introduction: Onychomycosis is a serious nail condition primarily caused by Trichophyton rubrum. Eugenol, a natural phenolic compound with antifungal properties, serves as a safer treatment approach for onychomycosis, showing low aqueous solubility and ...
Ishu Garg   +6 more
doaj   +1 more source

TRANSETHOSOMES: A PROMISING VESICULAR SYSTEM FOR OSTEOARTHRITIS DRUG DELIVERY

open access: yes
Osteoarthritis (OA) is a long-term degenerative joint condition that progressively impairs movement and reduces quality of life, especially among older and obese individuals. Existing treatments, such as oral nonsteroidal anti-inflammatory drugs, mainly provide symptomatic relief but are often associated with systemic side effects and insufficient drug
openaire   +3 more sources

Formulation and Evaluation of Allopurinol Loaded Transethosomal Gel

open access: yes
The main aim of this research is formulate allopurinol loaded Transethosomal gel in which Transethosomes of allopurinol were composed of different concentration of soya lecithin, Cholesterol, tween-80 and solvent by using the cold method. Transethosomes were characterized of entrapment efficient, SEM (scanning electron microscopy), FTIR (Fourier ...
openaire   +2 more sources

DIFLUNISAL TRANSETHOSOMAL GEL FOR TOPICAL DRUG DELIVERY: FORMULATION AND CHARACTERIZATION

open access: yesMedical Sains : Jurnal Ilmiah Kefarmasian
Transethosomes are modern vesicular systems designed to enhance the transdermal delivery of various types of drugs, including lipophilic and hydrophilic drugs. This system features a flexible and easily deformable membrane resulting from the combination of phospholipids, ethanol, and surfactants as edge activators.
Indah Aprianti   +2 more
openaire   +1 more source

Transethosomes: Novel Transdermal Drug Delivery Technology

open access: yes
The transdermal route is one of the effective routes for delivering drugs. It also overcomes many limitations associated with oral delivery. One of the limitations of this route is the drug’s poor skin permeability—stratum corneum, the skin’s outermost layer that also acts as a barrier for the drug to penetrate.
openaire   +2 more sources

Transethosomes as Vesicular Drug Delivery : a Modified Form of Ethosomes and Transfersomes

open access: yesRanah Research : Journal of Multidisciplinary Research and Development
Liposomal vesicle formulations can be classified into two categories, namely rigid hard vesicles such as liposomes and elastic vesicles such as transferosome. One of the shortcomings of conventional liposomes is their permeation strength in the stratum corneum, so that in later generations liposomes are designed to be able to better overcome these ...
Meiti Rosmiati   +2 more
openaire   +1 more source

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