Results 1 to 10 of about 75,793 (264)
Modulation of transferrin receptor by HIV-2 [PDF]
Virology JournalBackground Human immunodeficiency viruses (HIV-1 and HIV-2), are the causative agents of the acquired immunodeficiency syndrome (AIDS), that share substantial genomic and structural similarities, yet differ in replication dynamics and disease progression.
Aya Shamal Al-Muffti +3 more
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Experimental and Molecular MedicineThe transferrin receptor (TfR) is one of the key proteins involved in cellular iron uptake. TfR-mediated endocytosis of transferrin-bound iron is the major pathway for iron acquisition by most cells in the body.
Qian Guo +3 more
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Pharmaceutics, 2022 This study systematically reviews and characterizes the existing literature on transferrin/transferrin receptor-mediated drug delivery. Transferrin is an iron-binding protein. It can be used as a ligand to deliver various proteins, genes, ions, and drugs
Tarnjot Kaur +4 more
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Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. [PDF]
PLoS ONE, 2018 One of the major drawbacks of many of the currently used cancer drugs are off-target effects. Targeted delivery is one method to minimize such unwanted and detrimental events.
Manoj Saxena +6 more
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Siberian Journal of Life Sciences and Agriculture, 2022 Transferrin is an essential component of cell growth and metabolic processes that require iron. An increase in the expression of transferrin receptors on lymphocytes ensures their differentiation, maturation and activation of proliferation.
Veronika V. Patrakeeva +2 more
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Heterotypic interactions between transferrin receptor and transferrin receptor 2 [PDF]
Blood, 2003 Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR). Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism.
Vogt, Todd M +4 more
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Transferrin Receptors in Erythropoiesis [PDF]
International Journal of Molecular Sciences, 2020 Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron-containing hemes.
Richard, Cyrielle, Verdier, Frédérique
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Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. [PDF]
PLoS ONE, 2012 Artemisinin and its main active metabolite dihydroartemisinin, clinically used antimalarial agents with low host toxicity, have recently shown potent anticancer activities in a variety of human cancer models.
Qian Ba +9 more
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BODY IRON STATUS INDICATORS AND INFLAMMATION INDICATORS DURING INFLAMMATORY BOWEL DISEASE THERAPY IN CHILDREN AND ADOLESCENTES [PDF]
Arquivos de Gastroenterologia, 2021 BACKGROUND: The treatment of patients with inflammatory bowel disease (IBD) consists of the induction and maintenance remission of the disease. Iron status indicators would be useful for the diagnosis of iron deficiency anemia, whereas the inflammation ...
Fernanda F CORRÊA, Vera L SDEPANIAN
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Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles
Pharmaceutics, 2022 The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for the delivery of biologics across the BECs, as they can encapsulate numerous molecules of ...
Maj Schneider Thomsen +4 more
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