A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells. [PDF]
Pharmaceutics, 2022 de la Torre C +7 more
europepmc +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Study on the Transfection Efficiency of the New Cationic Polymer Transfection Reagent: Sofast [PDF]
, 2004 采用DNA延滞实验研究新一代阳离子聚合物梭华 Sofast转染试剂与DNA的结合能力,以不同报告基因(绿色荧光蛋白基因、β 半乳糖苷酶基因和荧光素酶基因),分析比较梭华 Sofast与阳离子脂质体Lipofectamine2000和阳离子聚合物JetPEI、Superfect转染HEK293细胞转染效率和细胞毒性,研究梭华 Sofast转染试剂转染效率.实验结果表明梭华 Sofast与DNA有很强的结合能力;以绿色荧光蛋白基因为报告基因,梭华 Sofast转染率最高,约60%左右 ...
杨天赐, 黄革玲, 陈明桥
core
Nucleofection of Adipose Mesenchymal Stem/Stromal Cells: Improved Transfection Efficiency for GMP Grade Applications. [PDF]
Cells, 2021 Agostini F +7 more
europepmc +1 more source
Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
Advanced Materials, EarlyView.Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi +4 more
wiley +1 more source
The Influence of Circadian Rhythm on Cancer Cells Targeting and Transfection Efficiency of a Polycation-Drug/Gene Delivery Vector. [PDF]
Polymers (Basel), 2022 Albuquerque T +3 more
europepmc +1 more source
Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Advanced Materials, EarlyView.Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley +1 more source
Gemini Lipopeptide Bearing an Ultrashort Peptide for Enhanced Transfection Efficiency and Cancer-Cell-Specific Cytotoxicity. [PDF]
ACS Omega, 2021 Ravula V, Lo YL, Wang LF, Patri SV.
europepmc +1 more source
Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy
Advanced Materials, EarlyView.Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla +15 more
wiley +1 more source
Rapid Assessment of CRISPR Transfection Efficiency and Enrichment of CRISPR Induced Mutations Using a Dual-Fluorescent Stable Reporter System. [PDF]
Front Genome Ed, 2022 Shalaby KE +4 more
europepmc +1 more source