Results 71 to 80 of about 1,164,783 (293)
Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival. [PDF]
PLoS Pathogens, 2011 During infection Neisseria meningitidis (Nm) encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal survival.
Hebert Echenique-Rivera +7 more
doaj +1 more source
MXene Wrapped Magnetic Mesocrystals for Durable Redox Catalytic Cancer Therapy and Responsive MRI
Advanced Functional Materials, EarlyView.Conformal wrapping of ultrathin Ti3C2Tx MXene nanosheets on Fe3O4 mesocrystals creates topology‐stabilized Schottky junctions that direct photoinduced electron transfer under NIR irradiation. The unique architecture sustains Fenton catalysis, promotes continuous hydroxyl radical production, and provides photo‐responsive MRI contrast.
Min Jun Ko +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham +11 more
wiley +1 more source
The NewroBus platform: engineered humanized anti-TfR1 nanobodies for efficient brain delivery
Cell Communication and SignalingBackground Delivery of biologic therapeutics to the central nervous system (CNS) is hindered by the blood–brain barrier (BBB), which restricts large molecule passage.
Tao Yin +6 more
doaj +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Pseudokinase NRP1 facilitates endocytosis of transferrin in the African trypanosome
Scientific Reports, 2022 Trypanosoma brucei causes human African trypanosomiasis (HAT) and nagana in cattle. During infection of a vertebrate, endocytosis of host transferrin (Tf) is important for viability of the parasite.
Gaurav Kumar +2 more
doaj +1 more source
Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species [PDF]
BMC Microbiology, 2008 Transferrin binding protein B (tbpB), an outer membrane lipoprotein, is required for the acquisition of iron from human transferrin. Two tbpB families have been documented in Neisseria meningitidis: an isotype I tbpB gene of 1.8 kb and an isotype II tbpB gene of 2.1 kb, the former expressed by meningococci in the disease-associated ST-11 clonal complex
Harrison, O, Maiden, M, Rokbi, B
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez +6 more
wiley +1 more source
The 126 kDa iron-regulated protein ofListeria monocytogenesis not a transferrin binding protein [PDF]
FEMS Microbiology Letters, 1994 It has been reported that a 126 kDa protein of Listeria monocytogenes binds human transferrin. It is evident from results presented here that this is not so and that the observation of others resulted from interaction of this 126 kDa protein with streptavidin.
R, Bhatt +3 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source