Results 61 to 70 of about 760 (163)

Soft Nanocarriers as Antimicrobial Co‐Delivery Systems to Combat Resistant Infections

Advanced Healthcare Materials, Volume 14, Issue 21, August 19, 2025.
Soft nanocarrier‐based co‐delivery systems present a versatile and promising platform for combating antimicrobial resistance (AMR) by enabling spatiotemporally controlled, pathogen‐specific drug release. Their tunable physicochemical properties allow for the co‐encapsulation of synergistic antimicrobial agents, optimization of drug ratios, and surface ...
Anamarija Nikoletic, Evangelos Natsaridis, Timon Flathmann, Daiane P. C. Quadros, Nubia Gogniat, Oya Tagit   +5 more
wiley   +1 more source

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, Volume 310, Issue 6, June 2025.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

MedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu, Shiyuan Huang, Li Peng, Li Yang, Guosong Zhang, Tao Liu, Fang Yan, Xi Peng   +7 more
wiley   +1 more source

Formulation Optimization, Physicochemical Characterization, and Biocompatibility Assessment of Curcumin‐Loaded Aquasomes

Nano Select, Volume 6, Issue 6, June 2025.
This study explores a novel approach to enhance the bioavailability and functionality of curcumin by loading it onto HAP cores coated with various disaccharides. To improve the delivery and stability of the HAP cores, they were coated with different disaccharides; lactose, maltose, sucrose, and trehalose.
Fernando Bwalya, Murat Erdem, Mustafa Sinan Kaynak   +2 more
wiley   +1 more source

Role of Surface Active Agents in Transferosome for Systemic Drug Delivery

Al-Mustansiriyah Journal of Pharmaceutical Sciences
The recent utilization of transferosomes (a type of vesicular drug-carrier system) has shown promising results in enhancing the transport of drugs through the skin when administered topically.
Mohsin Hussein Abdulameer, Nidhal Khazaal Maraie, Zainab H. Mahdi   +2 more
doaj   +1 more source

A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines

Advanced NanoBiomed Research, Volume 5, Issue 3, March 2025.
Nanomaterial‐integrated microneedles revolutionize transdermal delivery, enabling targeted and controlled administration of therapeutics and vaccines. This review explores advancements in design, manufacturing, and applications, emphasizing enhanced drug stability, bioavailability, and patient adherence. Key preclinical and clinical findings as well as
Bwalya Angel Witika, Aaron Hutton, Pedzisai A. Makoni, Ryan F. Donnelly   +3 more
wiley   +1 more source

Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers

Drug Delivery, 2017
Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable oral absorption.
Mohammed H. Elkomy, Shahira F. El Menshawe, Heba A. Abou-Taleb, Marwa H. Elkarmalawy   +3 more
doaj   +1 more source

Overcoming the Blood–Brain Barrier: Multifunctional Nanomaterial‐Based Strategies for Targeted Drug Delivery in Neurological Disorders

Small Science, Volume 4, Issue 12, December 2024.
This review explores the diverse range of nanomaterials, including polymer, lipid, gold, magnetic, and carbon‐based nanostructures, capable of effectively passing the blood–brain barrier (BBB). Moreover, the structure and function of the BBB in both healthy and diseased states are discussed and the potential of nanotechnology in bypassing the BBB to ...
Callan D. McLoughlin, Sarah Nevins, Joshua B. Stein, Mehrdad Khakbiz, Ki‐Bum Lee   +4 more
wiley   +1 more source

OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage

Medicinal Research Reviews, Volume 44, Issue 6, Page 2825-2848, November 2024.
Abstract Oxidative DNA damage‐related diseases, such as incurable inflammation, malignant tumors, and age‐related disorders, present significant challenges in modern medicine due to their complex molecular mechanisms and limitations in identifying effective treatment targets.
Yunxiao Zhong, Xinya Zhang, Ruibing Feng, Yu Fan, Zhang Zhang, Qing‐Wen Zhang, Jian‐Bo Wan, Yitao Wang, Hua Yu, Guodong Li   +9 more
wiley   +1 more source

Development of transfersomal buccal patches of galantamine for enhanced bioavailability in Alzheimer’s disease therapy

Journal of Applied Pharmaceutical Research
Background: Galantamine, an acetylcholinesterase inhibitor used in Alzheimer’s disease, exhibits low and variable bioavailability due to gastrointestinal metabolism and first-pass hepatic elimination. Buccal drug delivery offers a non-invasive route that
Pavuluri Chandrasekhar, Rajaganapathy Kaliyaperumal   +1 more
doaj   +1 more source