Results 151 to 160 of about 280,113 (289)

Deconvolution of cargo delivery and immunogenicity following intranasal delivery of mRNA lipid nanoparticle vaccines

Molecular Therapy: Nucleic Acids
Intranasal vaccination aims to elicit mucosal immunity in the respiratory tract to better protect against respiratory infections (e.g., SARS-CoV-2 and influenza). Most vaccines, including recent COVID-19 mRNA lipid nanoparticles (LNPs), are optimized for
Mai N. Vu, Devaki Pilapitiya, Andrew Kelly, Marios Koutsakos, Stephen J. Kent, Jennifer A. Juno, Hyon-Xhi Tan, Adam K. Wheatley   +7 more
doaj   +1 more source

Effect of the array of amines on the transfection efficiency of cationic peptidomimetic lipid molecules into neural cells. [PDF]

RSC Adv, 2022
Yu X, Xiao H, Muqier M, Han S, Baigude H.   +4 more
europepmc   +1 more source

Macrophage Membrane‐Camouflaged Nanozyme Microneedles Restore Immunovascular Homeostasis Through SPP1‐ApoE Signaling in Diabetic Wounds

Advanced Healthcare Materials, EarlyView.
Macrophage membrane‐coated Cu/Zn‐MOF nanozyme microneedles (MNs) reprogram the diabetic wound microenvironment through localized, minimally invasive delivery. By suppressing M1‐like macrophage activation while promoting extracellular matrix deposition and angiogenesis, this biomimetic platform accelerates diabetic wound repair.
Qipeng Wu, Yuan Xiong, Li Lu, Han Wang, Hui Hu, Mohammad‐Ali Shahbazi, Guohui Liu, Bobin Mi   +7 more
wiley   +1 more source

Maximizing transfection efficiency of vertically aligned silicon nanowire arrays [PDF]

, 2015
Maximizing transfection efficiency of vertically aligned silicon nanowire ...
T Kraus (13390797), NH Voelcker (14118324), H Alhmoud (13390800), D Brodoceanu (13390788), FJ Harding (15838886), L Isa (13390974), Roey Elnathan (13090821), B Delalat (13390794), A Nelson (7714604), K Buehler (13391265)   +9 more
core  

Oxygen nanocarrier broke the hypoxia trap of solid tumors and rescued transfection efficiency for gene therapy. [PDF]

J Nanobiotechnology, 2021
Qin B, Jiang M, Li X, Shi Y, Zhang J, Luo Z, Luo L, Lu Y, Liu X, Wang S, Du Y, Qiu Y, Lou Y, You J.   +13 more
europepmc   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Correlation between Biophysical Properties of Niosomes Elaborated with Chloroquine and Different Tensioactives and Their Transfection Efficiency. [PDF]

Pharmaceutics, 2021
Sainz-Ramos M, Villate-Beitia I, Gallego I, Al Qtaish N, Menéndez M, Lagartera L, Grijalvo S, Eritja R, Puras G, Pedraz JL.   +9 more
europepmc   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Synthesis and Characterization of Oleic Acid-Coated Calcium Phosphate Nanoparticles for Gene Delivery Applications

Trends in Pharmacy
Background: Efficient gene delivery remains a major challenge in gene therapy, necessitating the development of biocompatible and effective carrier systems.
Meryem Akkurt Yıldırım
doaj  

Preparation and Optimization of MiR-375 Nano-Vector Using Two Novel Chitosan-Coated Nano-Structured Lipid Carriers as Gene Therapy for Hepatocellular Carcinoma

Pharmaceutics
Currently, there is still a lack of effective carriers with minimal side effects to deliver therapeutic miRNA. Thus, it is crucial to optimize novel drug delivery systems. MiR-375 has proven superior therapeutic potency in Hepatocellular carcinoma (HCC).
Bangly Soliman, Ming Ming Wen, Eman Kandil, Basma El-Agamy, Amira M. Gamal-Eldeen, Mahmoud ElHefnawi   +5 more
doaj   +1 more source