Results 1 to 10 of about 2,476,207 (253)

Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles

Pharmaceutics, 2022
The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for the delivery of biologics across the BECs, as they can encapsulate numerous molecules of ...
Maj Schneider Thomsen, Kasper Bendix Johnsen, Krzysztof Kucharz, Martin Lauritzen, Torben Moos   +4 more
doaj   +2 more sources

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant [PDF]

BMC Cell Biology, 2010
Background Optineurin is a multifunctional protein involved in several functions such as vesicular trafficking from the Golgi to the plasma membrane, NF-κB regulation, signal transduction and gene expression.
Rangaraj Nandini, Radha Vegesna, Jain Nishant, Chalasani Madhavi L, Nagabhushana Ananthamurthy, Balasubramanian Dorairajan, Swarup Ghanshyam   +6 more
doaj   +2 more sources

Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool

Tumor Biology, 2017
Labile iron pool is a cellular source of ions available for Fenton reactions resulting in oxidative stress. Living organisms avoid an excess of free irons by a tight control of iron homeostasis.
Wassana Jamnongkan, Raynoo Thanan, Anchalee Techasen, Nisana Namwat, Watcharin Loilome, Piyapharom Intarawichian, Attapol Titapun, Puangrat Yongvanit   +7 more
doaj   +2 more sources

Modulation of transferrin receptor by HIV-2 [PDF]

Virology Journal
Background Human immunodeficiency viruses (HIV-1 and HIV-2), are the causative agents of the acquired immunodeficiency syndrome (AIDS), that share substantial genomic and structural similarities, yet differ in replication dynamics and disease progression.
Aya Shamal Al-Muffti, Irene Wanjiru Kiarie, József Tőzsér, Mohamed Mahdi   +3 more
doaj   +2 more sources

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica, 2015
Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe, Patrick Mayeux, Frédérique Verdier, Clara Camaschella, Laura Silvestri   +9 more
doaj   +2 more sources

Transferrin Receptor Is a Specific Ferroptosis Marker

Cell Reports, 2020
Summary: Ferroptosis is a type of regulated cell death driven by the iron-dependent accumulation of oxidized polyunsaturated fatty acid-containing phospholipids.
Huizhong Feng, Kenji Schorpp, Jenny Jin, Carrie E. Yozwiak, Benjamin G. Hoffstrom, Aubrianna M. Decker, Presha Rajbhandari, Michael E. Stokes, Hannah G. Bender, Joleen M. Csuka, Pavan S. Upadhyayula, Peter Canoll, Koji Uchida, Rajesh K. Soni, Kamyar Hadian, Brent R. Stockwell   +15 more
doaj   +2 more sources

Transferrin receptors

Experimental and Molecular Medicine
The transferrin receptor (TfR) is one of the key proteins involved in cellular iron uptake. TfR-mediated endocytosis of transferrin-bound iron is the major pathway for iron acquisition by most cells in the body.
Qian Guo, Christopher Qian, Xinyu Wang, Zhong-Ming Qian   +3 more
doaj   +2 more sources

Cryo-EM structure of the human ferritin–transferrin receptor 1 complex

Nature Communications, 2019
The human transferrin receptor 1 (CD71) is a transmembrane protein responsible for iron uptake. Here the authors present the 3.9 Å resolution cryo-EM structure of the CD71 ectodomain-human ferritin (H-Ft) complex and find that H-Ft binds a CD71 region ...
Linda Celeste Montemiglio, Claudia Testi, Pierpaolo Ceci, Elisabetta Falvo, Martina Pitea, Carmelinda Savino, Alessandro Arcovito, Giovanna Peruzzi, Paola Baiocco, Filippo Mancia, Alberto Boffi, Amédée des Georges, Beatrice Vallone   +12 more
doaj   +2 more sources

Residual erythropoiesis protects against myocardial hemosiderosis in transfusion-dependent thalassemia by lowering labile plasma iron via transient generation of apotransferrin [PDF]

Haematologica, 2017
Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis.
Maciej W. Garbowski, Patricia Evans, Evangelia Vlachodimitropoulou, Robert Hider, John B. Porter   +4 more
doaj   +3 more sources

Heterozygous transferrin receptor 1 deletion reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. [PDF]

Atheroscler Plus
Naito Y, Horimatsu T, Asakura M, Ishihara M.   +3 more
europepmc   +2 more sources